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Impact of Epstein-Barr virus coinfection in Mycoplasma pneumoniae pneumonia.

影响Epstein-Barr病毒共感染支原体 (mp) 肺炎 (肺炎.

  • 影响因子:1.95
  • DOI:10.1097/MD.0000000000019792
  • 作者列表:"Xu Y","Li S","Liu J","Zhou J","Jin F","Chen X","Wang Y","Jiang Y","Chen Z
  • 发表时间:2020-04-01
Abstract

:Mycoplasma pneumoniae (MP) is one of the most common pathogens of respiratory infection in children, while Epstein-Barr virus (EBV) infection is usually subclinical in immunocompetent children. Although single MP infection is common enough, MP and EBV coinfection have received little attention. Especially, the pathogenic role of EBV in lung when coinfection with MP, has not been clarified. The purpose of this study was to investigate the impact of EBV on MP pneumonia (MPP) in hospitalized children. We retrospectively reviewed the clinical data of MPP children who underwent screening for EBV by polymerase chain reaction in bronchoalveolar lavage fluid during hospitalization in 2014. Of total 147 patients, 68 patients were in the MP group and 79 were in the MP/EBV coinfection group. We found longer fever duration and higher CRP, IgA, IgG, interleukin-2 (IL-2), percentage of peripheral neutrophils levels, higher incidence of pulmonary consolidation and percentage of refractory MPP in coinfection group, when compared to those in MP group. In ROC curve analysis, IL-2 was useful for differentiating patients with coinfection from those with MP infection. Logistic regression analysis showed that the IL-2 ≥ 3.35 pg/ml (OR = 3.677) was a significant predictor regarding to MP/EBV coinfection. In conclusion, coinfection of EBV and MP poses a higher risk for prolonged symptoms. IL-2 could be used as a good predictor of coinfection.

摘要

: 肺炎支原体 (MP) 是最常见的病原呼吸道感染儿童,而Epstein-Barr病毒 (EBV) 感染通常是亚临床免疫功能正常的孩子.虽然单一的MP感染已经足够普遍,但MP和EBV共感染很少受到关注。特别是与MP共感染时,EBV在肺部的致病作用尚未阐明。本研究的目的是探讨EBV对住院儿童MP肺炎 (MPP) 的影响。我们回顾性分析 2014 年住院期间接受支气管肺泡灌洗液聚合酶链反应筛查EBV的MPP患儿的临床资料。147 例患者中,MP组 68 例,MP/EBV共感染组 79 例。我们发现合并感染组发热持续时间更长,CRP、IgA、IgG、interleukin-2 (IL-2) 、外周血中性粒细胞百分比、肺实变发生率更高,难治性MPP百分比更高,与MP组相比。在ROC曲线分析中,IL-2 有助于鉴别合并感染和MP感染。Logistic回归分析显示,IL-2 ≥ 3.35 pg/ml (or = 3.677) 是MP/EBV合并感染的显著预测因子。总之,EBV和MP的合并感染导致症状持续时间延长的风险较高。IL-2 可作为合并感染的良好预测因子。

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呼吸道感染方向

呼吸道感染分为上呼吸道感染与下呼吸道感染。上呼吸道感染是指自鼻腔至喉部之间的急性炎症的总称,是最常见的感染性疾病。下呼吸道感染是最常见的感染性疾患,治疗时必须明确引起感染的病原体以选择有效的抗生素。

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