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Central nervous system neuroblastic tumor with FOXR2 activation presenting both neuronal and glial differentiation: a case report

伴 FOXR2 激活的中枢神经系统神经母细胞瘤同时呈现神经元和神经胶质分化 1 例

  • 影响因子:2.86
  • DOI:10.1007/s10014-020-00370-2
  • 作者列表:"Furuta, Takuya","Moritsubo, Mayuko","Muta, Hiroko","Koga, Motohisa","Komaki, Satoru","Nakamura, Hideo","Morioka, Motohiro","Ohshima, Koichi","Sugita, Yasuo
  • 发表时间:2020-06-13
Abstract

A subset of central nervous system neuroblastomas (CNS NB), rare primary embryonal CNS tumors, has been encompassed in CNS NB with FOXR2 activation (CNS NB- FOXR2 ) and usually shows the primitive neuronal architecture and occasional neurocytic differentiation. Here, we report a rare case of 3-year-old female with uncommon morphology of CNS embryonal tumor with FOXR2 activation presenting bidirectional differentiation to neurocytic small primitive cells and astrocytic spindle cells both of which are positive for synaptophysin and GFAP. Ultrastructural study also showed that there were presynaptic structure and intermediate filament in the tumor cells, suggesting glioneuronal differentiation. This case indicates the possibility of CNS neuroblastic tumor to differentiate neuronal and glial lineages.

摘要

中枢神经系统神经母细胞瘤 (CNS NB) 的一个子集,罕见的原发性胚胎性 CNS 肿瘤,已包含在 CNS NB 中,伴 FOXR2 激活 (CNS NB- FOXR2) 通常显示原始神经元结构和偶尔的神经细胞分化。在这里,我们报告一例罕见的 3 岁女性患者,其罕见形态为 CNS 胚胎性肿瘤,FOXR2 激活呈现双向分化为神经细胞小原始细胞和星形细胞梭形细胞,两者均阳性。突触素和 GFAP。超微结构研究还表明,肿瘤细胞内存在突触前结构和中间丝,提示胶质神经分化。该病例表明 CNS 神经母细胞瘤有可能区分神经元和神经胶质谱系。

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