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Variation in the Bombesin Staining of Pulmonary Neuroendocrine Cells in Pediatric Pulmonary Disorders - A Useful Marker for Airway Maturity.

小儿肺部疾病中肺神经内分泌细胞蛙皮素染色的变化-气道成熟度的有用标记。

  • 影响因子:2.38
  • DOI:10.1002/ppul.24910
  • 作者列表:"Emiralioğlu N","Orhan D","Cinel G","Tuğcu GD","Yalçın E","Doğru D","Özçelik U","Griese M","Kiper N
  • 发表时间:2020-06-18
Abstract

OBJECTIVES:Pulmonary neuroendocrine cells (NEC) increase with the age due to pulmonary maturity. The aim of this study was to determine whether open lung biopsies from patients with interstitial lung diseases have increased pulmonary NEC compared with NEHI. Our second aim was to assess pulmonary NECs in the lung autopsy of children without lung disease who died from different causes. METHODS:Lung tissue of 5 infants with neuroendocrine cell hyperplasia of infancy (NEHI); 21 patients with pediatric interstitial lung disease (chILD); 17 lung autopsies of infants at varying age without lung disease were included. The percentage of the airways containing neuroendocrine cells, the average percentage of NECs per airway and the number of neuroendocrine bodies (NEBs) in each case were analyzed. RESULTS:The mean percentage of the airways containing neuroendocrine cells were 95% in NEHI group, 30% in chILD group, 89% under intrauterine 37 weeks, 70% between intrauterine 37-40 weeks, 52% at postnatal 4 days-6 months of autopsy ages. In NEHI group, diffuse NE cell distribution and large NEBs were noticed in the lung biopsy. In chILD group, neuroendocrine cells were dispersed, did not form clusters and NE cells showed solitary distribution. In lung autopsy group, linear NE cells were detected at younger aged fetuses and solitary distribution of NE cells was detected with the older increasing age. CONCLUSIONS:Our findings confirm that NECs are seen in many other childhood ILDs; NE cell hyperplasia may be a marker of decreased pulmonary development and NE cells decrease with the increasing age of the fetus during intrauterine life. This article is protected by copyright. All rights reserved.

摘要

目的: 肺成熟使肺神经内分泌细胞 (NEC) 随年龄增长而增加。本研究的目的是确定与 NEHI 相比,间质性肺疾病患者的开放性肺活检是否增加了肺 NEC。我们的第二个目的是在不同原因死亡的无肺病儿童的肺尸检中评估肺 NECs。 方法: 5 例婴儿期神经内分泌细胞增生 (NEHI) 患儿; 21 例儿童间质性肺疾病 (chILD) 患儿; 纳入 17 例不同年龄无肺部疾病婴儿的肺部尸检。分析每个病例中含有神经内分泌细胞的气道百分比、每个气道中 NECs 的平均百分比和神经内分泌体 (NEBs) 的数量。 结果: NEHI 组气道内含有神经内分泌细胞的平均百分比为 95%,chILD 组为 30%,宫内 37 周时为 89%,宫内 37 ~ 40 周时为 70%,52% 出生后 4 天-6 个月尸检年龄。NEHI 组肺活检可见弥漫性 NE 细胞分布,NEBs 较大。ChILD 组神经内分泌细胞分散,不形成簇,NE 细胞呈孤立分布。在肺尸检组中,在年龄较小的胎儿中检测到线性 NE 细胞,并且随着年龄的增长,检测到 NE 细胞的孤立性分布。 结论: 我们的研究结果证实 NECs 见于许多其他儿童期 ILDs; 宫内胎龄增加,NE 细胞增生可能是肺发育下降的标志,NE 细胞减少。本文受版权保护。保留所有权利。

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作者列表:["Vadillo C","Nieto MA","Romero-Bueno F","Leon L","Sanchez-Pernaute O","Rodriguez-Nieto MJ","Freites D","Jover JA","Álvarez-Sala JL","Abasolo L"]

METHODS:OBJECTIVES:To asses the clinical course in RA-related interstitial lung disease (RA-ILD) patients with and without rituximab (RTX). The influence of other variables was also evaluated. METHODS:A longitudinal multicentre study was conducted in RA diagnosed with ILD from 2007 until 2018 in Madrid. Patients were included in a registry [pNEumology RhEumatology Autoinmune diseases (NEREA)] from the time of ILD diagnosis. The main endpoint was functional respiratory impairment (FI), when there was a decline ≥5% in the predicted forced vital capacity compared with the previous one. Pulmonary function was measured at baseline and in follow-up visits every 6-12 months. The independent variable was therapy with RTX. Covariables included sociodemographic, clinical, radiological and other therapies. Survival techniques were used to estimate the incidence rate (IR) and 95% CI of functional impairment, expressed per 100 patient-semesters. Cox multivariate regression models were run to examine the influence of RTX and other covariates on FI. Results were expressed as the hazard ratio (HR) and CI. RESULTS:A total of 68 patients were included. FI occurred in 42 patients [IR 23.5 (95% CI 19, 29.1)] and 50% of them had FI within 1.75 years of an ILD diagnosis. A multivariate analysis showed that RTX exposure resulted in a lower risk of FI compared with non-exposure [HR 0.51 (95% CI 0.31, 0.85)]. Interstitial pneumonia, glucocorticoids, disease activity and duration also influenced FI. CONCLUSION:RA-ILD patients deteriorate over time, with the median time free of impairment being <2 years. Patients exposed to RTX had a higher probability of remaining free of FI compared with other therapies. Other factors have also been identified. Key words: rheumatoid arthritis, interstitial lung disease, observational study, rituximab and prognosis

翻译标题与摘要 下载文献
影响因子:4.40
发表时间:2020-01-01
DOI:10.1007/s00262-019-02431-8
作者列表:["Shibaki, Ryota","Murakami, Shuji","Matsumoto, Yuji","Yoshida, Tatsuya","Goto, Yasushi","Kanda, Shintaro","Horinouchi, Hidehito","Fujiwara, Yutaka","Yamamoto, Nobuyuki","Kusumoto, Masahiko","Yamamoto, Noboru","Ohe, Yuichiro"]

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翻译标题与摘要 下载文献
影响因子:4.04
发表时间:2020-01-25
来源期刊:New biotechnology
DOI:10.1016/j.nbt.2019.08.006
作者列表:["Sousa SA","Soares-Castro P","Seixas AMM","Feliciano JR","Balugas B","Barreto C","Pereira L","Santos PM","Leitão JH"]

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