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Significance of Quantitative Interferon-gamma Levels in Non-small-cell Lung Cancer Patients' Response to Immune Checkpoint Inhibitors.

定量干扰素-γ 水平在非小细胞肺癌患者对免疫检查点抑制剂反应中的意义。

  • 影响因子:1.90
  • DOI:10.21873/anticanres.14251
  • 作者列表:"Kanai T","Suzuki H","Yoshida H","Matsushita A","Kawasumi H","Samejima Y","Noda Y","Nasu S","Tanaka A","Morishita N","Hashimoto S","Kawahara K","Tamura Y","Okamoto N","Tanaka T","Hirashima T
  • 发表时间:2020-05-01
Abstract

BACKGROUND/AIM:We aimed to study the association between the quantitative interferon-gamma (IFN-γ) levels and clinical outcomes in non-small-cell lung cancer (NSCLC) patients receiving immune checkpoint inhibitors (ICIs). PATIENTS AND METHODS:Sample collection for IFN-γ release assay (IGRA) was performed within 14 days before treatment (T1), on day 22±7 (T3), and on day 43±7 (T4). The stored specimens over 10 IU/ml in IGRA were re-examined using the dilution method (with saline as the dilution medium). The patients were classified into Lower and Higher groups by 7.06 IU/ml as a cut-off of IFN-γ levels at T1. RESULTS:Median progression-free survival in the Higher group was significantly longer than that in the Lower group. IFN-γ levels in the non-progression disease group were significantly higher than those in the progression disease group. IFN-γ levels at T1 in patients with immune-related adverse events were significantly lower compared to those at T3. CONCLUSION:IFN-γ could be a biomarker for NSCLC patients receiving ICIs.

摘要

背景/目的: 我们旨在研究定量干扰素-γ (IFN-γ) 水平与非小细胞肺癌 (NSCLC) 临床结局之间的关系。接受免疫检查点抑制剂 (ICIs) 的患者。 患者和方法: 在治疗前 14 天 (T1),第 22 ± 7 天 (T3) 进行IFN-γ 释放测定 (IGRA) 的样品收集,和第 43 ± 7 天 (T4)。使用稀释法 (用盐水作为稀释介质) 重新检查在IGRA中超过 10 iu/ml的储存样品。以 7.06 IU/ml作为t1 时IFN-γ 水平的截止值,将患者分为较低和较高的组。 结果: 较高组的中位无进展生存期显著长于较低组。非进展性疾病组IFN-γ 水平显著高于进展性疾病组。与t3 时相比,具有免疫相关不良事件的患者在T1 时的IFN-γ 水平显著较低。 结论: IFN-γ 可能成为接受ICIs治疗的NSCLC患者的生物标志物。

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影响因子:6.93
发表时间:2020-01-15
DOI:10.1002/ijc.32532
作者列表:["Hata A","Nakajima T","Matsusaka K","Fukuyo M","Morimoto J","Yamamoto T","Sakairi Y","Rahmutulla B","Ota S","Wada H","Suzuki H","Matsubara H","Yoshino I","Kaneda A"]

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影响因子:6.93
发表时间:2020-01-01
DOI:10.1002/ijc.32530
作者列表:["Zhang L","Yang Y","Chai L","Bu H","Yang Y","Huang H","Ran J","Zhu Y","Li L","Chen F","Li W"]

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肺肿瘤方向

肺肿瘤,又叫支气管肺癌,是常见的恶性肿瘤之一。肺肿瘤的治疗为包括手术、中药、放疗、化疗及免疫等多学科的综合治疗。

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