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Effect of high molecular weight hyaluronic acid in treatment of osteoarthritic temporomandibular joints of rats.

高分子量透明质酸对大鼠颞下颌骨关节病的治疗作用

  • 影响因子:1.98
  • DOI:10.1016/j.archoralbio.2019.104618
  • 作者列表:"Tolba YM","Omar SS","Nagui DA","Nawwar MA
  • 发表时间:2020-02-01
Abstract

OBJECTIVE:The aim of this study was to determine the histological and biochemical effects of high molecular weight hyaluronic acid on experimentally induced osteoarthritic changes in male rat temporomandibular joint (TMJ). DESIGN:In this in-vivo study, 36 male albino rats were divided into 3 groups; control non-injected, disease and treatment group. Osteoarthritis was induced using a single intra-articular injection of Complete Freund's adjuvant (CFA) (50 μl). High molecular weight hyaluronic acid (HMWHA) was injected intra-articularly once a week, for a total of 3 injections. TMJ tissue samples were dissected from control, disease and treatment groups for biochemical analysis using ELISA test to detect the levels of matrix metalloproteinase-3 (MMP-3) on day 28. Histological examination was done using Hematoxylin &eosin, Mallory's trichrome and Alcian blue stains. Data was analyzed using Kruskal-Wallis test followed by Dunn-Sidek method, with a 5 % significance level. RESULTS:Treatment group showed regaining of the normal histological features of the TMJ and decreased levels of MMP-3 when compared to disease group. CONCLUSIONS:These findings may suggest that HMWHA plays a role in the management of CFA-induced osteoarthritic cartilage lesions.

摘要

目的: 研究高分子量透明质酸对实验性大鼠颞下颌关节 (TMJ) 骨性关节炎的组织学和生化影响。 设计: 在体内研究中,36 只雄性白化大鼠分为 3 组; 对照组非注射,疾病和治疗组。使用单次关节腔内注射完全弗氏佐剂 (CFA) (50 μ l) 诱导骨关节炎。关节内注射高分子量透明质酸 (HMWHA),每周 1 次,共注射 3 次。采用ELISA法检测第 28 天对照组、疾病组和治疗组TMJ组织标本的基质metalloproteinase-3 (MMP-3) 水平。使用苏木精和伊红、Mallory三色染色和Alcian蓝色染色进行组织学检查。使用Kruskal-Wallis检验分析数据,然后使用Dunn-Sidek方法,显著性水平为 5%。 结果: 与疾病组相比,治疗组TMJ恢复了正常组织学特征,MMP-3 水平降低。 结论: 这些发现可能表明HMWHA在CFA诱导的骨关节炎软骨病变的治疗中发挥作用。

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发表时间:2020-01-01
DOI:10.1016/j.bjps.2019.05.033
作者列表:["Denadai R","Seo HJ","Lo LJ"]

METHODS:BACKGROUND:The anterior oronasal fistulae neighboring the alveolar cleft could persist or reappear after the alveolar reconstruction with cancellous bone grafting. The persistent symptomatic anterior oronasal fistulae need to be repaired, but surgery remains a challenge in cleft care. Surprisingly, this issue has rarely been reported in the literature. The purpose of this long-term study was to report a single surgeon experience with a therapeutic protocol for persistent symptomatic anterior oronasal fistula repair. METHODS:This is a retrospective study of consecutive patients with Veau type III and IV clefts and persistent symptomatic anterior oronasal fistulae managed according to a therapeutic protocol from 1997 to 2018. Depending on fistula size, patients were treated with local flaps associated with an interpositional graft or two-stage tongue flaps (small/medium or large fistulae, respectively). The surgical outcomes were classified as "good" (complete fistula closure with no symptoms), "fair" (asymptomatic narrow fistula remained), or "poor" (failure with persistent symptoms). RESULTS:Forty-four patients with persistent symptomatic anterior oronasal fistulae were reconstructed with local flaps associated with interpositional fascia or dermal fat grafting (52.3%) or two-stage tongue flaps (47.7%). Most of patients (93.2%) presented "good" outcomes, ranging from 87% to 100% (local and tongue flaps, respectively). Three (6.8%) patients presented symptomatic residual fistula ("poor" outcomes). CONCLUSIONS:For the repair of persistent symptomatic anterior oronasal fistulae, this therapeutic protocol provided satisfactory outcome with low fistula recurrence rate.

翻译标题与摘要 下载文献
影响因子:2.49
发表时间:2020-03-01
DOI:10.1136/archdischild-2019-316804
作者列表:["Cleary B","Loane M","Addor MC","Barisic I","de Walle HEK","Matias Dias C","Gatt M","Klungsoyr K","McDonnell B","Neville A","Pierini A","Rissmann A","Tucker DF","Zurriaga O","Dolk H"]

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影响因子:0.73
发表时间:2020-01-01
DOI:10.1097/SCS.0000000000005693
作者列表:["Jahanbin A","Eslami N","Torkamanzadeh N"]

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颌部疾病方向

颌部的疾病,包括颌畸形、颌骨囊肿、颌骨肿瘤等疾病。

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