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Normotensive hypokalemic primary hyperaldosteronism mimicking clinical features of anorexia nervosa in a young patient: A case report.

正常血压性低钾血症原发性醛固酮增多症模拟年轻患者神经性厌食症的临床特征: 病例报告。

  • 影响因子:1.95
  • DOI:10.1097/MD.0000000000020826
  • 作者列表:"Huang YC","Tsai MH","Fang YW","Tu ML
  • 发表时间:2020-07-17
Abstract

RATIONALE:The typical clinical presentations of patients with primary aldosteronism (PA) include generalized weakness, fatigue, high blood pressure, and potassium deficiency. However, normotensive PA is rare. Therefore, an atypical presentation of normal blood pressure is a challenge for the diagnosis and treatment of PA. PATIENT CONCERNS:A 43-year-old, thin, and tall woman (body mass index, 18.6 kg/m) with generalized weakness for 1 day presented to our emergency department, where hypokalemia was a significant finding. The initial diagnosis was anorexia nervosa with the evidence of renal potassium wasting with low urinary sodium and chloride levels, metabolic alkalosis, normal blood pressure, and low body mass index. However, neither vomiting features nor other specific induced vomiting features were noted. DIAGNOSES:The laboratory examination revealed high plasma aldosterone level, low plasma renin activity, and extremely high aldosterone-to-renin ratio indicating the diagnosis of PA, confirmed via adrenal computed tomography. INTERVENTIONS:Surgical adrenalectomy was performed. Pathological diagnosis was a benign cortical adenoma. OUTCOMES:Patient's serum potassium level and hormonal status became normalized after surgical removal of adrenal adenoma. She fully recovered without any further sequelae. LESSONS:It is too early to rule out PA based on the presence of normal blood pressure in a patient with metabolic alkalosis and renal wasting hypokalemia. Moreover, PA should be considered in a normotensive patient with an unknown hypokalemic etiology to avoid delayed diagnosis and treatment.

摘要

基本原理: 原发性醛固酮增多症 (PA) 患者的典型临床表现包括全身无力乏力高血压和缺钾。然而,正常血压PA是罕见的。因此,正常血压的非典型表现是PA诊断和治疗的挑战。 患者问题: 一名43岁的瘦高女性 (体重指数,18.6 kg/m2),全身无力1天,到我们的急诊科就诊,低钾血症是一个显著的发现。最初的诊断是神经性厌食症,有肾钾消耗的证据,尿钠和氯水平低,代谢性碱中毒,血压正常,体重指数低。然而,没有注意到呕吐特征和其他特定的诱导呕吐特征。 诊断: 实验室检查显示血浆醛固酮水平高,血浆肾素活性低,醛固酮与肾素比值极高,表明通过肾上腺计算机断层扫描确诊为PA。 干预措施: 手术肾上腺切除术。病理诊断为良性皮质腺瘤。 结果: 手术切除肾上腺腺瘤后,患者的血清钾水平和激素状态恢复正常。她完全康复,没有任何进一步的后遗症。 教训: 根据代谢性碱中毒和肾消耗低钾血症患者血压正常的情况,排除PA还为时过早。此外,对于低钾病因不明的血压正常患者,应考虑PA,以避免延误诊断和治疗。

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影响因子:4.46
发表时间:2020-03-01
DOI:10.1111/nyas.14205
作者列表:["Fan L","Zhuang Y","Wang Y","Liu X","Liu D","Xiang B","He M","Zhang Z","Li Y","Wang Y","Zhu X","Ye H"]

METHODS::Hypokalemia is a common feature in patients with Cushing's syndrome (CS). Whether the occurrence of hypokalemia is associated with cortisol and adrenocorticotropic hormone (ACTH) levels is still unclear. Approximately 80% of cases of endogenous CS are due to Cushing's disease (CD). The purpose of this study was to determine the association of hypokalemia with cortisol and ACTH levels in patients with CD. The retrospective study included 195 patients with CD referred to our medical center from January 2011 to December 2017. The results show that 25.64% (50/195) of the patients had hypokalemia. The 24-h urinary free cortisol (UFC) and plasma cortisol levels were significantly higher in patients with hypokalemia than those with normokalemia (P < 0.05). Plasma ACTH levels were similar between the patients with hypokalemia and normokalemia (P > 0.05). Cortisol levels were negatively correlated with plasma potassium levels (08:00: r = -0.344 (P < 0.01), 00:00: r = -0.435 (P < 0.01); 24-h UFC: r = -0.281 (P < 0.05)). There was no significant correlation between the plasma ACTH and potassium (08:00: r = -0.093 (P > 0.05), 00:00: r = -0.184 (P > 0.050)). Our current data suggest that cortisol level, instead of ACTH level, is correlated with plasma potassium level. A high cortisol level may be the principal cause of hypokalemia.

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影响因子:6.93
发表时间:2020-04-15
DOI:10.1002/ijc.32654
作者列表:["Ghosal S","Das S","Pang Y","Gonzales MK","Huynh TT","Yang Y","Taieb D","Crona J","Shankavaram UT","Pacak K"]

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肾上腺疾病方向

主要包括肾上腺皮质疾病、肾上腺肿瘤、先天性肾上腺增生、肾上腺机能不全、肾上腺皮质机能亢进等疾病。

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