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Qingda granules attenuate hypertensive cardiac remodeling and inflammation in spontaneously hypertensive rats.

清达颗粒减轻自发性高血压大鼠高血压心脏重构和炎症。

  • 影响因子:3.78
  • DOI:10.1016/j.biopha.2020.110367
  • 作者列表:"Wu X","Shen A","Bao L","Wu M","Lin X","Wang H","Chen Y","Cai Q","Lin S","Zhou X","Lu Y","Peng M","Chen D","Chu J","Peng J
  • 发表时间:2020-06-16
Abstract

:Qingda granules (QDG) are derived from QingXuanJiangYa Decoction (QXJYD) a traditional Chinese medication that has been used to treat hypertension for more than 60 years. QXJYD has been shown to be effective in rat models of hypertension. However, the effects of QDG on hypertension remain largely unknown. In the current study, baicalin was identified as one of the main components of QDG using Ultra Performance Liquid Chromatography (UPLC) analysis. We investigated the effects of QDG on blood pressure, cardiac remodeling, and cardiac inflammation. QDG (0.8 g/kg/day) treatment attenuated the elevated blood pressure in spontaneously hypertensive rats (SHRs). Moreover, QDG treatment reduced the degree of myocardial fiber disarray, degeneration and necrosis of myocardial cells, expression of ANP and BNP, as well as collagen content of SHRs. Moreover, we further assessed the effect of QDG treatment on cardiac inflammation and found that QDG treatment reduced CD68 protein expression, decreased levels of IL-6 and TNF-α in both serum and cardiac tissues, as well as suppressed activation of NF-κB pathway in cardiac tissues of SHRs. Differential expressed metabolites (DEMs) analysis identified 41 increased and 51 decreased metabolites in the cardiac tissues of SHRs after QDG treatment. In summary, QDG treatment of SHRs attenuated the elevated blood pressure and ameliorated cardiac remodeling and inflammation, in part, through suppression of NF-κB pathway and DEMs, which provide a basis for other therapeutic uses of this TCM.

摘要

: 清达颗粒 (QDG) 来源于清宣降压汤 (QXJYD) 一种治疗高血压 60 余年的中药。QXJYD 已被证明对高血压大鼠模型有效。然而,QDG 对高血压的影响在很大程度上仍然未知。在目前的研究中,黄芩苷被确定为使用超高效液相色谱 (UPLC) 分析 QDG 的主要成分之一。我们研究了 QDG 对血压、心脏重塑和心脏炎症的影响。QDG (0.8g/kg/天) 治疗可减轻自发性高血压大鼠 (SHRs) 的血压升高。此外,QDG 治疗降低了心肌纤维紊乱程度、心肌细胞变性坏死、 ANP 和 BNP 的表达以及 shr 的胶原含量。此外,我们进一步评估了 QDG 治疗对心脏炎症的影响,发现 QDG 治疗可降低血清和心脏组织中 CD68 蛋白表达,降低 IL-6 和 TNF-α 水平。以及抑制 SHRs 心脏组织 NF-κ b 通路的激活。差异表达代谢物 (DEMs) 分析确定了 QDG 处理后 SHRs 心脏组织中 41 个代谢物增加,51 个代谢物减少。总之,QDG 治疗 SHRs 可部分通过抑制 NF-κ b 通路和 DEMs,减轻血压升高,改善心脏重构和炎症。为中医药的其他治疗应用提供了依据。

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