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SNP's in xenobiotic metabolism and male infertility.

SNP在异种生物代谢和男性不育中的作用。

  • 影响因子:1.79
  • DOI:10.1080/00498254.2019.1616850
  • 作者列表:"Hekim N","Gure MA","Metin Mahmutoglu A","Gunes S","Asci R","Henkel R
  • 发表时间:2020-03-01
Abstract

:1. Glutathione S-transferases (GST) and cytochrome P450s (CYPs) are xenobiotic metabolizing enzymes participating in the protection of cell. The present study aimed to investigate the relationship between polymorphisms of glutathione S-transferase M1 (GSTM1) null, glutathione S-transferase T1 (GSTT1) null, glutathione S-transferase P1 (GSTP1) Ile105Val, cytochrome P450 1A2 (CYP1A2) 734 C→A, cytochrome P450 2D6 (CYP2D6) 1934 G→A and male infertility.2. A total of 306 azoospermic or oligozoospermic infertile men and 129 normozoospermic or fertile controls were enrolled in the study. Multiplex polymerase chain reaction (PCR) or PCR-restriction fragment length polymorphism methods were used for genotyping. There was a significant relationship between male infertility and CYP2D6 GG genotype (p < 0.001). CYP1A2 AA genotype was slightly higher in the infertile group (p = 0.056).3. There was no association between GSTT1 null polymorphisms and male infertility (p = 0.068), GSTM1 null (p = 0.843) and GSTP1 Ile105Val (p = 0.192) genes. GSTM1 null genotype frequency was higher in azoospermic men (p = 0.009). Men carrying CYP1A2 AA genotype had higher risk of infertility risk (OR = 3.14; %95 CI = 1.16-8.54) in the smoker group.4. Our results demonstrated that polymorphisms of CYP2D6 and CYP1A2 may play a role in idiopathic male infertility in our sample population.

摘要

: 1.谷胱甘肽S-转移酶 (GST) 和细胞色素p450 (CYPs) 是参与细胞保护的外源性代谢酶。本研究旨在探讨谷胱甘肽S-转移酶M1 (GSTM1) 缺失、谷胱甘肽S-转移酶T1 (GSTT1) 缺失、谷胱甘肽S-转移酶P1 (GSTP1) 多态性之间的关系。ile105Val,细胞色素P450 1A2 (CYP1A2) 734 cc → a,细胞色素P450 2D6 (CYP2D6) 1934  g → a和男性推断。共纳入 306 例无精子症或少精子症不育男性和 129 例正常精子症或生育对照。采用多重聚合酶链反应 (PCR) 或PCR-限制性片段长度多态性方法进行基因分型。CYP2D6 GG基因型与男性不育有显著相关性 (p <0.001)。不育组CYP1A2 AA基因型略高 (p = 0.056)。GSTT1 null多态性与男性不育 (p = 0.068) 、GSTM1 null (p = 0.843) 和GSTP1 Ile105Val (p = 0.192) 基因无相关性。GSTM1 无效基因型频率在无精子症男性中较高 (p = 0.009)。携带CYP1A2 AA基因型的男性,吸烟组不孕不育风险较高 (OR = 3.14; % 95 ci = 1.16-8.54)。我们的结果证明CYP2D6 和CYP1A2 的多态性可能在我们样本人群的特发性男性不育中起作用。

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影响因子:1.79
发表时间:2020-03-01
DOI:10.1080/00498254.2019.1616850
作者列表:["Hekim N","Gure MA","Metin Mahmutoglu A","Gunes S","Asci R","Henkel R"]

METHODS::1. Glutathione S-transferases (GST) and cytochrome P450s (CYPs) are xenobiotic metabolizing enzymes participating in the protection of cell. The present study aimed to investigate the relationship between polymorphisms of glutathione S-transferase M1 (GSTM1) null, glutathione S-transferase T1 (GSTT1) null, glutathione S-transferase P1 (GSTP1) Ile105Val, cytochrome P450 1A2 (CYP1A2) 734 C→A, cytochrome P450 2D6 (CYP2D6) 1934 G→A and male infertility.2. A total of 306 azoospermic or oligozoospermic infertile men and 129 normozoospermic or fertile controls were enrolled in the study. Multiplex polymerase chain reaction (PCR) or PCR-restriction fragment length polymorphism methods were used for genotyping. There was a significant relationship between male infertility and CYP2D6 GG genotype (p < 0.001). CYP1A2 AA genotype was slightly higher in the infertile group (p = 0.056).3. There was no association between GSTT1 null polymorphisms and male infertility (p = 0.068), GSTM1 null (p = 0.843) and GSTP1 Ile105Val (p = 0.192) genes. GSTM1 null genotype frequency was higher in azoospermic men (p = 0.009). Men carrying CYP1A2 AA genotype had higher risk of infertility risk (OR = 3.14; %95 CI = 1.16-8.54) in the smoker group.4. Our results demonstrated that polymorphisms of CYP2D6 and CYP1A2 may play a role in idiopathic male infertility in our sample population.

翻译标题与摘要 下载文献
影响因子:1.27
发表时间:2020-01-01
DOI:10.1111/ppc.12392
作者列表:["Safaei Nezhad A","Ebrahimi L","Vakili MM","Kharaghani R"]

METHODS:PURPOSE:This study evaluated the effect of counseling based on the choice theory on irrational parenthood cognition (IPC)- and marital quality in infertile women. DESIGN AND METHODS:This randomized controlled trial was conducted on 50 primary infertile women in Zanjan, Iran. Stratified block randomization was used to allocate participants to groups. The intervention group received counseling, but the control group received routine care. Data were collected using the IPC and marital relationships quality based on the Glasser's choice theory. FINDINGS:A statistically significant difference was found between the groups in IPC (P = 0.005), but the difference in marital quality was not statically significant ( P = 0.085). PRACTICE IMPLICATIONS:Counseling can be used for decreasing IPC, but more interventions are needed to increase marital quality.

翻译标题与摘要 下载文献
影响因子:2.14
发表时间:2020-02-01
DOI:10.1007/s11427-019-9526-2
作者列表:["Liu D","Yan J","Qiao J"]

METHODS::A decrease in cancer deaths has resulted in the possibility of child bearing for many young adult cancer survivors. Most antitumor treatment modalities are detrimental to female fertility, and methods for fertility preservation before gonadotoxic treatment, including cryopreservation of oocytes, embryos and ovarian tissue, have therefore been developed. This review focuses on the ovarian function of cancer patients, the safety and efficacy of fertility preservation methods, and the pregnancy outcomes of these patients. Breast cancer and hematological tumors constitute the majority of cancers in reproductive-aged female oncology patients. Ovarian function may not be impacted by breast cancer cells, while in patients with hematological malignancies, decreases in anti-Müllerian hormone and antral follicle counts have been demonstrated. In most cases, patients can undergo ovarian stimulation without delaying treatment, and a new stimulation protocol known as dual stimulation, which may be more efficient, has now been developed. Birth outcomes are also acceptable in cancer patients.

翻译标题与摘要 下载文献
不孕症方向

不孕症分为男性不育和女性不孕,其首要病因诊断依次是:排卵障碍、精液异常、输卵管异常、不明原因的不孕、子宫内膜异位症和其他如免疫学不孕。

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