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Two cases of granuloma mimicking local recurrence after pulmonary segmentectomy.

肺段切除术后肉芽肿类似局部复发 2 例。

  • 影响因子:1.39
  • DOI:10.1186/s13019-020-1055-z
  • 作者列表:"Okazaki M","Sano Y","Mori Y","Sakao N","Yukumi S","Shigematsu H","Izutani H
  • 发表时间:2020-01-08
Abstract

BACKGROUND:Fluorodeoxyglucose (FDG)-positron emission tomography (PET)/CT is the most sensitive non-invasive imaging method for the detection of tumor metastasis and recurrence, but sometimes reveals false-positive results. Herein, we report two cases of false-positive results on PET/CT scans along with elevated serum carcinoembryonic antigen (CEA) levels, mimicking local recurrence after pulmonary segmentectomy. CASE PRESENTATION:Case 1; A 75-year-old woman underwent thoracoscopic left basal segmentectomy for primary lung cancer. Follow-up at 6 months after the surgery revealed serum CEA level elevation and chest CT showed a nodule measuring 25 × 22 mm in the residual left lower lobe. PET/CT revealed FDG uptake in the nodule diagnosed as local recurrence of lung cancer, and the patient underwent partial resection of the nodule. Microscopic examination of the resected specimen revealed granuloma caused by polyglycolic acid (PGA) sheet. Case 2; A 58-year-old man underwent VATS right S1 segmentectomy for lung metastasis from rectal carcinoma. Serum CEA levels gradually increased after surgery, and PET/CT revealed FDG uptake in the stump diagnosed as local recurrence of the lung metastasis. The patient underwent completion lobectomy 6 months after the segmentectomy, and the pathology of the resected specimen revealed an inflammatory granuloma caused by PGA suture. CONCLUSIONS:Although suture and stapler granulomas have been reported, granuloma caused by PGA sheets has never been reported. Postoperative recurrence of lung cancer should be diagnosed with not only PET/CT scans and serum tumor markers but also pathological findings, to avoid unnecessary treatment such as chemotherapy, radiation, and difficult reoperation.

摘要

背景: 氟代脱氧葡萄糖 (FDG)-正电子发射断层显像 (PET)/CT是目前检测肿瘤转移和复发最敏感的无创成像方法,但有时会显示假阳性结果。在此,我们报告了两例PET/ct扫描假阳性结果以及血清癌胚抗原 (CEA) 水平升高,模拟肺段切除术后局部复发。 病例报告: 病例 1; 一名 75 岁女性因原发性肺癌行胸腔镜下左基底段切除术。术后 6 个月随访发现血清CEA水平升高,胸部CT显示左下叶残留结节 25 × 22mm。PET/CT显示结节FDG摄取,诊断为肺癌局部复发,患者行结节部分切除术。切除标本的显微镜检查显示由聚乙醇酸 (PGA) 片引起的肉芽肿。病例 2: 一名 58 岁男性因直肠癌肺转移行VATS右S1 段切除术。术后血清CEA水平逐渐升高,PET/CT提示残端FDG摄取,诊断为肺转移局部复发。患者在肺段切除术后 6 个月完成肺叶切除术,切除标本的病理显示为PGA缝线引起的炎性肉芽肿。 结论: 尽管缝合线和吻合器肉芽肿已有报道,但从未报道过由PGA片引起的肉芽肿。肺癌术后复发的诊断除PET/ct扫描和血清肿瘤标志物外,还应结合病理检查结果,避免化疗、放疗等不必要的治疗,避免再次手术困难。

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影响因子:6.93
发表时间:2020-01-15
DOI:10.1002/ijc.32532
作者列表:["Hata A","Nakajima T","Matsusaka K","Fukuyo M","Morimoto J","Yamamoto T","Sakairi Y","Rahmutulla B","Ota S","Wada H","Suzuki H","Matsubara H","Yoshino I","Kaneda A"]

METHODS::Patients with idiopathic pulmonary fibrosis (IPF) have higher risk of developing lung cancer, for example, squamous cell carcinoma (SCC), and show poor prognosis, while the molecular basis has not been fully investigated. Here we conducted DNA methylome analysis of lung SCC using 20 SCC samples with/without IPF, and noncancerous lung tissue samples from smokers/nonsmokers, using Infinium HumanMethylation 450K array. SCC was clustered into low- and high-methylation epigenotypes by hierarchical clustering analysis. Genes hypermethylated in SCC significantly included genes targeted by polycomb repressive complex in embryonic stem cells, and genes associated with Gene Ontology terms, for example, "transcription" and "cell adhesion," while genes hypermethylated specifically in high-methylation subgroup significantly included genes associated with "negative regulation of growth." Low-methylation subgroup significantly correlated with IPF (78%, vs. 17% in high-methylation subgroup, p = 0.04), and the correlation was validated by additional Infinium analysis of SCC samples (n = 44 in total), and data from The Cancer Genome Atlas (n = 390). The correlation between low-methylation subgroup and IPF was further validated by quantitative methylation analysis of marker genes commonly hypermethylated in SCC (HOXA2, HOXA9 and PCDHGB6), and markers specifically hypermethylated in high-methylation subgroup (DLEC1, CFTR, MT1M, CRIP3 and ALDH7A1) in 77 SCC cases using pyrosequencing (p = 0.003). Furthermore, low-methylation epigenotype significantly correlated with poorer prognosis among all SCC patients, or among patients without IPF. Multivariate analysis showed that low-methylation epigenotype is an independent predictor of poor prognosis. These may suggest that lung SCC could be stratified into molecular subtypes with distinct prognosis, and low-methylation lung SCC that significantly correlates with IPF shows unfavorable outcome.

翻译标题与摘要 下载文献
影响因子:6.93
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DOI:10.1002/ijc.32530
作者列表:["Zhang L","Yang Y","Chai L","Bu H","Yang Y","Huang H","Ran J","Zhu Y","Li L","Chen F","Li W"]

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肺肿瘤方向

肺肿瘤,又叫支气管肺癌,是常见的恶性肿瘤之一。肺肿瘤的治疗为包括手术、中药、放疗、化疗及免疫等多学科的综合治疗。

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