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Molecular findings in maxillofacial bone tumours and its diagnostic value.

颌面部骨肿瘤的分子表现及其诊断价值。

  • 影响因子:2.52
  • DOI:10.1007/s00428-019-02726-2
  • 作者列表:"Cleven AHG","Schreuder WH","Groen E","Kroon HM","Baumhoer D
  • 发表时间:2020-01-01
Abstract

:According to the WHO, mesenchymal tumours of the maxillofacial bones are subdivided in benign and malignant maxillofacial bone and cartilage tumours, fibro-osseous and osteochondromatous lesions as well as giant cell lesions and bone cysts. The histology always needs to be evaluated considering also the clinical and radiological context which remains an important cornerstone in the classification of these lesions. Nevertheless, the diagnosis of maxillofacial bone tumours is often challenging for radiologists as well as pathologists, while an accurate diagnosis is essential for adequate clinical decision-making. The integration of new molecular markers in a multidisciplinary diagnostic approach may not only increase the diagnostic accuracy but potentially also identify new druggable targets for precision medicine. The current review provides an overview of the clinicopathological and molecular findings in maxillofacial bone tumours and discusses the diagnostic value of these genetic aberrations.

摘要

根据世界卫生组织,颌面部间叶性肿瘤分为良性和恶性颌面部骨和软骨肿瘤、纤维骨和骨软骨瘤病变以及巨细胞病变和骨囊肿。组织学总是需要考虑到临床和放射学背景进行评估,这仍然是这些病变分类的重要基石。尽管如此,对于放射科医生和病理学家来说,颌面部骨肿瘤的诊断往往是具有挑战性的,而准确的诊断对于充分的临床决策至关重要。将新的分子标志物整合到多学科诊断方法中,不仅可能增加诊断准确性,还可能为精准医疗确定新的药物靶点。本综述概述了颌面部骨肿瘤的临床病理和分子表现,并讨论了这些遗传畸变的诊断价值。

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作者列表:["Denadai R","Seo HJ","Lo LJ"]

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影响因子:0.73
发表时间:2020-01-01
DOI:10.1097/SCS.0000000000005693
作者列表:["Jahanbin A","Eslami N","Torkamanzadeh N"]

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颌部疾病方向

颌部的疾病,包括颌畸形、颌骨囊肿、颌骨肿瘤等疾病。

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