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Lung under attack by COVID-19-induced cytokine storm: pathogenic mechanisms and therapeutic implications.

COVID-19-induced细胞因子风暴攻击下的肺: 致病机制和治疗意义。

  • 影响因子:2.93
  • DOI:10.1177/1753466620933508
  • 作者列表:"Pelaia C","Tinello C","Vatrella A","De Sarro G","Pelaia G
  • 发表时间:2020-01-01
Abstract

:The lung is a key target of the cytokine storm that can be triggered by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for the widespread clinical syndrome known as coronavirus disease 2019 (COVID-19). Indeed, in some patients, SARS-CoV-2 promotes a dysfunctional immune response that dysregulates the cytokine secretory pattern. Hypercytokinemia underlies the hyperinflammatory state leading to injury of alveolar epithelial cells and vascular endothelial cells, as well as to lung infiltration sustained by neutrophils and macrophages. Within such a pathogenic context, interleukin-6 (IL-6) and other cytokines/chemokines play a pivotal pro-inflammatory role. Therefore, cytokines and their receptors, as well as cytokine-dependent intracellular signalling pathways can be targeted by potential therapies aimed to relieve the heavy burden of cytokine storm. In particular, the anti-IL-6-receptor monoclonal antibody tocilizumab is emerging as one of the most promising pharmacologic treatments. The reviews of this paper are available via the supplemental material section.

摘要

: 肺是细胞因子风暴的关键靶点,可由严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2) 触发,负责广泛的临床综合征称为冠状病毒疾病 2019 (新型冠状病毒肺炎)。事实上,在一些患者中,SARS-CoV-2 促进功能失调的免疫反应,失调细胞因子分泌模式。高细胞因子血症是导致肺泡上皮细胞和血管内皮细胞损伤以及中性粒细胞和巨噬细胞持续肺浸润的高炎症状态的基础。在这样的致病性方面,interleukin-6 (IL-6) 等细胞因子/趋化因子起到至关重要的促炎作用.因此,细胞因子及其受体,以及细胞因子依赖的细胞内信号通路可以被旨在缓解细胞因子风暴的沉重负担的潜在疗法所靶向。特别是,anti-IL-6-receptor单克隆抗体tocilizumab正在成为最有前途的药物治疗之一。本文的评论可通过补充材料部分获得。

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DOI:10.3346/jkms.2020.35.e79
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翻译标题与摘要 下载文献
影响因子:2.48
发表时间:2020-04-01
来源期刊:Infection
DOI:10.1007/s15010-020-01401-y
作者列表:["Cheng ZJ","Shan J"]

METHODS::There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of information are crucial to risk assessments and beginning outbreak control activities. This information should include reports from outbreak sites and from laboratories supporting the investigation. This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. In addition, by fitting the number of infections with a single-term exponential model, we report that the infection is spreading at an exponential rate, with a doubling period of 1.8 days.

呼吸道感染方向

呼吸道感染分为上呼吸道感染与下呼吸道感染。上呼吸道感染是指自鼻腔至喉部之间的急性炎症的总称,是最常见的感染性疾病。下呼吸道感染是最常见的感染性疾患,治疗时必须明确引起感染的病原体以选择有效的抗生素。

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