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Head and neck osteosarcoma: CT and MR imaging features.

头颈部骨肉瘤: CT和MR成像特征。

  • 影响因子:2.24
  • DOI:10.1259/dmfr.20190202
  • 作者列表:"Luo Z","Chen W","Shen X","Qin G","Yuan J","Hu B","Lyu J","Wen C","Xu W
  • 发表时间:2020-02-01
Abstract

OBJECTIVE:This study aims to assess the CT and MRI features of head and neck osteosarcoma (HNO). METHODS:37 HNOs were identified, and the following imaging characteristics were reviewed on CT and MRI. RESULTS:A total of 37 patients(age 41.5 ± 15.0 years old; 16 males, 21 females) were included in the study. Tumours occurred in the maxilla (16, 43.2%), mandible (8, 21.6%), skull base (6, 16.2%), calvarium (5, 13.5%), paranasal sinuses (1, 2.7%) and cervical soft tissue (1, 2.7%). 16 patients received radiotherapy for nasopharyngeal carcinoma. Three patients (8.1%) developed osteosarcomas related to a primary bone disease. 16 of the (43.2%) tumours demonstrated lytic density on CT scans, followed by 13 (35.1%) showing mixed density and 7 (18.9%) with sclerotic density. Matrix mineralization was present in 32 (86.5%). 3 out of 24 (12.5%) tumours showed lamellar periosteal reactions, 21 out of 24 (87.5%) showed spiculated periosteal reactions. 12 tumours showed low signal intensities on T1WI, with 16 having heterogeneous signal intensities. 10 tumours showed high signal intensities on T2WI, and 18 showed heterogeneous signal intensities. With contrast-enhanced images, 3 tumours showed homogeneous enhancement (2 osteoblastic and 1 giant cell-rich), 18 tumours showed heterogeneous enhancement (13 osteoblastic, 4 fibroblastic and 1 giant cell-rich), and 7 tumours showed peripheral enhancement (6 chondroblastic and 1 osteoblastic). These tumours were characterized by soft tissue masses with a diameter of 5.6 ± 1.8 cm. CONCLUSIONS:HNO is a rare condition and is commonly associated with previous radiation exposure. This study provides age, sex distribution, location, CT and MRI features of HNO.

摘要

目的: 探讨头颈部骨肉瘤 (HNO) 的CT和MRI表现。 方法: 识别 37 例HNOs,并在CT和MRI上回顾以下影像学特征。 结果: 共 37 例患者 (年龄 41.5 ± 15.0 岁; 16 例男性,21 例女性) 纳入研究。肿瘤发生于上颌骨 (1 6,43.2%) 、下颌骨 (8,2 1。6% ), 颅base 6,1 6.2%),颅骨 (5,1 3.5% ), 副鼻窦 (1,2.7%) 和颈部软组织 (1,2.7%)。16 例接受鼻咽癌放射治疗。3 例患者 (8.1%) 发生与原发性骨病相关的骨肉瘤。16 例 (43.2%) 肿瘤在ct扫描中显示溶解密度,其次 13 例 (35.1%) 显示混合密度,7 例 (18.9%) 显示硬化密度。基质矿化存在于 32 (86.5%)。24 个肿瘤中有 3 个 (12.5%) 显示板层骨膜反应,24 个肿瘤中有 21 个 (87.5%) 显示毛刺状骨膜反应。12 例肿瘤在T1WI上呈低信号,16 例呈不均匀信号。10 例肿瘤T2WI呈高信号,18 例呈不均匀信号。增强图像,3 个肿瘤显示均匀增强 (2 个成骨细胞和 1 个巨细胞丰富),1 8 个肿瘤显示不均匀增强 (1 3 个成骨细胞,4 个成纤维细胞和 1 个巨细胞丰富),7 个肿瘤显示外周强化 (6 个成软骨细胞和 1 个成骨细胞)。这些肿瘤的特征是软组织肿块,直径为 5.6 ± 1.8 cm。 结论: HNO是一种罕见的疾病,通常与既往的辐射暴露有关。本研究提供了HNO的年龄、性别分布、部位、CT和MRI特征。

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DOI:10.1259/bjr.20180883
作者列表:["Tran S","Puric E","Walser M","Poel R","Datta NR","Heuberger J","Pica A","Marder D","Lomax N","Bolsi A","Morach P","Bachtiary B","Seddon BM","Schneider R","Bodis S","Weber DC"]

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影响因子:1.41
发表时间:2020-03-01
DOI:10.1177/1078155219842277
作者列表:["Gyori DJ","Bullington SM","Crawford BS","Vernon VP"]

METHODS:BACKGROUND:National guidelines recommend screening and treatment for cancer-related bone disease and continued monitoring of bone-modifying agents. It is unclear whether a standardized screening tool is utilized to identify eligible patients and ensure appropriate supportive care is implemented. The purpose of this study was to evaluate current prescribing practices and optimize management of bone-modifying agents. METHODS:A retrospective chart review was performed to identify patients who received hormone deprivation therapy or had bone metastases through Hematology/Oncology or Urology clinics from 1 November 2016 to 31 October 2017. The primary endpoints of this study were the incidence of completed baseline dual-energy X-ray absorptiometry (DEXA) scan for patients on hormone deprivation therapy and percent of patients started on a bone-modifying agent for the prevention of skeletal-related events secondary to bone metastasis. Secondary endpoints included percent of patients with dental examinations prior to initiation, adequate calcium and vitamin D supplementation, incidence of osteonecrosis of the jaw or flu-like symptoms and education, and percent of bisphosphonate doses appropriately adjusted based on renal function. RESULTS:A total of 375 patients were assessed for baseline DEXA scans and bone-modifying therapy. Of the 226 patients on hormone deprivation therapy, 111 (49%) patients were appropriately screened with a DEXA scan prior to initiation of hormone deprivation therapy. Among the 149 patients with bone metastases, only 94 (63.1%) patients were started on a bone-modifying agent. CONCLUSIONS:Opportunities have been identified to optimize management of patients with cancer-related bone disease. Implementation of standardized tools may increase the rate of appropriate screening and initiation of bone-modifying therapy when warranted.

翻译标题与摘要 下载文献
影响因子:2.83
发表时间:2020-01-01
DOI:10.1007/s00520-019-04843-9
作者列表:["Dohzono S","Sasaoka R","Takamatsu K","Hoshino M","Nakamura H"]

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骨肿瘤方向

骨肿瘤是发生于骨骼或其附属组织的肿瘤。有良性,恶性之分,良性骨肿瘤易根治,预后良好,恶性骨肿瘤发展迅速,预后不佳,死亡率高。

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