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Efficacy of additional dexamethasone administration for the attenuation of paclitaxel-associated acute pain syndrome.

额外地塞米松给药对减轻紫杉醇相关急性疼痛综合征的疗效。

  • 影响因子:2.83
  • DOI:10.1007/s00520-019-04808-y
  • 作者列表:"Saito Y","Kobayashi M","Yamada T","Sakakibara-Konishi J","Shinagawa N","Kinoshita I","Dosaka-Akita H","Iseki K
  • 发表时间:2020-01-01
Abstract

PURPOSE:Paclitaxel-associated acute pain syndrome (P-APS) affects 80% of patients undergoing therapy. Although it has been shown that prednisone administration for 5 days relieves P-APS, detailed results have not been reported thus far. Therefore, in this study, we evaluated the preventive effect of dexamethasone (DEX) administration against P-APS. METHODS:A total of 60 patients who received carboplatin (area under the curve; AUC = 5-6) plus paclitaxel (200 mg/m2) (plus bevacizumab 15 mg/kg, if non-squamous carcinoma of lung) were enrolled. Eight milligrams of DEX was orally administered on days 2 and 3 to the DEX group patients, and the frequency, severity, duration of P-APS, and other adverse effects in the first cycle were retrospectively evaluated and compared to those observed in control group patients, who were not administered DEX on days 2 and 3. RESULTS:No difference in terms of patient characteristics, except for type of cancer, was observed between groups. The results showed that the frequency of all grade P-APS was approximately 70% and there was no difference between groups. Frequency of ≥ G2 P-APS was 40% in the control group and 14% in the DEX group, demonstrating a significant reduction. Duration of P-APS was 5.8 days in the control group and 4.3 days in the DEX group, which tended to become shorter following additional DEX administration, although this was not significant. Adverse effects other than P-APS induced by chemotherapy were similar between the two groups. CONCLUSION:Additional DEX administration is safe and useful for the attenuation of the severity of P-APS.

摘要

目的: 紫杉醇相关的急性疼痛综合征 (p-aps) 影响 80% 接受治疗的患者。尽管已经表明泼尼松给药 5 天缓解了p-aps,但迄今为止还没有详细的结果报道。因此,在本研究中,我们评估了地塞米松 (DEX) 给药对p-aps的预防作用。 方法: 共 60 例接受卡铂 (曲线下面积; Auc   = 5-6) 加紫杉醇 (200 mg/m2) (加贝伐单抗 15 mg/kg,如果非鳞状细胞癌) 入组。DEX组患者在第 2 天和第 3 天口服DEX 8 毫克,p-aps的频率,严重程度,持续时间,回顾性评估第一周期中的其他不良反应,并与在第 2 天和第 3 天未施用DEX的对照组患者中观察到的不良反应进行比较。 结果: 除癌症类型外,两组患者特征无差异。结果显示,所有等级p-aps的频率约为 70%,并且组间没有差异。对照组和DEX组中 ≥ G2 P-APS的频率分别为 40% 和 14%,表明显著降低。P-aps的持续时间在对照组中为 5.8 天,在DEX组中为 4.3 天,其在额外的DEX施用后趋于变短,尽管这并不显著。除化疗诱导的P-APS外,两组的不良反应相似。 结论: 额外的DEX给药对于减轻p-aps的严重程度是安全和有用的。

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影响因子:6.93
发表时间:2020-01-15
DOI:10.1002/ijc.32532
作者列表:["Hata A","Nakajima T","Matsusaka K","Fukuyo M","Morimoto J","Yamamoto T","Sakairi Y","Rahmutulla B","Ota S","Wada H","Suzuki H","Matsubara H","Yoshino I","Kaneda A"]

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影响因子:6.93
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DOI:10.1002/ijc.32530
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