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Iron deficiency is a possible risk factor causing right heart failure in Tibetan children living in high altitude area.

铁缺乏是高海拔地区藏族儿童右心衰竭的可能危险因素。

  • 影响因子:1.95
  • DOI:10.1097/MD.0000000000021133
  • 作者列表:"Yu J","Yu L","Li Y","Hu F
  • 发表时间:2020-07-17
Abstract

:The aim of the study is to discuss the risk factor of right heart failure (RHF) especially the association of iron deficiency with RHF in Tibetan children who live in high altitude area. In this retrospective study, we collected the data of Tibetan children from January 2011 to December 2018 in our hospital. The patients included in the study had the following data: age, gender, ferritin, echocardiography, hemoglobin, C-reaction protein, and altitude of residence. According to whether RHF was diagnosed, the patients were divided into RHF group and non-RHF group. Totally 133 patients were included with 59 in RHF group and 74 in non-RHF group. In single factor analysis, age (P = .008), altitude of residence (P < .001), ferritin (P < .001), and pulmonary arterial systolic pressure (P < .001) showed significant difference between the 2 groups. Binary logistic regression was performed to further identify the association of the clinical factors with RHF. Higher pulmonary arterial systolic pressure (odds ratio: 29.303, 95% confidence interval: 5.249-163.589, P < .001) and lower ferritin level (odds ratio: 5.849, 95% confidence interval: 1.585-21.593, P = .008) were independent risk factors associated with RHF. In receiver-operating characteristic curve, the optimal cutoff value of ferritin level was 14.6 μg/L with the sensitivity of 81.4% and specificity of 89.2%. As continuous variable, the correlation between ferritin and RHF was not certain (P = .281). Due to the possibility that iron deficiency be a risk factor of RHF in Tibetan children, prevention and treatment of iron deficiency might be a potential way in reducing the incidence of RHF in this high altitude area.

摘要

本研究旨在探讨高海拔地区藏族儿童右心衰竭 (RHF) 的危险因素,尤其是铁缺乏与RHF的关系。本回顾性研究收集2011年1月至2018年12月在我院就诊的藏族儿童资料。纳入研究的患者具有以下数据: 年龄、性别、铁蛋白、超声心动图、血红蛋白、C-反应蛋白和居住海拔高度。根据是否确诊RHF,将患者分为RHF组和非RHF组。共纳入133例患者,其中RHF组59例,非RHF组74例。单因素分析显示,两组间年龄 (p <.008) 、居住海拔 (p <.001) 、铁蛋白 (p <.001) 、肺动脉收缩压 (p <.001) 差异有统计学意义。进行二元逻辑回归以进一步确定临床因素与RHF的相关性。较高的肺动脉收缩压 (比值比: 29.303,95% 可信区间: 5.249-163.589,p <.001) 和较低的铁蛋白水平 (比值比: 5.849,95% 可信区间: 1.585-21.593,p =.008) 是与RHF相关的独立危险因素。在受试者工作特征曲线中,铁蛋白水平的最佳截断值为14.6 μ g/L,灵敏度为81.4%,特异性为89.2%。作为连续变量,铁蛋白与RHF之间的相关性不确定 (p =.281)。由于铁缺乏可能是藏族儿童RHF的危险因素,因此预防和治疗铁缺乏可能是降低该高海拔地区RHF发病率的潜在途径。

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影响因子:2.36
发表时间:2020-01-01
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DOI:10.1080/09537104.2019.1581922
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