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Efficacy of Anti-PD1/PD-L1 Therapy (IO) in KRAS Mutant Non-small Cell Lung Cancer Patients: A Retrospective Analysis.

KRAS突变型非小细胞肺癌患者Anti-PD1/PD-L1 治疗 (IO) 的疗效: 回顾性分析。

  • 影响因子:1.90
  • DOI:10.21873/anticanres.13970
  • 作者列表:"Gianoncelli L","Spitaleri G","Passaro A","Radice D","Fumagalli C","Del Signore E","Stati V","Catania CM","Guerini-Rocco E","Barberis M","DE Marinis F
  • 发表时间:2020-01-01
Abstract

BACKGROUND/AIM:The role of anti-PD1/PD-L1 therapy (IO) in NSCLC harboring driver mutations is questionable. This study aimed to examine the efficacy of IO in patients with non-small cell lung cancer (NSCLC) with a KRAS mutation (KRAS+). PATIENTS AND METHODS:We retrospectively identified NSCLC patients harboring KRAS mutation treated with IO in our Institution. We analyzed the results in comparison to non-KRAS patients. RESULTS:Among 328 consecutive KRAS+ NSCLC patients, 43 (13.1%) received IO in our Institution. In parallel 117 non-KRAS NSCLC patients treated with IO were selected for comparison. The baseline characteristics were similar between the two groups. No significant difference was observed between KRAS+ and non-KRAS patients in terms of mPFS (4.6 vs. 3.3 months, p=0.58) or OS (8.1 vs. 13.0 months, p=0.38). CONCLUSION:KRAS mutations seem to be irrelevant for selecting patients for IO that could be therefore considered an effective therapy for NSCLC patients, independently of KRAS status.

摘要

背景/目的: anti-PD1/PD-L1 治疗 (IO) 在携带驱动突变的NSCLC中的作用值得怀疑。本研究旨在检测IO在具有KRAS突变 (KRAS +) 的非小细胞肺癌 (NSCLC) 患者中的疗效。 患者和方法: 我们回顾性鉴定了在我们机构中使用IO治疗的携带KRAS突变的NSCLC患者。我们分析了与非KRAS患者比较的结果。 结果: 在 328 例连续KRAS + NSCLC患者中,43 例 (13.1%) 在我们机构接受IO。平行地,选择 117 例用IO治疗的非KRAS NSCLC患者进行比较。两组的基线特征相似。KRAS + 和非KRAS患者在mPFS方面没有观察到显著差异 (4.6 vs. 3.3 个月,p = 0.58) 或OS (8.1 vs. 13.0 个月,p = 0.38)。 结论: KRAS突变似乎与选择IO患者无关,因此可被认为是NSCLC患者的有效治疗,与KRAS状态无关。

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肺肿瘤方向

肺肿瘤,又叫支气管肺癌,是常见的恶性肿瘤之一。肺肿瘤的治疗为包括手术、中药、放疗、化疗及免疫等多学科的综合治疗。

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