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Imaging features of bone metastases from cholangiocarcinoma.

胆管癌骨转移的影像学特征。

  • 影响因子:3.08
  • DOI:10.1016/j.ejrad.2020.109118
  • 作者列表:"Thammaroj P","Chimcherd A","Chowchuen P","Panitchote A","Sumananont C","Wongsurawat N
  • 发表时间:2020-06-06
Abstract

PURPOSE:Cholangiocarcinoma (CCA) is the second most common primary malignant hepatic tumor originating from bile duct epithelia. Bone metastasis is uncommon and less documented. The aim of this study was to characterize the imaging features of bone metastasis from CCA. METHODS:A retrospective descriptive imaging characteristics in 199 patients (1465 lesions) diagnosed as CCA with bone metastasis were evaluated based on plain radiography, computed tomography (CT), magnetic resonance imaging (MRI) and Tc-99 m methylene diphosphonate bone scan. RESULTS:The common vertebral metastatic sites were lumbar spines (94 [47.2 %], 95 %CI 40.1-54.4), upper thoracic spines (89 patients [44.7 %], 95 % CI 37.7-51.9), and lower thoracic spines (80 [40.2 %], 95 % CI 33.3-47.4). On plain radiograph, most of lesions had osteolytic pattern (68 %) with pedicular destruction (45.3 %) whereas on CT had mixed osteolytic and osteosclerotic destruction (40.8 %). The common non-vertebral metastatic sites were ribs and pelvis (80 patients [40.2 %], 95 % CI 33.3-47.4 and 60 [30.2 %], 95 % CI 23.9-37). On plain radiograph, in the long bones, usually had permeative destruction (58.9 %), whereas on CT showed mixed osteolytic and osteosclerotic (34.6 %). On bone scan, increased-uptake was the common pattern, found in the vertebral and non-vertebral sites (93.6 % and 92.4 %). CONCLUSIONS:Bone metastasis from CCA usually occurred in the axial skeleton. The common patterns of destruction were osteolytic or mixed osteolytic and osteosclerotic. Periosteal reaction was scant in the appendicular long bones. On bone scan commonly had increased-uptake.

摘要

目的: 胆管癌 (CCA) 是起源于胆管上皮的第二大原发性肝脏恶性肿瘤。骨转移是罕见的,较少记录。本研究的目的是描述 CCA 骨转移的影像学特征。 方法: 回顾性分析 199 例 (1465 个病灶) 经 x线平片、计算机断层扫描 (CT) 、磁共振成像 (MRI) 诊断为 CCA 骨转移患者的影像学特征。并 Tc-99 亚甲基二膦酸盐骨扫描。 结果: 常见的椎体转移部位为腰椎 (94 [47.2%],95% CI 40.1-54.4),上胸椎 (89 例 [44.7%], 95% CI 37.7-51.9) 和下胸椎棘 (80 [40.2%],95% CI 33.3-47.4)。平片上多数病灶为溶骨型 (68%) 伴椎弓根破坏 (45.3%),CT 上表现为溶骨和骨硬化性混合破坏 (40.8%)。常见的非椎体转移部位为肋骨和骨盆 (80 例患者 [40.2%],95% CI 33.3-47.4 和 60 [30.2%],95% CI 23.9-37)。平片上,长骨通常有渗透性破坏 (58.9%),而 CT 上显示混合溶骨和骨硬化 (34.6%)。在骨扫描中,摄取增加是常见的模式,见于椎体和非椎体部位 (93.6% 和 92.4%)。 结论: CCA 骨转移多发生于中轴骨骼。常见的破坏方式为溶骨或混合溶骨和骨硬化。阑尾长骨骨膜反应很少。骨扫描通常有摄取增加。

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