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Correlates of sleep quality and excessive daytime sleepiness in people with opioid use disorder receiving methadone treatment

接受美沙酮治疗的阿片类药物使用障碍患者睡眠质量与白天过度嗜睡的相关性

  • 影响因子:2.04
  • DOI:10.1007/s11325-020-02123-z
  • 作者列表:"Baldassarri, Stephen R.","Beitel, Mark","Zinchuk, Andrey","Redeker, Nancy S.","Oberleitner, David E.","Oberleitner, Lindsay M. S.","Carrasco, Danilo","Madden, Lynn M.","Lipkind, Nathan","Fiellin, David A.","Bastian, Lori A.","Chen, Kevin","Yaggi, H. Klar","Barry, Declan T.
  • 发表时间:2020-06-17
Abstract

Purpose The aim of this study was to evaluate the prevalence and clinical correlates of impaired sleep quality and excessive daytime sleepiness among patients receiving methadone for opioid use disorder (OUD). Methods Patients receiving methadone ( n  = 164) completed surveys assessing sleep quality (Pittsburgh Sleep Quality Index [PSQI]), daytime sleepiness (Epworth Sleepiness Scale [ESS]), and related comorbidities. We used bivariate and multivariable linear regression models to evaluate correlates of sleep quality and daytime sleepiness. Results Ninety percent of patients had poor sleep quality (PSQI >5), and the mean PSQI was high (11.0 ±4). Forty-six percent reported excessive daytime sleepiness (ESS > 10). In multivariable analyses, higher PSQI (worse sleep quality) was significantly associated with pain interference (coefficient = 0.40; 95% CI = 0.18–0.62; β  = 0.31), somatization (coefficient = 2.2; 95% CI = 0.75–3.6; β  = 0.26), and negatively associated with employment (coefficient = − 2.6; 95% CI = − 4.9 to − 0.19; β  = − 0.17). Greater sleepiness was significantly associated with body mass index (coefficient = 0.32; 95% CI = 0.18–0.46; β  = 0.33), and there was a non-significant association between sleepiness and current chronic pain (coefficient = 1.6; 95% CI = 0.26–3.5; β = 0.13; p value = 0.09). Conclusions Poor sleep quality and excessive daytime sleepiness are common in patients receiving methadone for OUD. Chronic pain, somatization, employment status, and obesity are potentially modifiable risk factors for sleep problems for individuals maintained on methadone. People with OUD receiving methadone should be routinely and promptly evaluated and treated for sleep disorders.

摘要

目的本研究的目的是评估接受美沙酮治疗阿片类药物使用障碍 (OUD) 患者中睡眠质量受损和白天过度嗜睡的患病率和临床相关因素。方法美沙酮患者 (n = 164) 完成了评估睡眠质量 (匹兹堡睡眠质量指数 [PSQI]) 、日间嗜睡 (Epworth 嗜睡量表 [ESS]) 和相关合并症的调查。我们使用双变量和多变量线性回归模型来评估睡眠质量和日间嗜睡的相关性。结果 11.0 的患者睡眠质量差 (PSQI >5),平均 PSQI 高 (± 4)。6% 报告白天过度嗜睡 (ESS> 10)。在多变量分析中,较高的 PSQI (较差的睡眠质量) 与疼痛干扰显著相关 (系数 = 0.40; 95% ci = 0.18-0.62; Β = 0.31),躯体化 (系数 = 2.2; 95% ci = 0.75-3.6; Β = 0.26),与就业负相关 (系数 = − 2.6; 95% ci =-4.9 至-0.19; Β =-0.17)。嗜睡程度与体重指数显著相关 (系数 = 0.32; 95% ci = 0.18-0.46; Β = 0.33),嗜睡与当前慢性疼痛之间无显著相关性 (系数 = 1.6; 95% ci = 0.26-3.5; Β = 0.13; P值 = 0.09)。结论在接受美沙酮治疗的患者中,睡眠质量差和白天过度嗜睡是常见的。慢性疼痛、躯体化、就业状况和肥胖是维持服用美沙酮的个体睡眠问题的潜在可改变的危险因素。接受美沙酮治疗的 OUD 患者应常规及时评估和治疗睡眠障碍。

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影响因子:4.30
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作者列表:["Bertrand SJ","Zhang Z","Patel R","O'Ferrell C","Punjabi NM","Kudchadkar SR","Kannan S"]

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