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Rapid glycemic regulation in poorly controlled patients living with diabetes, a new associated factor in the pathophysiology of Charcot's acute neuroarthropathy.

控制不佳的糖尿病患者的快速血糖调节,这是Charcot急性神经性关节病病理生理学中的一个新的相关因素。

  • 影响因子:3.02
  • DOI:10.1371/journal.pone.0233168
  • 作者列表:"Dardari D","Van GH","M'Bemba J","Laborne FX","Bourron O","Davaine JM","Phan F","Foufelle F","Jaisser F","Penfornis A","Hartemann A
  • 发表时间:2020-05-21
Abstract

OBJECTIVE:Aggressive antidiabetic therapy and rapid glycemic control are associated with diabetic neuropathy. Here we investigated if this is also the case for Charcot neuroarthropathy. RESEARCH DESIGN AND METHODS:HbA1c levels and other relevant data were extracted from medical databases of 44 cases of acute Charcot neuroarthropathy. RESULTS:HbA1c levels significantly declined from 8.25% (67mmol/mol) [7.1%-9.4%](54-79mmol/mol), at -6 months (M-6), to 7.40%(54mmol/mol) [6.70%-8.03%] (50-64 mmol/mol) during the six months preceding the diagnosis of Charcot neuroarthropathy (P <0.001). CONCLUSIONS:HbA1c levels significantly declined during the six months preceding the onset of Charcot neuroarthropathy. This decline seems to be a associated factor with the appearance of an active phase of Charcot neuroarthropathy in poorly controlled patients with diabetic sensitive neuropathy.

摘要

目的: 积极的抗糖尿病治疗和快速血糖控制与糖尿病神经病变有关。在这里,我们调查了夏科神经性关节病的情况。 研究设计和方法: 从44例急性Charcot神经关节病的医学数据库中提取HbA1c水平和其他相关数据。 结果: HbA1c水平显著下降,从8.25% (67mmol/mol) [7.1%-9.4%](54-79mmol/mol),在-6个月 (M-6),到7.40%(54mmol/mol) [6.70%-8.03%] (50-64 mmol/mol)。在诊断Charcot神经性关节病之前的6个月内 (P <0.001)。 结论: 在Charcot神经关节病发作前的6个月内,HbA1c水平显著下降。这种下降似乎是糖尿病敏感神经病变控制不佳患者夏科神经性关节病活动期出现的相关因素。

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