Epidemiological and clinical characteristics of 136 cases of COVID-19 in main district of Chongqing.
重庆市主城区 136 例新型冠状病毒肺炎流行病学及临床特征分析
- 作者列表："Chen P","Zhang Y","Wen Y","Guo J","Jia J","Ma Y","Xu Y
BACKGROUND:We did a comprehensive exploration of the epidemiological and clinical characteristics of 136 patients with confirmed COVID-19 in main district of Chongqing which was adjacent to the west of Hubei province. METHODS:This study was conducted on 136 patients with COVID-19 in main district of Chongqing from Jan 25 to Feb 20, 2020. Data of patients included demographic, epidemiological, clinical features, chest radiographs of imported cases, local cases, second-generation cases and third-generation cases. Student's t-test was adopted for quantitative variables while Pearson Chi-squared test or Fisher's exact test for categorical variables. RESULTS:The median age was 47 years and common symptoms of illness were cough (50.7%), fever (47.1%) and fatigue (14.0%). The time from contact symptomatic case to illness was 7.7 days, and 88 patients (64.7%) were cluster cases, radiological evidence found bilateral lung involvement was common (57.4%).Compared with the imported cases, the local cases were significantly older, the proportion of men is lower. There was higher proportion of cluster cases in local cases. Unlike imported cases, which fever was the dominant symptom, the local cases have more cough patients, with a significant higher proportion of asymptomatic patients. The third-generation cases have a significant higher proportion of asymptomatic patients. CONCLUSION:We concluded the epidemiological and clinical characteristics of the cases andsuggested to take more comprehensive measures for screening patients, especially for elderly person, avoid family gatherings, and implement more closely surveillance of suspect patients and their close contacts.
背景: 我们对毗邻鄂西的重庆市主城区 136 例确诊新型冠状病毒肺炎的流行病学和临床特征进行了综合分析。 方法: 对重庆市主城区 2020 年 1 月 25 日-2 月 20 日的 136 例新型冠状病毒肺炎患者进行研究。患者资料包括人口学、流行病学、临床特征、输入病例胸片、本地病例、第二代病例和第三代病例。S t uden t的t-test t被解吸剂，解吸t ed的全t i t一t我变量尽管皮尔逊卡方test t或Fisher exac t test t ca t egorical变量。 结果: 患者中位年龄 47 岁，常见症状为咳嗽 (50.7%) 、发热 (47.1%) 和乏力 (14.0%)。从接触症状病例到患病时间为 7.7 天，88 例患者 (64.7%) 为聚集性病例，放射学证据发现双侧肺受累常见 (57.4%)。与输入病例相比，本地病例年龄明显较大，男性比例较低。本地病例中聚集性病例比例较高。与以发热为主要症状的输入性病例不同，当地病例咳嗽患者较多，无症状患者比例明显较高。第三代病例中无症状患者的比例明显较高。 结论: 总结病例的流行病学和临床特点，建议采取更全面的措施对患者进行筛查，特别是对老年人，避免家庭聚会，对可疑患者及其密切接触者实施更密切的监测。
METHODS::Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.
METHODS::In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. Likewise, patient will be released upon two times of negative detection from oral swabs. However, many coronaviruses can also be transmitted through oral-fecal route by infecting intestines. Whether 2019-nCoV infected patients also carry virus in other organs like intestine need to be tested. We conducted investigation on patients in a local hospital who were infected with this virus. We found the presence of 2019-nCoV in anal swabs and blood as well, and more anal swab positives than oral swab positives in a later stage of infection, suggesting shedding and thereby transmitted through oral-fecal route. We also showed serology test can improve detection positive rate thus should be used in future epidemiology. Our report provides a cautionary warning that 2019-nCoV may be shed through multiple routes.
METHODS::There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of information are crucial to risk assessments and beginning outbreak control activities. This information should include reports from outbreak sites and from laboratories supporting the investigation. This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. In addition, by fitting the number of infections with a single-term exponential model, we report that the infection is spreading at an exponential rate, with a doubling period of 1.8 days.