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Prognostic role of visceral fat for overall survival in metastatic colorectal cancer: A pilot study.

内脏脂肪对转移性结直肠癌总生存期的预后作用: 一项初步研究。

  • 影响因子:4.77
  • DOI:10.1016/j.clnu.2020.05.019
  • 作者列表:"Basile D","Bartoletti M","Polano M","Bortot L","Gerratana L","Di Nardo P","Borghi M","Fanotto V","Pelizzari G","Lisanti C","Garutti M","Buriolla S","Ongaro E","Andreuzzi E","Montico M","Balestreri L","Miolo G","Toffoli G","Aprile G","Puglisi F","Buonadonna A
  • 发表时间:2020-05-23
Abstract

BACKGROUND:Body composition, has been established as a risk factor for colorectal cancer diagnosis and disease progression. Aim of this study was to investigate the prognostic role of adiposity, especially visceral fat (VAT), in patients (pts) with metastatic colorectal cancer (MCRC). MATERIAL AND METHODS:A retrospective cohort of 71 MCRC pts treated between 2013 and 2017 was evaluated. VAT was measured as cross-sectional (cm2) area at the L3 level divided by the square of the height (m2). A ROC analysis was performed to define a prognostic threshold according to VAT. RESULTS:Before first-line therapy start, 40 pts (56%) had a body mass index (BMI) > 25 kg/m2. The obtained cut-off value for VAT was 44. Median OS was 30.97 months. At univariate analysis, primary tumor resection (HR 0.40, p = 0.029), VAT>44 (HR 2.85, p = 0.011) and metastasectomy (HR 0.22, p = 0.005) were significantly associated with OS. By multivariate analysis, VAT>44 (HR 2.6; p = 0.020) and metastasectomy were still significantly associated with OS. CONCLUSION:This exploratory study suggests a prognostic role for VAT in MCRC pts, with higher VAT values predicting worse outcome.

摘要

背景: 身体成分已被确定为结直肠癌诊断和疾病进展的危险因素。本研究的目的是探讨肥胖,特别是内脏脂肪 (VAT) 在转移性结直肠癌 (MCRC) 患者 (pts) 中的预后作用。 材料和方法: 评价了 2013 年至 2017 年间接受治疗的 71 例 MCRC pts 的回顾性队列。VAT 测量为 L3 水平的横截面 (cm2) 面积除以高度 (m2) 的平方。进行 ROC 分析,根据 VAT 定义预后阈值。 结果: 在一线治疗开始前,40 例患者 (56%) 的体重指数 (BMI)> 25千克 kg/m2。获得的增值税临界值为 44。中位 OS 为 30.97 个月。在单变量分析中,原发肿瘤切除 (HR 0.40,p = 0.029) 、 VAT>44 (HR 2.85,p = 0.011) 和转移切除术 (HR 0.22,p = 0.005) 与 OS 显著相关。通过多变量分析,VAT>44 (HR 2.6; p = 0.020) 和转移切除术仍然与 OS 显著相关。 结论: 本探索性研究提示 VAT 在 MCRC pts 中的预后作用,VAT 值越高预测结局越差。

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发表时间:2020-01-30
来源期刊:The FEBS journal
DOI:10.1111/febs.15236
作者列表:["Sayed IM","Suarez K","Lim E","Singh S","Pereira M","Ibeawuchi SR","Katkar G","Dunkel Y","Mittal Y","Chattopadhyay R","Guma M","Boland BS","Dulai PS","Sandborn WJ","Ghosh P","Das S"]

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影响因子:3.72
发表时间:2020-01-21
DOI:10.1093/ibd/izz323
作者列表:["Prathapan KM","Ramos Rivers C","Anderson A","Koutroumpakis F","Koutroubakis IE","Babichenko D","Tan X","Tang G","Schwartz M","Proksell S","Johnston E","Hashash JG","Dunn M","Wilson A","Barrie A","Harrison J","Hartman D","Kim SC","Binion DG"]

METHODS:BACKGROUND:Peripheral blood eosinophilia (PBE) is a biomarker of an aggressive multiyear natural history in adults with inflammatory bowel diseases (IBDs). Additionally, PBE at diagnosis is associated with higher disease activity in pediatric-onset IBD. We sought to determine if PBE can function as a biomarker of long-term disease severity in pediatric-onset IBD patients who are followed into adulthood. METHODS:We analyzed a consented, prospective, natural history IBD registry at an adult tertiary center from 2009 to 2018. Prevalence of PBE was evaluated in both pediatric- and adult-onset IBD patients. Demographics, clinical characteristics, and health care utilization data were compared in patients with and without PBE. RESULTS:Among 2800 adult IBD patients, 23.4% had pediatric-onset disease. PBE was found in 34% of the pediatric-onset patients compared with 26.8% of the adult-onset IBD patients (P < 0.001). In the pediatric-onset IBD cohort, PBE was associated with higher rates of allergies (P < 0.0001), but not of asthma, allergic rhinitis, or primary sclerosing cholangitis. In the adult IBD patients with pediatric-onset disease, PBE was associated with higher rates of C-reactive protein elevation (P < 0.0001), erythrocyte sedimentation rate elevation (P < 0.0001), higher health care utilization, and higher average health care charges per year (P < 0.00001). CONCLUSIONS:Peripheral blood eosinophilia was more prevalent in adult IBD patients with pediatric-onset compared with adult-onset disease. Among all IBD patients with long-term follow-up, PBE defined a subgroup with more severe illness. These data suggest that PBE may be a biomarker for a high-risk subgroup with high cost trajectory and long-term severity in pediatric-onset IBD that persists into adulthood.

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影响因子:3.72
发表时间:2020-01-21
DOI:10.1093/ibd/izz331
作者列表:["Ronchetti S","Gentili M","Ricci E","Migliorati G","Riccardi C"]

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关键词: GILZ IBD 自身免疫 炎症
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