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Correlation between eosinophil count, its genetic background and body mass index: The Nagahama Study.

嗜酸性粒细胞计数及其遗传背景与体重指数的相关性: Nagahama研究。

  • 影响因子:2.66
  • DOI:10.1016/j.alit.2019.05.012
  • 作者列表:"Sunadome H","Matsumoto H","Izuhara Y","Nagasaki T","Kanemitsu Y","Ishiyama Y","Morimoto C","Oguma T","Ito I","Murase K","Muro S","Kawaguchi T","Tabara Y","Chin K","Matsuda F","Hirai T
  • 发表时间:2020-01-01
Abstract

BACKGROUND:Obesity affects the pathogenesis of various chronic diseases, including asthma. Research on correlations between obesity/BMI and eosinophilic inflammation in asthma has yielded contradictory results, which could be partly ascribed to the absence of epidemiological data on the correlations. We aimed to elucidate the correlations between blood eosinophil count, its genetic backgrounds, and BMI in the general population. METHODS:This community-based Nagahama study in Japan enrolled 9789 inhabitants. We conducted self-reporting questionnaires, lung function tests, and blood tests in the baseline and 5-year follow-up studies. A genome-wide association study (GWAS) was performed in 4650 subjects at the baseline and in 4206 of these at the follow-up to determine single-nucleotide polymorphisms for elevated blood eosinophil counts. We assessed the correlations between BMI and eosinophil counts using a multifaceted approach, including the cluster analysis. RESULTS:Eosinophil counts positively correlated with BMI, observed upon the interchange of an explanatory variable, except for subjects with the highest quartile of eosinophils (≥200/μL), in whom BMI negatively correlated with eosinophil counts. GWAS and human leukocyte antigen (HLA) imputation identified rs4713354 variant (MDC1 on chromosome 6p21) for elevated eosinophil counts, independent of BMI and IgE. Rs4713354 was accumulated in a cluster characterized by elevated eosinophil counts (mean, 498 ± 178/μL) but normal BMI. CONCLUSIONS:Epidemiologically, there may be a positive association between blood eosinophil counts and BMI in general, but there was a negative correlation in the population with high eosinophil counts. Factors other than BMI, particularly genetic backgrounds, may contribute to elevated eosinophil counts in such populations.

摘要

背景: 肥胖影响包括哮喘在内的多种慢性疾病的发病机制。关于肥胖/BMI与哮喘嗜酸性粒细胞炎症之间相关性的研究得出了矛盾的结果,这可能部分归因于缺乏关于相关性的流行病学数据。我们旨在阐明一般人群中血嗜酸性粒细胞计数、其遗传背景和BMI之间的相关性。 方法: 这项日本以社区为基础的Nagahama研究招募了 9789 名居民。我们在基线和 5 年随访研究中进行了自我报告问卷、肺功能测试和血液测试。在基线时对 4650 例受试者和随访时对其中 4206 例受试者进行了全基因组关联研究 (GWAS),以确定血嗜酸性粒细胞计数升高的单核苷酸多态性。我们使用多方面的方法,包括聚类分析,评估了BMI和嗜酸性粒细胞计数之间的相关性。 结果: 嗜酸性粒细胞计数与BMI呈正相关,在交换解释变量后观察到,嗜酸性粒细胞四分位数最高 (≥ 200/μ l) 的受试者除外,其中BMI与嗜酸性粒细胞计数呈负相关。GWAS和人类白细胞抗原 (HLA) 插补鉴定出rs4713354 变异体 (染色体 6p21 上的MDC1) 嗜酸性粒细胞计数升高,与BMI和IgE无关。Rs4713354 聚集在一个以嗜酸性粒细胞计数升高 (平均值,498 ± 178/μ l) 但BMI正常为特征的簇中。 结论: 在流行病学上,血嗜酸性粒细胞计数与BMI之间可能总体呈正相关,但在嗜酸性粒细胞计数较高的人群中呈负相关。BMI以外的因素,特别是遗传背景,可能导致此类人群嗜酸性粒细胞计数升高。

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METHODS::In a recent meta-analysis, we found that atopic diseases, like asthma and allergic rhinitis, occur more frequently prior to the onset of attention-deficit/hyperactivity disorder (ADHD). Our aim was to determine the temporal order of the association between daily fluctuations in atopic disease symptoms and in ADHD symptoms in individual participants. In this observational study among 21 participants, age 7-16 years, we performed a replicated time-series analysis of symptom fluctuations in asthma and/or allergic rhinitis and ADHD. Data were collected through parents who filled in a daily online questionnaire during up to 50 days. In each individual, we investigated the temporal order of fluctuations in atopic disease symptoms and ADHD symptoms using a vector autoregressive (VAR) model while using sleep problems and medication use as covariates. For 16 out of 21 participants, we constructed a VAR model. For a majority of the participants, significant associations were detected between atopic disease symptoms and ADHD symptoms. The results were heterogeneous; the direction, sign, and timing of the relationship between ADHD, atopy, sleep problems, and medication use varied between individuals. This study provides additional evidence that the symptom expression of atopy and ADHD are related. However, the connection between both diseases in children is found to be heterogeneous within our study population.

翻译标题与摘要 下载文献
影响因子:1.16
发表时间:2020-01-01
DOI:10.1080/19338244.2019.1606774
作者列表:["Whitworth KW","Berumen-Flucker B","Delclos GL","Fragoso S","Mata C","Gimeno Ruiz de Porras D"]

METHODS::The occupational hazards and respiratory symptoms of domestic cleaners in USA are largely unknown. We conducted a cross-sectional study among 56 Hispanic female domestic cleaner on their health status and frequency of cleaning products used and tasks performed. While women used multi-use products (60.0%) and toilet bowl cleaners (51.8%) most days of the week, many (39.3%) reported not using personal protective equipment while cleaning. Itchy/watery eyes (61.8%) and itchy nose (56.4%) were the most frequently reported symptoms. A history of physician-diagnosed asthma was reported by 14.3% while 33.9% had symptoms of bronchial hyperresponsiveness (BHR). In conclusion, this vulnerable population has high prevalence of physician-diagnosis asthma and BHR symptoms and is potentially exposed to myriad occupational hazards. Further research exploring associations between products use, cleaning tasks and respiratory symptoms is warranted.

翻译标题与摘要 下载文献
影响因子:2.66
发表时间:2020-01-01
DOI:10.1016/j.alit.2019.05.012
作者列表:["Sunadome H","Matsumoto H","Izuhara Y","Nagasaki T","Kanemitsu Y","Ishiyama Y","Morimoto C","Oguma T","Ito I","Murase K","Muro S","Kawaguchi T","Tabara Y","Chin K","Matsuda F","Hirai T"]

METHODS:BACKGROUND:Obesity affects the pathogenesis of various chronic diseases, including asthma. Research on correlations between obesity/BMI and eosinophilic inflammation in asthma has yielded contradictory results, which could be partly ascribed to the absence of epidemiological data on the correlations. We aimed to elucidate the correlations between blood eosinophil count, its genetic backgrounds, and BMI in the general population. METHODS:This community-based Nagahama study in Japan enrolled 9789 inhabitants. We conducted self-reporting questionnaires, lung function tests, and blood tests in the baseline and 5-year follow-up studies. A genome-wide association study (GWAS) was performed in 4650 subjects at the baseline and in 4206 of these at the follow-up to determine single-nucleotide polymorphisms for elevated blood eosinophil counts. We assessed the correlations between BMI and eosinophil counts using a multifaceted approach, including the cluster analysis. RESULTS:Eosinophil counts positively correlated with BMI, observed upon the interchange of an explanatory variable, except for subjects with the highest quartile of eosinophils (≥200/μL), in whom BMI negatively correlated with eosinophil counts. GWAS and human leukocyte antigen (HLA) imputation identified rs4713354 variant (MDC1 on chromosome 6p21) for elevated eosinophil counts, independent of BMI and IgE. Rs4713354 was accumulated in a cluster characterized by elevated eosinophil counts (mean, 498 ± 178/μL) but normal BMI. CONCLUSIONS:Epidemiologically, there may be a positive association between blood eosinophil counts and BMI in general, but there was a negative correlation in the population with high eosinophil counts. Factors other than BMI, particularly genetic backgrounds, may contribute to elevated eosinophil counts in such populations.

翻译标题与摘要 下载文献
支气管疾病方向

支气管疾病包括支气管哮喘、支气管肿瘤、支气管炎、支气管扩张、支气管痉挛、支气管囊肿等疾病。

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