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Comprehensive T cell repertoire characterization of non-small cell lung cancer.

非小细胞肺癌的综合T细胞谱系表征。

  • 影响因子:12.19
  • DOI:10.1038/s41467-019-14273-0
  • 作者列表:"Reuben A","Zhang J","Chiou SH","Gittelman RM","Li J","Lee WC","Fujimoto J","Behrens C","Liu X","Wang F","Quek K","Wang C","Kheradmand F","Chen R","Chow CW","Lin H","Bernatchez C","Jalali A","Hu X","Wu CJ","Eterovic AK","Parra ER","Yusko E","Emerson R","Benzeno S","Vignali M","Wu X","Ye Y","Little LD","Gumbs C","Mao X","Song X","Tippen S","Thornton RL","Cascone T","Snyder A","Wargo JA","Herbst R","Swisher S","Kadara H","Moran C","Kalhor N","Zhang J","Scheet P","Vaporciyan AA","Sepesi B","Gibbons DL","Robins H","Hwu P","Heymach JV","Sharma P","Allison JP","Baladandayuthapani V","Lee JJ","Davis MM","Wistuba II","Futreal PA","Zhang J
  • 发表时间:2020-01-30
Abstract

:Immunotherapy targeting T cells is increasingly utilized to treat solid tumors including non-small cell lung cancer (NSCLC). This requires a better understanding of the T cells in the lungs of patients with NSCLC. Here, we report T cell repertoire analysis in a cohort of 236 early-stage NSCLC patients. T cell repertoire attributes are associated with clinicopathologic features, mutational and immune landscape. A considerable proportion of the most prevalent T cells in tumors are also prevalent in the uninvolved tumor-adjacent lungs and appear specific to shared background mutations or viral infections. Patients with higher T cell repertoire homology between the tumor and uninvolved tumor-adjacent lung, suggesting a less tumor-focused T cell response, exhibit inferior survival. These findings indicate that a concise understanding of antigens and T cells in NSCLC is needed to improve therapeutic efficacy and reduce toxicity with immunotherapy, particularly adoptive T cell therapy.

摘要

靶向T细胞的免疫疗法越来越多地用于治疗实体瘤,包括非小细胞肺癌 (NSCLC)。这需要更好地了解NSCLC患者肺部的T细胞。在这里,我们报告了 236 例早期NSCLC患者的T细胞库分析。T细胞库属性与临床病理特征、突变和免疫景观相关。肿瘤中最普遍的T细胞的相当大的比例也普遍存在于未涉及的邻近肿瘤的肺中,并且似乎对共同的背景突变或病毒感染是特异性的。肿瘤和未累及的肿瘤邻近肺之间具有较高T细胞库同源性的患者,表明较少的肿瘤聚焦T细胞应答,表现出较差的存活率。这些发现表明,需要对NSCLC中的抗原和T细胞的简明理解,以提高治疗功效并减少免疫疗法,特别是过继性T细胞疗法的毒性。

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影响因子:6.93
发表时间:2020-01-15
DOI:10.1002/ijc.32532
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翻译标题与摘要 下载文献
影响因子:6.93
发表时间:2020-01-01
DOI:10.1002/ijc.32530
作者列表:["Zhang L","Yang Y","Chai L","Bu H","Yang Y","Huang H","Ran J","Zhu Y","Li L","Chen F","Li W"]

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肺肿瘤方向

肺肿瘤,又叫支气管肺癌,是常见的恶性肿瘤之一。肺肿瘤的治疗为包括手术、中药、放疗、化疗及免疫等多学科的综合治疗。

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