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Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic.

流感和肥胖: 其奇怪的关系和新型冠状病毒肺炎大流行的教训。

  • 影响因子:2.86
  • DOI:10.1007/s00592-020-01522-8
  • 作者列表:"Luzi L","Radaelli MG
  • 发表时间:2020-06-01
Abstract

AIMS:Analyze the relationship between obesity and influenza. METHODS:Basal hormone milieu, defective response of both innate and adaptive immune system and sedentariness are major determinants in the severity of influenza viral infection in obese patients. Being overweight not only increases the risk of infection and of complications for the single obese person, but a large prevalence of obese individuals within the population might increase the chance of appearance of more virulent viral strain, prolongs the virus shedding throughout the total population and eventually might increase overall mortality rate of an influenza pandemic. RESULTS:Waiting for the development of a vaccination against COVID-19, isolation of positive cases and social distancing are the primary interventions. Nonetheless, evidence from previous influenza pandemics suggests the following interventions aimed at improving immune response: (1) lose weight with a mild caloric restriction; (2) include AMPK activators and PPAR gamma activators in the drug treatment for obesity associated with diabetes; and (3) practice mild-to-moderate physical exercise. CONCLUSIONS:Due to prolonged viral shedding, quarantine in obese subjects should likely be longer than normal weight individuals.

摘要

目的: 分析肥胖与流感的关系。 方法: 基础激素环境、固有免疫和适应性免疫系统的缺陷反应以及镇静是肥胖患者流感病毒感染严重程度的主要决定因素。超重不仅会增加单一肥胖者感染和并发症的风险,而且人群中肥胖个体的大量流行可能会增加出现毒性更强的病毒株的机会,延长病毒在整个人口中的脱落,最终可能会增加流感大流行的总体死亡率。 结果: 等待新型冠状病毒肺炎疫苗接种的发展,阳性病例的隔离和社会疏远是主要的干预措施。尽管如此,以往流感大流行的证据表明,以下干预措施旨在改善免疫反应 :( 1) 轻度热量限制减肥; (2) 将AMPK激活剂和PPAR γ 激活剂纳入糖尿病相关肥胖的药物治疗中; 以及 (3) 练习轻中度体育锻炼。 结论: 由于长期病毒脱落,肥胖受试者的检疫可能比正常体重个体更长。

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翻译标题与摘要 下载文献
影响因子:2.48
发表时间:2020-04-01
来源期刊:Infection
DOI:10.1007/s15010-020-01401-y
作者列表:["Cheng ZJ","Shan J"]

METHODS::There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of information are crucial to risk assessments and beginning outbreak control activities. This information should include reports from outbreak sites and from laboratories supporting the investigation. This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. In addition, by fitting the number of infections with a single-term exponential model, we report that the infection is spreading at an exponential rate, with a doubling period of 1.8 days.

呼吸道感染方向

呼吸道感染分为上呼吸道感染与下呼吸道感染。上呼吸道感染是指自鼻腔至喉部之间的急性炎症的总称,是最常见的感染性疾病。下呼吸道感染是最常见的感染性疾患,治疗时必须明确引起感染的病原体以选择有效的抗生素。

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