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Clinical impact of post-induction resolution of pulmonary lesions in metastatic Ewing sarcoma.

转移性尤文肉瘤诱导后肺部病灶消退的临床影响。

  • 影响因子:2.28
  • DOI:10.1002/pbc.28150
  • 作者列表:"Halalsheh H","Kaste SC","Krasin MJ","Sykes A","Sahr N","Spunt SL","Federico SM","Bishop MW
  • 发表时间:2020-04-01
Abstract

BACKGROUND:Patients with metastatic Ewing sarcoma experience poor outcomes despite intensive systemic and local therapy. Early chemotherapy response of pulmonary metastases has been associated with prognosis in other pediatric malignancies. We reviewed the outcomes of patients with Ewing sarcoma and pulmonary metastases treated at our institution based on therapy received and early pulmonary response. MATERIALS AND METHODS:We retrospectively reviewed patients with newly diagnosed Ewing sarcoma and pulmonary metastases at St. Jude Children's Research Hospital between 1979 and 2015. Data obtained included demographic and treatment characteristics including chemotherapy, local control measures, whole lung irradiation (WLI) administration, autologous stem cell transplantation, and outcomes. Patients were evaluated for radiographic post-induction pulmonary complete response (CR). We estimated event-free survival (EFS) and overall survival (OS) and used Cox proportional hazards regression to examine the effects of clinical and treatment factors on outcomes. RESULTS:Fifty-four patients (median age, 12.9 years) were evaluated. Post-induction pulmonary CR was observed in 33 (61%) patients. WLI was delivered to 16 patients (4/33 with pulmonary CR and 12/21 with non-CR). At median 3.6 years follow-up, five-year EFS and OS were 30.8% ± 6.4% and 49.6% ± 7.1%, respectively. Post-induction pulmonary CR was associated with prolonged EFS (P < 0.001) but not improved OS (P = 0.065). Post-induction pulmonary CR was associated with a lower incidence of lung failure (P = 0.031). CONCLUSIONS:Post-induction pulmonary CR is associated with improved EFS in patients with Ewing sarcoma who present with pulmonary metastases.

摘要

背景: 转移性尤文肉瘤患者尽管进行了强化的全身和局部治疗,但预后较差。肺转移的早期化疗反应与其他儿童恶性肿瘤的预后相关。我们回顾了在我们机构治疗的尤文肉瘤和肺转移患者的结果,这些患者基于接受的治疗和早期肺部反应。 材料和方法: 我们回顾性分析了 1979 年至 2015 年间圣裘德儿童研究医院新诊断的尤文肉瘤和肺转移患者。获得的数据包括人口统计学和治疗特征,包括化疗,局部控制措施,全肺照射 (WLI) 给药,自体干细胞移植和结果。评估患者的诱导后肺部完全反应 (CR)。我们估计无事件生存期 (EFS) 和总生存期 (OS),并使用Cox比例风险回归来检查临床和治疗因素对结局的影响。 结果: 54 例患者 (中位年龄,12.9 岁) 被评估。在 33 例 (61%) 患者中观察到诱导后肺CR。将WLI递送至 16 例患者 (4/33 为肺CR,12/21 为非CR)。中位随访 3.6 年,5 年EFS和OS分别为 30.8% ± 6.4% 和 49.6% ± 7.1%。诱导后肺CR与延长的EFS相关 (P <0.001),但不改善OS (P = 0.065)。诱导后肺CR与较低的肺衰竭发生率相关 (P = 0.031)。 结论: 诱导后肺CR与Ewing肉瘤肺转移患者EFS改善有关。

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影响因子:6.93
发表时间:2020-01-15
DOI:10.1002/ijc.32532
作者列表:["Hata A","Nakajima T","Matsusaka K","Fukuyo M","Morimoto J","Yamamoto T","Sakairi Y","Rahmutulla B","Ota S","Wada H","Suzuki H","Matsubara H","Yoshino I","Kaneda A"]

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翻译标题与摘要 下载文献
影响因子:6.93
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DOI:10.1002/ijc.32530
作者列表:["Zhang L","Yang Y","Chai L","Bu H","Yang Y","Huang H","Ran J","Zhu Y","Li L","Chen F","Li W"]

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肺肿瘤方向

肺肿瘤,又叫支气管肺癌,是常见的恶性肿瘤之一。肺肿瘤的治疗为包括手术、中药、放疗、化疗及免疫等多学科的综合治疗。

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