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Could Sex/Gender Differences in ACE2 Expression in the Lungs Contribute to the Large Gender Disparity in the Morbidity and Mortality of Patients Infected With the SARS-CoV-2 Virus?

可以按性别/性别差异ACE2 表达肺部贡献大的性别差异的发病率和死亡率感染患者的SARS-CoV-2 病毒?

  • 影响因子:3.62
  • DOI:10.3389/fcimb.2020.00327
  • 作者列表:"Majdic G
  • 发表时间:2020-06-09
Abstract

:COVID-19 morbidity and mortality have significant gender disparities, with higher prevalence and mortality in men. SARS-CoV-2 enters the lungs through the ACE2 enzyme, a member of the renin-angiotensin system (RAS). Although there are no data for the lung, the expressions of RAS components in other tissues are modulated by sex hormones, androgens, and estrogens. However, there are no data on sex-specific differences in ACE2 expression. If there is a sex difference in the expression of ACE2 in the lung, this could theoretically explain the gender disparity in COVID-19 disease. More importantly, although modulation of ACE2 will certainly not provide a cure for the COVID-19 disease, modulation of ACE2 by sex hormone modulators, if they affect the expression of ACE2, could potentially be developed into a supportive therapy for COVID-19 patients.

摘要

: 新型冠状病毒肺炎发病率和死亡率存在显著的性别差异,男性发病率和死亡率较高。SARS-CoV-2 通过肾素-血管紧张素系统 (RAS) 的成员ACE2 酶进入肺部。虽然没有肺的数据,但其他组织中RAS成分的表达受到性激素、雄激素和雌激素的调节。然而,没有关于ACE2 表达的性别特异性差异的数据。如果肺中ACE2 的表达存在性别差异,理论上可以解释新型冠状病毒肺炎疾病的性别差异。更重要的是,尽管调节ACE2 肯定不能治愈新型冠状病毒肺炎疾病,但性激素调节剂调节ACE2,如果它们影响ACE2 的表达,有可能发展成为新型冠状病毒肺炎患者的支持疗法。

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影响因子:2.48
发表时间:2020-04-01
来源期刊:Infection
DOI:10.1007/s15010-020-01401-y
作者列表:["Cheng ZJ","Shan J"]

METHODS::There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of information are crucial to risk assessments and beginning outbreak control activities. This information should include reports from outbreak sites and from laboratories supporting the investigation. This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. In addition, by fitting the number of infections with a single-term exponential model, we report that the infection is spreading at an exponential rate, with a doubling period of 1.8 days.

呼吸道感染方向

呼吸道感染分为上呼吸道感染与下呼吸道感染。上呼吸道感染是指自鼻腔至喉部之间的急性炎症的总称,是最常见的感染性疾病。下呼吸道感染是最常见的感染性疾患,治疗时必须明确引起感染的病原体以选择有效的抗生素。

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