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Geographic Co-Occurrence of Mesothelioma and Ovarian Cancer Incidence.

间皮瘤和卵巢癌发病率的地理共同发生。

  • 影响因子:2.13
  • DOI:10.1089/jwh.2019.7752
  • 作者列表:"Henley SJ","Peipins LA","Rim SH","Larson TC","Miller JW
  • 发表时间:2020-01-01
Abstract

: Background: Asbestos is an established cause of several cancers, including mesothelioma and ovarian cancer. Incidence of mesothelioma, the sentinel asbestos-associated cancer, varies by state, likely reflecting different levels of asbestos exposure. We hypothesized that states with high mesothelioma incidence may also have high ovarian cancer incidence. Materials and Methods: Using data from the Centers for Disease Control and Prevention National Program for Cancer Registries and the National Cancer Institute Surveillance, Epidemiology, and End Results Program, we examined the geographic co-occurrence of mesothelioma and ovarian cancer incidence rates by U.S. state for 2003-2015. Results: By state, mesothelioma incidence ranged from 0.5 to 1.3 cases per 100,000 persons and ovarian cancer incidence ranged from 9 to 12 cases per 100,000 females. When states were grouped by quartile of mesothelioma incidence, the average ovarian cancer incidence rate was 10% higher in states with the highest mesothelioma incidence than in states with the lowest mesothelioma incidence. Ovarian cancer incidence tended to be higher in states with high mesothelioma incidence (Pearson correlation r = 0.54; p < 0.0001). Conclusions: Data from state cancer registries show ovarian cancer incidence was positively correlated with mesothelioma incidence, suggesting asbestos may be a common exposure. The potential for asbestos exposure has declined since the 1970s because fewer products contain asbestos; however, some products, materials, and buildings may still release asbestos and thousands of workers may be exposed. Ensuring that people are protected from exposure to asbestos in their workplaces, homes, schools, and communities may reduce the risk of several cancers.

摘要

: 背景: 石棉是几种癌症的确定原因,包括间皮瘤和卵巢癌。间皮瘤 (前哨石棉相关癌症) 的发病率因州而异,可能反映了不同水平的石棉暴露。我们假设具有高间皮瘤发病率的州也可能具有高卵巢癌发病率。 材料与方法: 使用疾病控制和预防中心国家癌症登记计划和国家癌症研究所监测流行病学学和最终结果计划的数据,我们检查了美国各州 2003-2015 的间皮瘤和卵巢癌发病率的地理共同发生率。 结果: 按州划分,间皮瘤发病率为每 0.5 人中 1.3 至 100,000 例,卵巢癌发病率为每 100,000 人中 9 至 12 例。当按间皮瘤发病率的四分位数分组时,发病率间皮瘤发病率最高的州的平均卵巢癌比间皮瘤发病率最低的州高 10%。在间皮瘤发病率高的州,卵巢癌发病率往往更高 (Pearson相关性r   =   0.54; P  <  0.0001)。 结论: 来自州癌症登记处的数据显示,卵巢癌发病率与间皮瘤发病率呈正相关,提示石棉可能是一种常见的暴露。自 20 世纪 70 年代以来,石棉暴露的可能性已经下降,因为含有石棉的产品较少; 然而,一些产品、材料和建筑物仍可能释放石棉,数千名工人可能会暴露。确保人们在工作场所、家庭、学校和社区免受石棉接触,可能会降低几种癌症的风险。

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影响因子:6.93
发表时间:2020-01-15
DOI:10.1002/ijc.32532
作者列表:["Hata A","Nakajima T","Matsusaka K","Fukuyo M","Morimoto J","Yamamoto T","Sakairi Y","Rahmutulla B","Ota S","Wada H","Suzuki H","Matsubara H","Yoshino I","Kaneda A"]

METHODS::Patients with idiopathic pulmonary fibrosis (IPF) have higher risk of developing lung cancer, for example, squamous cell carcinoma (SCC), and show poor prognosis, while the molecular basis has not been fully investigated. Here we conducted DNA methylome analysis of lung SCC using 20 SCC samples with/without IPF, and noncancerous lung tissue samples from smokers/nonsmokers, using Infinium HumanMethylation 450K array. SCC was clustered into low- and high-methylation epigenotypes by hierarchical clustering analysis. Genes hypermethylated in SCC significantly included genes targeted by polycomb repressive complex in embryonic stem cells, and genes associated with Gene Ontology terms, for example, "transcription" and "cell adhesion," while genes hypermethylated specifically in high-methylation subgroup significantly included genes associated with "negative regulation of growth." Low-methylation subgroup significantly correlated with IPF (78%, vs. 17% in high-methylation subgroup, p = 0.04), and the correlation was validated by additional Infinium analysis of SCC samples (n = 44 in total), and data from The Cancer Genome Atlas (n = 390). The correlation between low-methylation subgroup and IPF was further validated by quantitative methylation analysis of marker genes commonly hypermethylated in SCC (HOXA2, HOXA9 and PCDHGB6), and markers specifically hypermethylated in high-methylation subgroup (DLEC1, CFTR, MT1M, CRIP3 and ALDH7A1) in 77 SCC cases using pyrosequencing (p = 0.003). Furthermore, low-methylation epigenotype significantly correlated with poorer prognosis among all SCC patients, or among patients without IPF. Multivariate analysis showed that low-methylation epigenotype is an independent predictor of poor prognosis. These may suggest that lung SCC could be stratified into molecular subtypes with distinct prognosis, and low-methylation lung SCC that significantly correlates with IPF shows unfavorable outcome.

翻译标题与摘要 下载文献
影响因子:6.93
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DOI:10.1002/ijc.32530
作者列表:["Zhang L","Yang Y","Chai L","Bu H","Yang Y","Huang H","Ran J","Zhu Y","Li L","Chen F","Li W"]

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肺肿瘤,又叫支气管肺癌,是常见的恶性肿瘤之一。肺肿瘤的治疗为包括手术、中药、放疗、化疗及免疫等多学科的综合治疗。

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