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Anticoagulation delay does not affect the functional outcome of cerebral venous thrombosis.

抗凝延迟不影响脑静脉血栓形成的功能结局。

  • 影响因子:0.0000
  • DOI:10.18632/aging.103353
  • 作者列表:"Ji K","Wu L","Zhao W","Wu C","Xu Y","Duan J","Meng R","Yan F","Chen J","Wu D","Luo Y","Ji X
  • 发表时间:2020-06-18
Abstract

:Available knowledge about the impact of anticoagulation delay on outcomes of patients with cerebral venous thrombosis (CVT) is limited. We therefore assessed the factors influencing anticoagulation delay and investigated the effect of this delay on outcomes of CVT patients. Anticoagulation delay was defined as the time interval between symptom onset and anticoagulation initiation. The primary outcome was a modified Rankin Scale (mRS) score > 2 at the final follow-up. A total of 164 eligible patients were included. The median anticoagulation delay was 9 days. Cerebral hemorrhage on admission neuroimaging correlated with earlier anticoagulation (p = 0.040). Anticoagulation delay was not associated with poor functional outcome (mRS > 2), but it was associated with residual headache across the entire cohort (earlier anticoagulation: 15/76 [19.7%] vs. later anticoagulation: 28/79 [35.4%]; p = 0.029) and in the subgroup with isolated intracranial hypertension (earlier anticoagulation: 4/25 [16.0%] vs. later anticoagulation: 14/27 [51.9%]; p = 0.007). Anticoagulation delay was found to be common among patients with CVT. Anticoagulation delay was not associated with poor functional outcome, but may have led to an increased risk of residual headache across our entire cohort and in the subgroup with isolated intracranial hypertension.

摘要

: 关于抗凝延迟对脑静脉血栓形成 (CVT) 患者结局影响的现有知识有限。因此,我们评估了影响抗凝延迟的因素,并研究了这种延迟对 CVT 患者结局的影响。抗凝延迟定义为症状发作和抗凝开始之间的时间间隔。主要结局为最终随访时改良 Rankin 量表 (mRS) 评分> 2 分。共纳入 164 例符合条件的患者。中位抗凝延迟为 9 天。入院时脑出血神经影像学与早期抗凝相关 (p = 0.040)。抗凝延迟与不良功能结局无关 (mRS> 2),但与整个队列的残余头痛相关 (早期抗凝: 15/76 [19.7%] vs.后期抗凝: 28/79 [35.4%]; p = 0.029) 和孤立性颅内高压亚组 (早期抗凝: 4/25[16.0%] vs.后期抗凝: 14/27 [51.9%]; p = 0.007)。发现抗凝延迟在 CVT 患者中很常见。抗凝延迟与功能预后不良无关,但可能导致我们整个队列和孤立性颅内高压亚组中残留头痛的风险增加。

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影响因子:2.57
发表时间:2020-01-06
DOI:10.1007/s12031-019-01474-x
作者列表:["Cheng, Xiao","Yang, Ying-Lin","Li, Wei-Han","Liu, Man","Zhang, Shan-Shan","Wang, Yue-Hua","Du, Guan-Hua"]

METHODS:Cerebral ischemia-reperfusion (I/R) is characterized by initial transient cerebral ischemia followed by reperfusion. Various pathophysiological processes are involved in brain injury and functional recovery during cerebral I/R. There are few studies on dynamic metabolic process after cerebral I/R. The present study was to observe dynamic alteration of brain injury, functional recovery, and metabolites after cerebral I/R in rats and discover potential metabolic markers. The cerebral I/R model was established by middle cerebral artery occlusion (MCAO) for 90 min, following reperfusion in rats. The results of cerebral infarction area, cerebral edema, and behavior test showed that there were dynamic changes in brain injury and functional recovery at different periods after cerebral I/R. Further analysis showed that the brain injury was severe on the first day of cerebral I/R, and there was a significant functional recovery from the 7th day of cerebral I/R, followed by an aggravation trend of brain injury from the days 7 to 28. Furthermore, Matrix-assisted laser desorption ionization mass spectrometry imaging analysis showed that the expression of ATP, glucose, and citric acid on 7th day was the highest during cerebral I/R, which indicated that energy metabolism and oxidative phosphorylation played important roles during cerebral I/R. In addition, the untargeted metabolomic results showed that the level of isocitric acid, the ratio of oxyglutaric acid/glutamic acid, and the level of pyruvic acid associated with the TCA cycle were also the highest on the 7th day during cerebral I/R, which indicated that the transient spontaneous recovery of ischemic brain on the 7th day after ischemia-reperfusion might be related to oxidative phosphorylation and energy metabolism in the brain in this period. In conclusion, the results suggest that some small molecule metabolites participate in the brain injury and functional recovery during cerebral I/R, which is of great significance to the development of therapeutic drugs and diagnostic markers.

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影响因子:2.75
发表时间:2020-01-01
DOI:10.1007/s00702-019-02124-7
作者列表:["Wang, Xiaodong","Shi, Cunxian","Pan, Hongxia","Meng, Xiaowen","Ji, Fuhai"]

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