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Pregnancy outcomes in DMARD-exposed patients with juvenile idiopathic arthritis-results from a JIA biologic registry.

DMARD暴露的幼年特发性关节炎患者的妊娠结局-来自JIA生物登记的结果。

  • 影响因子:3.51
  • DOI:10.1093/rheumatology/kez309
  • 作者列表:"Drechsel P","Stüdemann K","Niewerth M","Horneff G","Fischer-Betz R","Seipelt E","Spähtling-Mestekemper S","Aries P","Zink A","Klotsche J","Minden K
  • 发表时间:2020-03-01
Abstract

OBJECTIVES:To investigate the courses and outcomes of pregnancies involving JIA patients who were exposed to DMARDs. METHODS:In the Juvenile arthritis MTX/Biologics long-term Observation study, pregnant patients or male patients with pregnant partners were identified. Standardized patient interviews were conducted, and the course and outcome of pregnancy were assessed. Prospectively collected physician- and patient-reported data were also considered in the analysis. RESULTS:The study sample included 152 pregnancies in 98 women with JIA and 39 pregnancies involving 21 male patients as partners. The majority of patients had polyarticular-onset/-course JIA (61%). The average age of patients at first pregnancy was 24.1 (4.5) years, and their mean disease duration was 13.8 (5.9) years. Patients had been exposed to DMARDs for 9.5 (5.6) years, and 90% of these patients had received biologics before. Half of the pregnancies occurred during DMARD exposure, mostly with etanercept. Significant differences in pregnancy outcomes between DMARD-exposed and -unexposed pregnancies were not observed. Spontaneous abortion (13.1%) and congenital anomaly (3.6%) rates were not suggestive of increased risk compared with expected background rates. However, the rates of premature birth (12.3%) and caesarean section (37.7%) were slightly above those in the German birthing population. The disease activity of female patients remained relatively stable in pregnancy, with mean cJADAS-10 scores of 5.3, 7.1 and 5.6 in each trimester, respectively. CONCLUSION:Young adults with JIA often become pregnant or become fathers of children while still being treated with DMARDs. Data suggest no increased risk of major adverse pregnancy outcomes.

摘要

目的: 探讨DMARDs暴露的JIA患者的妊娠过程和结局。 方法: 在幼年关节炎MTX/生物制剂长期观察研究中,确定妊娠患者或男性患者与妊娠伴侣。进行标准化患者访谈,评估妊娠过程和结局。分析中还考虑了前瞻性收集的医生和患者报告数据。 结果: 研究样本包括 98 例JIA妇女的 152 例妊娠和 39 例妊娠,包括 21 例男性患者作为伴侣。大多数患者为多关节起病/病程JIA (61%)。患者初次妊娠的平均年龄为 24.1 (4.5) 岁,平均病程为 13.8 (5.9) 年。患者曾暴露于DMARDs 9.5 (5.6) 年,这些患者中有 90% 以前接受过生物制剂。一半的妊娠发生在DMARD暴露期间,大部分使用依那西普。未观察到DMARD暴露和未暴露妊娠之间的妊娠结局存在显著差异。与预期的背景率相比,自然流产 (13.1%) 和先天性异常 (3.6%) 率并不提示风险增加。然而,早产 (12.3%) 和剖腹产 (37.7%) 的比率略高于德国分娩人群。女性患者的疾病活动性在妊娠期间保持相对稳定,每三个月的平均cJADAS-10 评分分别为 5.3 、 7.1 和 5.6。 结论: 年轻JIA患者在接受DMARDs治疗的同时,往往会怀孕或成为儿童的父亲。数据表明主要不良妊娠结局的风险没有增加。

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作者列表:["Beltai A","Barnetche T","Daien C","Lukas C","Gaujoux-Viala C","Combe B","Morel J"]

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影响因子:4.13
发表时间:2020-01-01
DOI:10.1002/acr.23824
作者列表:["Chen SK","Liao KP","Liu J","Kim SC"]

METHODS:OBJECTIVE:We aimed to evaluate the comparative risk of hospitalized infection among patients with rheumatoid arthritis (RA) who initiated abatacept versus a tumor necrosis factor inhibitor (TNFi). METHODS:Using claims data from Truven MarketScan database (2006-2015), we identified patients with RA ages ≥18 years with ≥2 RA diagnoses who initiated treatment with abatacept or a TNFi. The primary outcome was a composite end point of any hospitalized infection. Secondary outcomes included bacterial infection, herpes zoster, and infections affecting different organ systems. We performed 1:1 propensity score (PS) matching between the groups in order to control for baseline confounders. We estimated incidence rates (IRs) and hazard ratios (HRs) with 95% confidence intervals (95% CIs) for hospitalized infection. RESULTS:We identified 11,248 PS-matched pairs of patients who initiated treatment with abatacept and TNFi with a median age of 56 years (83% were women). The IR per 1,000 person-years for any hospitalized infection was 37 among patients who initiated treatment with abatacept and 47 in those who initiated treatment with TNFi. The HR for the risk of any hospitalized infection associated with abatacept versus TNFi was 0.78 (95% CI 0.64-0.95) and remained lower when compared to infliximab (HR 0.63 [95% CI 0.47-0.85]), while no significant difference was seen when compared to adalimumab and etanercept. The risk of secondary outcomes was lower for abatacept for pulmonary infections, and similar to TNFi for the remaining outcomes. CONCLUSION:In this large cohort of patients with RA who initiated treatment with abatacept or TNFi as a first- or second-line biologic agent, we found a lower risk of hospitalized infection after initiating abatacept versus TNFi, which was driven mostly by infliximab.

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影响因子:4.13
发表时间:2020-01-01
DOI:10.1002/acr.23827
作者列表:["Lee RR","Rashid A","Thomson W","Cordingley L"]

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