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Late pregnancy screening for preeclampsia with a urinary point-of-care test for misfolded proteins.

用错误折叠蛋白的尿点护理试验对先兆子痫进行晚期妊娠筛查。

  • 影响因子:3.02
  • DOI:10.1371/journal.pone.0233214
  • 作者列表:"Li XM","Liu XM","Xu J","Du J","Cuckle H
  • 发表时间:2020-05-20
Abstract

:The aim was to describe and assess a new late pregnancy point-of-care urinary preeclampsia screening test. Urine samples were collected from a consecutive series of 1,532 pregnant women hospitalized at 20-41 weeks gestation in a Chinese single obstetric unit. A simple disposable Congo red based device was newly developed and employed to prospectively test misfolded proteins in pregnant women's urine. A total of 140 preeclampsia cases were clinically diagnosed, 101 severe and 87 pre-term. Detection and false positive rates were similar in the training and validation subsets with combined 74% and 3.0%. The detection rate was 83% in severe, 86% in pre-term, 49% and 50% in mild and term cases (P<0.0001) respectively. In conclusion, a simple point-of-care urinary test for misfolded proteins can be used to screen for preeclampsia in late pregnancy with very high screening performance. To the best of our knowledge, this is the first study to screen for preeclampsia using Congo red based device in Chinese pregnant population.

摘要

: 目的是描述和评估一种新的晚期妊娠定点尿先兆子痫筛查测试。在中国单一产科单位,连续收集1,532名妊娠20-41周住院的孕妇的尿液样本。新开发了一种简单的一次性刚果红装置,用于前瞻性地测试孕妇尿液中错误折叠的蛋白质。临床诊断子痫前期140例,重度101例,早产87例。检测和假阳性率在训练和验证子集中是相似的,组合为74% 和3.0%。重度检出率为83%,早产检出率为86%,轻度和足月检出率分别为49% 和50% (P<0.0001)。总之,一种简单的针对错误折叠蛋白的即时尿液检测可用于筛查妊娠晚期的先兆子痫,具有非常高的筛查性能。据我们所知,这是第一项在中国孕妇人群中使用刚果红装置筛查先兆子痫的研究。

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排尿障碍方向

因为输尿管阻塞等原因,导致排尿不顺畅或者无法排尿的症状。

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