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Effect of experimental, morphological and mechanical factors on the murine spinal cord subjected to transverse contusion: A finite element study.

实验、形态学和力学因素对小鼠脊髓横向挫伤的影响: 有限元研究。

  • 影响因子:3.02
  • DOI:10.1371/journal.pone.0232975
  • 作者列表:"Fournely M","Petit Y","Wagnac E","Evin M","Arnoux PJ
  • 发表时间:2020-05-11
Abstract

:Finite element models combined with animal experimental models of spinal cord injury provides the opportunity for investigating the effects of the injury mechanism on the neural tissue deformation and the resulting tissue damage. Thus, we developed a finite element model of the mouse cervical spinal cord in order to investigate the effect of morphological, experimental and mechanical factors on the spinal cord mechanical behavior subjected to transverse contusion. The overall mechanical behavior of the model was validated with experimental data of unilateral cervical contusion in mice. The effects of the spinal cord material properties, diameter and curvature, and of the impactor position and inclination on the strain distribution were investigated in 8 spinal cord anatomical regions of interest for 98 configurations of the model. Pareto analysis revealed that the material properties had a significant effect (p<0.01) for all regions of interest of the spinal cord and was the most influential factor for 7 out of 8 regions. This highlighted the need for comprehensive mechanical characterization of the gray and white matter in order to develop effective models capable of predicting tissue deformation during spinal cord injuries.

摘要

: 有限元模型与脊髓损伤的动物实验模型相结合,为研究损伤机制对神经组织变形和由此产生的组织损伤的影响提供了机会。因此,我们建立了小鼠颈脊髓的有限元模型,以研究形态学、实验和力学因素对横断挫伤后脊髓力学行为的影响。用小鼠单侧颈部挫伤的实验数据验证了模型的整体力学行为。对于模型的98个配置,在8个感兴趣的脊髓解剖区域中研究了脊髓材料特性、直径和曲率以及冲击器位置和倾斜度对应变分布的影响。帕累托分析显示,材料特性对脊髓的所有感兴趣区域具有显著影响 (p<0.01),并且是8个区域中7个区域的最具影响的因素。这强调了需要对灰质和白质进行全面的机械表征,以便开发能够预测脊髓损伤期间组织变形的有效模型。

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影响因子:1.81
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DOI:10.1080/13696998.2019.1646263
作者列表:["Droege M","Sproule D","Arjunji R","Gauthier-Loiselle M","Cloutier M","Dabbous O"]

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脊髓疾病方向

包括脊髓肿瘤、脊髓非肿瘤样病变和脊髓发育异常。脊髓病变可引起脊髓压迫症。脊髓压迫症是由各种性质的病变引起脊髓、脊神经根及其血管受压的一组病症,可导致患者瘫痪等。

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