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The Composition Alteration of Respiratory Microbiota in Lung Cancer.

肺癌呼吸道菌群的组成变化。

  • 影响因子:0
  • DOI:10.1080/07357907.2020.1732405
  • 作者列表:"Zheng X","Sun X","Liu Q","Huang Y","Yuan Y
  • 发表时间:2020-03-01
Abstract

:Background: Previous studies have reported mixed results regarding the composition of respiratory microbiota in lung cancer patients. Therefore, relying on previously published studies, we sought to estimate the relative proportion of respiratory microbiota between lung cancer cases and controls.Methods: MEDLINE, Embase, The Cochrane Library, and Web of Science online databases were systematically searched from inception up to October 14, 2019, to retrieve relevant studies. The relative abundance of each predominant taxon of respiratory microbiota in lung cancer patients and controls was pooled using the reported outcome data.Results: A total of 8 studies comprising 530 participants were included in the final analysis. The pooled phylum level analysis revealed that Bacteroidetes and Proteobacteria were the most abundant bacterial phyla among all participants, recording 17.5%, 47.5% in lung cancer patients, 28.2%, 39.27% in patients with benign pulmonary diseases and 40.62%, 32.09% in healthy controls, respectively. In addition, Actinobacteria and Firmicutes phyla were abundant in lung cancer cases compared to other groups (14.8%, 17.62% for lung cancer versus 13.04%, 13.16% for benign pulmonary nodules and 12.43%, 12.45% for healthy controls). At genus level, Prevotella was predominant in all the participants, and its proportion was relatively lower in cancer patients (25.74% for lung cancer versus 35.59% and 36.75% for benign pulmonary nodules and healthy controls, respectively). Comparatively, Streptococcus was more abundant in lung cancer cases (9.65% in lung cancer versus 7.98%, 7.26% in benign pulmonary nodules and healthy controls).Conclusions: The respiratory microbiota composition of respiratory microbiota significantly differs between lung cancer patients and healthy individuals, and may be used as potential biomarker of lung cancer. In addition, larger sample size, standardized procedures, dynamic monitoring, metabolomics, and culturomics are needed to confirm these results.

摘要

背景: 先前的研究已经报道了关于肺癌患者呼吸道微生物群组成的混合结果。因此,依靠先前发表的研究,我们试图估计肺癌病例和对照之间呼吸微生物群的相对比例。方法: 系统检索MEDLINE、Embase、The Cochrane Library和Web of Science在线数据库,从开始至 2019 年 10 月 14 日,检索相关研究。使用报告的结局数据汇总肺癌患者和对照中呼吸系统微生物群的每个主要分类群的相对丰度。结果: 最终分析共纳入 8 项研究,包括 530 名参与者。汇集门水平分析发现,拟杆菌和变形菌是所有参与者中最丰富的细菌门,记录 17.5%,47.5% 在肺癌患者中,28.2%,良性肺部疾病患者和健康对照者分别为 39.27% 和 40.62% 、 32.09%。此外,与其他组相比,肺癌病例中放线菌和冷门菌含量丰富 (14.8%,肺癌为 17.62%,肺良性结节为 13.04%,肺良性结节为 13.16%,肺良性结节为 12.43%,12.45% 为健康对照)。在属水平上,Prevotella在所有参与者中占优势,其在癌症患者中的比例相对较低 (肺癌为 25.74%,良性肺结节和健康对照为 35.59% 和 36.75%,分别)。相比之下,链球菌在肺癌病例中更丰富 (肺癌为 9.65%,良性肺结节和健康对照为 7.98%,7.26%)。结论: 肺癌患者与健康人呼吸系统菌群组成存在显著差异,可作为肺癌的潜在生物标志物。此外,还需要更大的样本量、标准化程序、动态监测、代谢组学和培养学来证实这些结果。

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影响因子:6.93
发表时间:2020-01-15
DOI:10.1002/ijc.32532
作者列表:["Hata A","Nakajima T","Matsusaka K","Fukuyo M","Morimoto J","Yamamoto T","Sakairi Y","Rahmutulla B","Ota S","Wada H","Suzuki H","Matsubara H","Yoshino I","Kaneda A"]

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翻译标题与摘要 下载文献
影响因子:6.93
发表时间:2020-01-01
DOI:10.1002/ijc.32530
作者列表:["Zhang L","Yang Y","Chai L","Bu H","Yang Y","Huang H","Ran J","Zhu Y","Li L","Chen F","Li W"]

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肺肿瘤,又叫支气管肺癌,是常见的恶性肿瘤之一。肺肿瘤的治疗为包括手术、中药、放疗、化疗及免疫等多学科的综合治疗。

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