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Novel Example of a Direct-Agglutinating Anti-Ku.

直接凝集抗Ku的新例子。

  • 影响因子:0.85
  • DOI:10.1093/labmed/lmz021
  • 作者列表:"Gannett MS","Gammon RR
  • 发表时间:2020-01-02
Abstract

BACKGROUND:Several Kell-system antibodies are known to cause direct agglutination. Also, some specificities, such as anti-Ku, have been reported to react only via the indirect antiglobulin test (IAT). METHODS:Herein, we describe the case of a 61-year-old alloimmunized white woman who presented to an outside hospital with a gastrointestinal (GI) bleed and a "possible anti-Ku" was reported with 3+ reactivity at PEG-IAT and at Ficin-IAT; in addition to an unidentified cold antibody. Subsequently, when the patient presented to a second outside hospital, an anti-Ku that caused 3+ to 4+ reactions at saline-immediate spin (IS) was identified. The reactivity was evaluated with 0.01-M dithiothreitol (DTT) treatment of the plasma. RESULTS:It was determined that the strong agglutination with saline-IS was caused by immunoglobulin (Ig)M anti-Ku. CONCLUSION:To our knowledge, this is the first reported case of an IgM anti-Ku.

摘要

背景: 已知几种Kell系统抗体可引起直接凝集。此外,据报道,一些特异性,如抗Ku,仅通过间接抗球蛋白试验 (IAT) 反应。 方法: 在这里,我们描述了一个 61 岁的同种免疫白人妇女的病例,她在医院外就诊,患有胃肠道 (GI) 出血和 “可能的抗Ku” 被报道在PEG-IAT和Ficin-IAT有 3 + 反应性; 除了一种不明的冷抗体。随后,当患者就诊于第二家院外医院时,确定了在盐水立即旋转 (IS) 时引起 3 + 至 4 + 反应的抗Ku。用 0.01-M二硫苏糖醇 (DTT) 处理血浆评价反应性。 结果: 确定与盐水-IS的强凝集是由免疫球蛋白 (Ig)M抗-Ku引起的。 结论: 据我们所知,这是第一例报告的IgM抗Ku病例。

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影响因子:0.85
发表时间:2020-01-02
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