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Longitudinal study of the development of obstruent correctness from ages 3 to 5 years in 108 Danish children with unilateral cleft lip and palate: a sub-study within a multicentre randomized controlled trial.

108 例丹麦单侧唇腭裂患儿 3 ~ 5 岁obstruent正确性发展的纵向研究: 一项多中心随机对照试验内的子研究。

  • 影响因子:1.96
  • DOI:10.1111/1460-6984.12508
  • 作者列表:"Jørgensen LD","Willadsen E
  • 发表时间:2020-01-01
Abstract

BACKGROUND:Speech-sound development in preschoolers with unilateral cleft lip and palate (UCLP) as a group is delayed/disordered, and obstruents comprise the most vulnerable sound class. AIMS:To evaluate the development of obstruent correctness (PCC-obs) and error types (cleft speech characteristics (CSCs) and developmental speech characteristics (DSCs)) from ages 3-5 and to investigate possible predictors (error types, velopharyngeal dysfunction (VPD) and gender) of PCC-obs at age 5 in two groups of children with UCLP. METHODS & PROCEDURES:Subgroup analysis was conducted within a multicentre randomized controlled trial (RCT) of primary surgery (Scandcleft Project). A total of 125 Danish children with UCLP received lip and soft palate repair around 4 months of age and early hard palate closure at 12 months (EHPC group) or late hard palate closure at 36 months (LHPC group). Audio and video recordings of a naming test were available for 108 children at ages 3 and 5, and recordings were transcribed phonetically by blinded raters. OUTCOMES & RESULTS:PCC-obs scores increased significantly from ages 3-5 in both groups, but with small effect sizes in the EHPC group that had higher scores at age 3 than the LHPC group. DSCs decreased in both groups whereas CSCs only decreased in the LHPC group that had more CSCs at age 3 than the EHPC group. The frequency of CSCs at age 3 was a significant predictor of PCC-obs scores at age 5 in both groups. DSCs significantly improved the logistic regression model in the EHPC group, whereas VPD and gender did not significantly improve the model in either group. CONCLUSIONS & IMPLICATIONS:Although PCC-obs developed significantly from ages 3 to 5, children with UCLP as a group did not catch up to typically developing Danish children at age 5. Furthermore, the LHPC group at age 5 did not reach the 3-year level of the EHPC group, which means that delaying hard palate closure until age 3 is detrimental to obstruent development. Both CSCs and DSCs at age 3 were important predictors of PCC-obs at age 5 and should be considered when determining need for intervention.

摘要

背景: 单侧唇腭裂 (UCLP) 为群体的学龄前儿童语音发育延迟/紊乱,obstruct患者构成最脆弱的声音类别。 目的: 评估obstruent正确性 (PCC-obs) 和错误类型 (分裂语音特征 (CSCs) 和发育语音特征 (DSCs)) 的发展从 3-5 岁开始,调查两组UCLP患儿 5 岁时PCC-obs的可能预测因素 (错误类型、腭咽闭合功能障碍 (VPD) 和性别)。 方法和步骤: 在一项初次手术的多中心随机对照试验 (RCT) 中进行亚组分析。共有 12 5 名患有UCLP的丹麦儿童在 4 个月左右接受了唇和软腭修复,12 个月时接受了早期硬腭关闭 (EHPC组) 或 36 个月时硬腭关闭晚期 (LHPC组)。录音和录像命名test可供 108 名儿童年龄 3 和 5,录音转录语音通过盲评分员. 结局和结果: 两组PCC-obs评分从 3-5 岁开始显著增加,但EHPC组的效应量较小,3 岁时的评分高于LHPC组。两组DSCs均降低,而仅在 3 岁时CSCs多于EHPC组的LHPC组CSCs降低。3 岁时CSCs的频率是两组 5 岁时PCC-obs评分的显著预测因子。DSCs显著改善了EHPC组的logistic回归模型,而VPD和性别未显著改善两组的模型。 结论和意义: 尽管PCC-obs在 3 ~ 5 岁显著发展,但UCLP患儿在 5 岁时没有赶上典型发育中的丹麦儿童。此外,5 岁时的LHPC组没有达到EHPC组的 3 年水平,这意味着延迟硬腭关闭到 3 岁对obstruent发育是有害的。3 岁时的CSCs和DSCs都是 5 岁时PCC-obs的重要预测因子,在确定干预需求时应予以考虑。

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METHODS::Impairments in social cognition have been frequently described in 22q11.2 deletion syndrome (22q11.2DS) and are thought to be a hallmark of difficulties in social interactions. The present study addresses aspects that are critical for everyday social cognitive functioning but have received little attention so far. Sixteen children with 22q11.2DS and 22 controls completed 1 task of facial expression recognition, 1 task of attribution of facial expressions to faceless characters involved in visually presented social interactions, and 1 task of attribution of facial expressions to characters involved in aurally presented dialogues. All three tasks have in common to involve processing of emotions. All participants also completed two tasks of attention and two tasks of visual spatial perception, and their parents completed some scales regarding behavioural problems of their children. Patients performed worse than controls in all three tasks of emotion processing, and even worse in the second and third tasks. However, they performed above chance level in all three tasks, and the results were independent of IQ, age and gender. The analysis of error patterns suggests that patients tend to coarsely categorize situations as either attractive or repulsive and also that they have difficulties in differentiating emotions that are associated with threats. An isolated association between the tasks of emotion and behaviour was found, showing that the more frequently patients with 22q11.2DS perceive happiness where there is not, the less they exhibit aggressive behaviour.

影响因子:0.95
发表时间:2020-02-01
DOI:10.1007/s11845-019-02039-y
作者列表:["Sheridan GA","Nagle M","Howells C","Gallagher O","Kiely PJ","O'Toole P","Kelly PM","Moore DP"]

METHODS:BACKGROUND:We describe the first radiographic clinic in the literature for DDH and how this novel clinic can significantly improve the efficiency and cost-effectiveness of service in a tertiary referral centre. AIMS:A radiographic clinic for the management of developmental dysplasia of the hip was introduced in 2017 in our institution. We performed a detailed cost analysis to assess the economic savings made with the introduction of this new clinic. We assessed the efficiency of the service by identifying how many unnecessary outpatient visits were prevented. We also assessed the difference in times from referral to review between the two clinics. METHODS:Analysis of the clinic activity in 2017 was possible as all data was collected prospectively by the DDH CNS and stored in our database. Cost analysis was performed, and the savings made per patient along with the financial benefit to our institution was recorded. RESULTS:The new radiographic clinic reduced the cost of reviewing one patient by €162.51 per patient. There was a 73% discharge rate from the clinic which prevented 251 unnecessary patient visits to the outpatient department over the course of the year. There was a significant 11-day reduction in waiting times between referral and review when comparing the radiographic to the conventional clinic (p < 0.05). CONCLUSIONS:A radiographic clinic for the management of developmental dysplasia of the hip has a significant effect on the efficiency and overall cost-effectiveness of service provision in a tertiary referral centre.

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影响因子:2.43
发表时间:2020-01-15
DOI:10.5435/JAAOS-D-16-00918
作者列表:["Grigoryan G","Korcek L","Eidelman M","Paley D","Nelson S"]

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