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Matched-Pair Comparison of 68Ga-PSMA-11 PET/CT and 18F-PSMA-1007 PET/CT: Frequency of Pitfalls and Detection Efficacy in Biochemical Recurrence After Radical Prostatectomy.

68Ga-PSMA-11 PET/CT和18F-PSMA-1007 PET/CT的配对比较: 前列腺癌根治术后生化复发的陷阱频率和检测功效。

  • 影响因子:5.06
  • DOI:10.2967/jnumed.119.229187
  • 作者列表:"Rauscher I","Krönke M","König M","Gafita A","Maurer T","Horn T","Schiller K","Weber W","Eiber M
  • 发表时间:2020-01-01
Abstract

:18F-labeled prostate-specific membrane antigen (PSMA)-ligand PET has several principal advantages over 68Ga-PSMA-11. The purpose of this retrospective study was to evaluate the frequency of non-tumor-related uptake and the detection efficacy comparing 68Ga-PSMA-11 PET/CT and 18F-PSMA-1007 PET/CT in recurrent prostate cancer (PC) patients. Methods: The study included 102 patients with biochemically recurrent PC after radical prostatectomy undergoing 18F-PSMA-1007 PET/CT imaging. On the basis of various clinical variables, patients with corresponding 68Ga-PSMA-11 PET/CT scans were matched. All PET/CT scans (n = 204) were reviewed by 1 nuclear medicine physician. First, all PET-positive lesions were noted. Then, lesions suspected of being recurrent PC were differentiated from lesions attributed to a benign origin on the basis of known pitfalls and information from CT. For each region, the SUVmax of the lesion with the highest PSMA-ligand uptake was noted. Detection rates were determined, and SUVmax was compared separately for 68Ga-PSMA-11 and 18F-PSMA-1007. Results: In total, 18F-PSMA-1007 PET and 68Ga-PSMA-11 PET revealed 369 and 178 PSMA-ligand-positive lesions, respectively. 18F-PSMA-1007 PET revealed approximately 5 times more lesions attributed to a benign origin than did 68Ga-PSMA-11 PET (245 vs. 52 lesions, respectively). The benign lesions most frequently observed were ganglia, unspecific lymph node, and bone lesions, at a rate of 43%, 31%, and 24% for 18F-PSMA-1007 PET and 29%, 42%, and 27% for 68Ga-PSMA-11 PET, respectively. The SUVmax of lesions attributed to a benign origin was significantly higher (P < 0.0001) for 18F-PSMA-1007 PET. Further, a similar number of lesions was attributed to recurrent PC (124/369 for 18F-PSMA-1007 PET and 126/178 for 68Ga-PSMA-11 PET). Conclusion: The number of lesions with increased PSMA-ligand uptake attributed to a benign origin is considerably higher for 18F-PSMA-1007 PET than for 68Ga-PSMA-11 PET. This finding indicates the need for sophisticated reader training emphasizing known pitfalls and reporting within the clinical context.

摘要

18f-标记的前列腺特异性膜抗原 (PSMA)-配体PET具有超过68Ga-PSMA-11的几个主要优点。本回顾性研究的目的是评估在复发性前列腺癌 (PC) 患者中比较68Ga-PSMA-11 PET/CT和18F-PSMA-1007 PET/CT的非肿瘤相关摄取频率和检测功效。方法: 本研究包括102例接受18F-PSMA-1007 PET/CT成像的前列腺癌根治术后生化复发PC患者。基于各种临床变量,匹配具有相应68Ga-PSMA-11 PET/ct扫描的患者。所有PET/ct扫描 (n = 204) 均由1名核医学医师审查。首先,注意到所有PET阳性病变。然后,根据已知的缺陷和来自CT的信息,将怀疑是复发性PC的病变与归因于良性起源的病变区分开来。对于每个区域,注意到具有最高PSMA-配体摄取的病变的SUVmax。测定检出率,并分别比较68Ga-PSMA-11和18F-PSMA-1007的SUVmax。结果: 18F-PSMA-1007 PET和68Ga-PSMA-11 PET分别显示369和178的PSMA配体阳性病变。18f-psma-1007pet显示归因于良性起源的病变是68ga-psma-11pet的约5倍 (分别为245对52个病变)。最常观察到的良性病变是神经节、非特异性淋巴结和骨病变,18F-PSMA-1007 PET的发生率分别为43% 、31% 和24%,68Ga-PSMA-11 PET的发生率分别为29% 、42% 和27%。对于18f-psma-1007pet,归因于良性起源的病变的SUVmax显著更高 (P <0.0001)。此外,类似数量的损伤归因于复发性PC (18f-psma-1007pet为124/369,68ga-psma-11pet为126/178)。结论: 18F-PSMA-1007 PET导致良性来源的PSMA配体摄取增加的病变数量显著高于68Ga-PSMA-11 PET。这一发现表明需要复杂的读者培训,强调临床背景下的已知陷阱和报告。

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影响因子:2.56
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作者列表:["Renninger M","Fahmy O","Schubert T","Schmid MA","Hassan F","Stenzl A","Gakis G"]

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来源期刊:The Journal of urology
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