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Thermal and thermal damage responses during switching bipolar radiofrequency ablation employing bipolar needles: A computational study on the effects of different electrode configuration, input voltage and ablation duration.

采用双极针的开关双极射频消融过程中的热损伤和热损伤响应: 不同电极配置、输入电压和消融持续时间影响的计算研究。

  • 影响因子:2.44
  • DOI:10.1002/cnm.3374
  • 作者列表:"Cheong JKK","Ooi EH","Ooi ET
  • 发表时间:2020-06-09
Abstract

:Recent studies have demonstrated the effectiveness of switching bipolar radiofrequency ablation (bRFA) in treating liver cancer. Nevertheless, the clinical use of the treatment remains less common than conventional monopolar RFA - likely due to the lack of understanding of how the tissues respond thermally to the switching effect. The problem is exacerbated by the numerous possible switching combinations when bRFA is performed using bipolar needles, thus making theoretical deduction and experimental studies difficult. This article addresses this issue via computational modelling by examining if significant variation in the treatment outcome exists amongst six different electrode configurations defined by the X-, C-, U-, N-, Z- and O-models. Results indicated that the tissue thermal and thermal damage responses varied depending on the electrode configuration and the operating conditions (input voltage and ablation duration). For a spherical tumour, 30 mm in diameter, complete ablation could not be attained in all configurations with 70 V input voltage and 5 minutes ablation duration. Increasing the input voltage to 90 V enlarged the coagulation zone in the X-model only. With the other configurations, extending the ablation duration to 10 minutes was found to be the better at enlarging the coagulation zone.

摘要

: 最近的研究已经证明了开关双极射频消融 (bRFA) 治疗肝癌的有效性。尽管如此,该治疗的临床使用仍然不如传统的单极 RFA 普遍 -- 可能是由于缺乏对组织如何对转换效应做出热反应的理解。当使用双极针进行 bRFA 时,许多可能的开关组合加剧了这个问题,从而使得理论推导和实验研究变得困难。本文通过计算建模来解决这个问题,通过检查 X-、 C-、 U-、 N-定义的六种不同电极配置中是否存在治疗结果的显著变化,Z 和 O 模型。结果表明,组织热和热损伤响应因电极配置和操作条件 (输入电压和消融持续时间) 而异。对于直径为 30mm 的球形肿瘤,在输入电压为 70 v 、消融时间为 5 min 的情况下,所有配置均无法实现完全消融。将输入电压增加到 90 v,仅在 X-模型中扩大了凝血区。对于其他配置,将消融持续时间延长至 10 分钟被发现在扩大凝血区方面更好。

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作者列表:["Li Y","Wang Z","Jin J","Zhu SX","He GQ","Li SH","Wang J","Cai Y"]

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DOI:10.1097/COC.0000000000000609
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