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Danhong Injection for the Treatment of Hypertensive Nephropathy: A Systematic Review and Meta-Analysis

丹红注射液治疗高血压肾病的系统评价和 Meta 分析

  • 影响因子:3.92
  • DOI:10.3389/fphar.2020.00909
  • 作者列表:"YiZhuo Li","Shihai Yan","Lichao Qian","Lihua Wu","Yawei Zheng","Zhuyuan Fang
  • 发表时间:2020-06-19
Abstract

ObjectiveDanhong Injection (DHI) has been widely used to treat various diseases in China for many years. The objective of this systematic review was to evaluate the efficacy of DHI combined with antihypertensive drugs for treatment of hypertensive nephropathy.MethodsSeven databases were searched from inception to September 21st, 2019. Randomized controlled trials comparing DHI combined with antihypertensive drugs versus antihypertensive drugs alone were extracted. The primary outcome was microalbuminuria (mALB). Secondary outcomes included systolic blood pressure (SBP), diastolic blood pressure (DBP), and serum creatinine (SCr).ResultsFifteen studies were included in the meta-analysis, which indicated that DHI combined with antihypertensive drugs has advantages compared with antihypertensive drugs alone for reducing mALB [weighted mean difference (WMD) = −12.86, 95% confidence interval (CI) (−14.72, −11.0), P < 0.01], lowering SBP [WMD = −2.84, 95% CI (−4.56, −1.12), P = 0.001] and DBP [WMD = −2.38, 95% CI (−4.34, −0.43), P = 0.017], and decreasing SCr [WMD = −40.45, 95% CI (−55.69, −25.21), P < 0.01].ConclusionThe combination of DHI with antihypertensive drugs appears to be more effective than antihypertensive drugs alone for treatment of hypertensive nephropathy. A moderate duration (≤4 weeks) of DHI administration is reasonable, and longer treatment with DHI should be avoided, according to the results of subgroup analysis.

摘要

目的安红注射液 (DHI) 在我国已广泛用于治疗多种疾病多年。本系统评价旨在评价 DHI 联合降压药治疗高血压肾病的疗效。方法检索 7 个数据库,检索时间为 2019 年 9 月 21 日。提取比较 DHI 联合降压药物与单独降压药物的随机对照试验。主要终点是微量白蛋白尿 (mALB)。次要结局包括收缩压 (SBP) 、舒张压 (DBP) 和血清肌酐 (SCr)。结果 15 项研究纳入 meta 分析,表明 DHI 联合降压药在降低 mALB [加权平均差 (WMD) =-12.86, 95% 置信区间(CI) (-14.72,-11.0),P <0.01],降低 SBP [WMD =-2.84,95% CI (-4.56,-1.12), P = 0.001] 和 DBP [WMD =-2.38,95% CI (-4.34,-0.43),P = 0.017],降低 SCr [WMD =-40.45,95% CI(-55.69,-25.21),P <0.01]。结论 DHI 联合降压药治疗高血压肾病较单用降压药更有效。根据亚组分析结果,给予 DHI 的中度持续时间 (≤ 4 周) 是合理的,应避免更长时间的 DHI 治疗。

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