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The temporal order of fluctuations in atopic disease symptoms and attention-deficit/hyperactivity disorder symptoms: a time-series study in ADHD patients.

特应性疾病症状和注意力缺陷/多动障碍症状波动的时间顺序: ADHD患者的时间序列研究。

  • 影响因子:3.51
  • DOI:10.1007/s00787-019-01336-2
  • 作者列表:"van der Schans J","Cao Q","Bos EH","Rours GIJG","Hoekstra PJ","Hak E","de Vries TW
  • 发表时间:2020-02-01
Abstract

:In a recent meta-analysis, we found that atopic diseases, like asthma and allergic rhinitis, occur more frequently prior to the onset of attention-deficit/hyperactivity disorder (ADHD). Our aim was to determine the temporal order of the association between daily fluctuations in atopic disease symptoms and in ADHD symptoms in individual participants. In this observational study among 21 participants, age 7-16 years, we performed a replicated time-series analysis of symptom fluctuations in asthma and/or allergic rhinitis and ADHD. Data were collected through parents who filled in a daily online questionnaire during up to 50 days. In each individual, we investigated the temporal order of fluctuations in atopic disease symptoms and ADHD symptoms using a vector autoregressive (VAR) model while using sleep problems and medication use as covariates. For 16 out of 21 participants, we constructed a VAR model. For a majority of the participants, significant associations were detected between atopic disease symptoms and ADHD symptoms. The results were heterogeneous; the direction, sign, and timing of the relationship between ADHD, atopy, sleep problems, and medication use varied between individuals. This study provides additional evidence that the symptom expression of atopy and ADHD are related. However, the connection between both diseases in children is found to be heterogeneous within our study population.

摘要

: 在最近的一项荟萃分析中,我们发现特应性疾病,如哮喘和过敏性鼻炎,在注意力缺陷/多动障碍 (ADHD) 发作之前更频繁地发生。我们的目的是确定个体参与者中特应性疾病症状和ADHD症状的每日波动之间关联的时间顺序。在这项观察性研究中,21 名参与者,年龄 7-16 岁,我们对哮喘和/或过敏性鼻炎和ADHD的症状波动进行了重复的时间序列分析。通过家长在长达 50 天内填写每日在线问卷收集数据。在每个个体中,我们使用向量自回归 (VAR) 模型研究了特应性疾病症状和ADHD症状波动的时间顺序,同时使用睡眠问题和药物使用作为协变量。对于 21 名参与者中的 16 名,我们构建了VAR模型。对于大多数参与者,在特应性疾病症状和ADHD症状之间检测到显著的关联。结果具有异质性; ADHD、特应性、睡眠问题和药物使用之间关系的方向、标志和时间因个体而异。本研究提供了特应性症状表现与ADHD相关的额外证据。然而,在我们的研究人群中,发现儿童两种疾病之间的联系是异质性的。

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DOI:10.1007/s00787-019-01336-2
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METHODS::In a recent meta-analysis, we found that atopic diseases, like asthma and allergic rhinitis, occur more frequently prior to the onset of attention-deficit/hyperactivity disorder (ADHD). Our aim was to determine the temporal order of the association between daily fluctuations in atopic disease symptoms and in ADHD symptoms in individual participants. In this observational study among 21 participants, age 7-16 years, we performed a replicated time-series analysis of symptom fluctuations in asthma and/or allergic rhinitis and ADHD. Data were collected through parents who filled in a daily online questionnaire during up to 50 days. In each individual, we investigated the temporal order of fluctuations in atopic disease symptoms and ADHD symptoms using a vector autoregressive (VAR) model while using sleep problems and medication use as covariates. For 16 out of 21 participants, we constructed a VAR model. For a majority of the participants, significant associations were detected between atopic disease symptoms and ADHD symptoms. The results were heterogeneous; the direction, sign, and timing of the relationship between ADHD, atopy, sleep problems, and medication use varied between individuals. This study provides additional evidence that the symptom expression of atopy and ADHD are related. However, the connection between both diseases in children is found to be heterogeneous within our study population.

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呼吸过敏性疾病方向

当空气中的花粉、细菌等过敏原通过呼吸作用进入到肺部,就容易引起鼻子、咽喉、气管等部位出现不适的症状,可能引发多种呼吸过敏性疾病的发作。其中主要包括外源性过敏性肺泡炎、变应性支气管肺曲霉菌病、哮喘及过敏性鼻炎。

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