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Effectiveness, immunogenicity, and safety of influenza vaccines with MF59 adjuvant in healthy people of different age groups: A systematic review and meta-analysis.

MF59 佐剂流感疫苗在不同年龄组健康人群中的有效性、免疫原性和安全性: 系统综述和荟萃分析。

  • 影响因子:1.95
  • DOI:10.1097/MD.0000000000019095
  • 作者列表:"Yang J","Zhang J","Han T","Liu C","Li X","Yan L","Yang B","Yang X
  • 发表时间:2020-02-01
Abstract

BACKGROUND:Influenza is a severe disease burden among all age groups. This study aimed to review the efficacy of inactivated influenza vaccines with MF59 adjuvant and non-adjuvanted inactivated influenza vaccines among all age groups against specific influenza vaccine strains. METHODS:Literature search of PubMed, Embase, Medline, OVID, and Cochrane Library Trials (CENTRAL) was implemented up to March 1, 2019. Homogeneity qualified studies were included forData were extracted such as study country location, demographic characteristics, and measure outcomes, and were analyzed by a random effect model and sensitivity analyses to identify heterogeneity. Risk of bias was evaluated using the Cochrane Risk of Bias Tool. RESULTS:We retrieved 1,021 publications and selected 31 studies for full review, including 17 trials for meta-analysis and 6 trials for qualitative synthesis. MF59-adjuvanted influenza vaccines demonstrated better immunogenicity against specific vaccine virus strains compared to non-adjuvanted influenza vaccine both in healthy adult group (RR = 2.10; 95% CI: 1.28-3.44) and the healthy aged (RR = 1.26; 95% CI: 1.10-1.44). CONCLUSION:The quality of evidence is moderate to high for seroconversion and seroprotection rates of influenza vaccine. MF59-adjuvanted influenza vaccines are superior to non-adjuvanted influenza vaccines to enhance immune responses of vaccination in healthy adults and older adults, and could be considered for routine use especially the monovalent prepandemic influenza vaccines.

摘要

背景: 流感是所有年龄组的严重疾病负担。本研究旨在综述MF59 佐剂灭活流感疫苗和非佐剂灭活流感疫苗在所有年龄组中对特定流感疫苗株的效力。 方法: 对PubMed、Embase、Medline、OVID和Cochrane Library试验 (CENTRAL) 进行文献检索,检索时间截至 20 1 9 年 3 月 1 日。纳入同质性合格研究,提取数据,如研究国家位置、人口统计学特征和测量结果,并通过随机效应模型和敏感性分析进行分析,以确定异质性。使用Cochrane偏倚风险工具评价偏倚风险。 结果: 我们检索了 1,021 篇出版物,选择了 31 项研究进行全面综述,包括 17 项荟萃分析试验和 6 项定性综合试验。在健康成人组中,与非佐剂流感疫苗相比,MF59-adjuvanted流感疫苗对特定疫苗病毒株表现出更好的免疫原性 (rr = 2.10; 95% CI: 1.28-3.44) 和健康老年人 (rr = 1.26; 95% CI: 1.10-1.44)。 结论: 流感疫苗的血清转换率和血清保护率证据质量为中度至高度。MF59-adjuvanted流感疫苗优于非佐剂流感疫苗,可增强健康成人和老年人接种疫苗的免疫反应,可考虑常规使用,尤其是单价流感前期疫苗。

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呼吸道感染方向

呼吸道感染分为上呼吸道感染与下呼吸道感染。上呼吸道感染是指自鼻腔至喉部之间的急性炎症的总称,是最常见的感染性疾病。下呼吸道感染是最常见的感染性疾患,治疗时必须明确引起感染的病原体以选择有效的抗生素。

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