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Prospective Evaluation of PSMA-Targeted 18F-DCFPyL PET/CT in Men with Biochemical Failure After Radical Prostatectomy for Prostate Cancer.

前列腺癌根治术后生化失败男性PSMA靶向18F-DCFPyL PET/CT的前瞻性评价。

  • 影响因子:5.06
  • DOI:10.2967/jnumed.119.226514
  • 作者列表:"Rowe SP","Campbell SP","Mana-Ay M","Szabo Z","Allaf ME","Pienta KJ","Pomper MG","Ross AE","Gorin MA
  • 发表时间:2020-01-01
Abstract

:Our purpose is to provide the results of a prospective study evaluating prostate-specific membrane antigen-targeted 18F-DCFPyL (2-(3-{1-carboxy-5-[(6-18F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid) PET/CT in patients with biochemical failure after radical prostatectomy for prostate cancer (PCa). Methods: Thirty-one patients with postprostatectomy serum prostate-specific antigen (PSA) levels of at least 0.2 ng/mL and negative conventional imaging results were enrolled in this study and imaged with 18F-DCFPyL PET/CT. A consensus central review identified foci of radiotracer uptake consistent with sites of PCa. Descriptive statistics were used. Results: Twenty-one patients (67.7%) had at least 1 finding on 18F-DCFPyL PET/CT consistent with a site of PCa. Imaging was positive in 59.1% of patients with a PSA level of less than 1.0 ng/mL and in 88.9% of patients with a PSA level of more than 1.0 ng/mL. The median SUVmax across all lesions was 11.6 (range, 1.5-57.6). Conclusion: In this prospective study using the prostate-specific membrane antigen-targeted PET agent 18F-DCFPyL, most patients with biochemical failure after radical prostatectomy had foci of suggestive uptake, even at low serum PSA levels.

摘要

: 我们的目的是提供评估前列腺特异性膜抗原靶向18F-DCFPyL (2-(3-{1-羧基-5-[(6-18f-氟-吡啶-3-羰基)-氨基]-戊基}-脲基)-戊二酸) 的前瞻性研究结果前列腺癌根治术后生化失败患者的PET/CT。方法: 31例前列腺切除术后血清前列腺特异性抗原 (PSA) 水平至少为0.2 ng/mL且常规影像学检查结果为阴性的患者纳入本研究,采用18F-DCFPyL PET/CT成像。共识中心审查确定了与PCa部位一致的放射性示踪剂摄取病灶。使用描述性统计。结果: 21例患者 (67.7%) 在18F-DCFPyL PET/CT上至少1次发现与PCa部位一致。59.1% 的患者PSA水平低于1.0 ng/mL时影像学呈阳性,88.9% 的患者PSA水平高于1.0 ng/mL时影像学呈阳性。所有病灶的中位SUVmax为11.6 (范围,1.5-57.6)。结论: 在这项使用前列腺特异性膜抗原靶向PET试剂18F-DCFPyL的前瞻性研究中,大多数前列腺癌根治术后生化失败的患者即使在血清PSA水平低的情况下也有提示摄取病灶。

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影响因子:2.56
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来源期刊:The Journal of urology
DOI:10.1097/JU.0000000000000313
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