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Renal clearable Hafnium-doped carbon dots for CT/Fluorescence imaging of orthotopic liver cancer.

用于原位肝癌 CT/荧光成像的肾脏可透明掺铪碳点。

  • 影响因子:9.85
  • DOI:10.1016/j.biomaterials.2020.120110
  • 作者列表:"Su Y","Liu S","Guan Y","Xie Z","Zheng M","Jing X
  • 发表时间:2020-06-08
Abstract

:Carbon dots (CDs) are emerging as powerful nanoprobes for multiple-model bioimaging. Nowadays, orthotopic xenograft models attract increasing attention because of their superiorities of duplicating the tumor microenvironment. However, compared with the extensive study of subcutaneous xenograft tumors, less attention has been paid to CDs for in vivo orthotopic tumor imaging. Furthermore, it is very desirable for a nanoprobe to achieve preferential accumulation at the tumor site and efficient renal clearance. In this work, a novel kind of Hafnium-doped CDs (HfCDs) were successfully prepared via a simple one-pot pyrolysis method. The significant advantages including robust stability, good biocompatibility, excellent water solubility, remarkable computed tomography (CT) contrast performance and preferential tumor accumulation capability endow HfCDs with particular functions of CT/fluorescence imaging of orthotopic liver cancer initially. More importantly, HfCDs could locate at the tumor site and achieve the rapid imaging within 1 min. The findings of the current study represent a facile and universal approach to fabricate outstanding renal clearable multimodal imaging nanoprobes with great potential for clinical diagnosis.

摘要

: 碳点 (CDs) 正在成为多模式生物成像的强大纳米探针。目前,原位异种移植模型因其复制肿瘤微环境的优势而受到越来越多的关注。然而,与皮下异种移植肿瘤的广泛研究相比,CDs 用于体内原位肿瘤成像的关注较少。此外,纳米探针在肿瘤部位实现优先积累和有效的肾清除是非常理想的。在这项工作中,通过简单的一锅热解方法成功地制备了一种新型的掺铪的 CDs (HfCDs)。显著的优点包括坚固的稳定性,良好的生物相容性,优良的水溶性,显著的计算机断层扫描 (CT) 对比性能和优先肿瘤积累能力赋予 HfCDs 最初原位肝癌 CT/荧光成像的特殊功能。更重要的是,HfCDs 可以定位在肿瘤部位,并在 1 min 内实现快速成像。当前研究的发现代表了一种简单而通用的方法,可以制造出出色的肾脏清晰多模态成像纳米探针,具有巨大的临床诊断潜力。

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影响因子:6.50
发表时间:2020-03-31
来源期刊:Cancer letters
DOI:10.1016/j.canlet.2019.12.039
作者列表:["Zhou Z","Zhou Q","Wu X","Xu S","Hu X","Tao X","Li B","Peng J","Li D","Shen L","Cao Y","Yang L"]

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