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Levothyroxine supplementation in hypothyroid bitches during pregnancy.

妊娠期甲状腺功能减退母犬补充左旋甲状腺素。

  • 影响因子:2.33
  • DOI:10.1016/j.theriogenology.2019.09.036
  • 作者列表:"Cecere J","Purswell B","Panciera D
  • 发表时间:2020-01-15
Abstract

:Hypothyroidism is the most common endocrine disease in dogs and has been shown to have a hereditary nature in many breeds. Previous studies have documented decreased fertility in bitches with experimentally-induced hypothyroidism, decreased viability at birth, increased periparturient mortality, and reduced birth weight in pups born to hypothyroid dogs. Hypothyroid women have an increased demand for exogenous thyroxine throughout gestation in order to maintain normal plasma concentrations of thyroid hormones and produce neuropsychologically normal children. This study was performed to determine if pregnancy causes a similar need for increased levothyroxine dosages in dogs to maintain a euthyroid state. Serum was harvested from blood collected from six bitches with experimentally-induced hypothyroidism that were receiving standard thyroid hormone replacement therapy and from four euthyroid control bitches. Thyroid function tests performed on these samples included total thyroxine (T4), free T4 (fT4), thyroid stimulating hormone (TSH), and 3,5,3'-triiodothyronine (T3). Thyroid function tests were measured from ovulation through the end of pregnancy. All bitches whelped normal litters. Euthyroid bitches had no significant alterations in their hormone concentrations throughout pregnancy. None of the supplemented hypothyroid bitches had clinical signs of hypothyroidism throughout the study. Serum concentrations of T4 and fT4 were elevated compared to ovulation at multiple sample points during gestation in supplemented dogs. The results from this study indicate that standard levothyroxine supplementation is adequate to maintain a euthyroid state during pregnancy in experimentally-induced hypothyroid dogs. In addition, there is no evidence that canine thyroid profiles in euthyroid dogs are altered during gestation.

摘要

: 甲状腺功能减退症是狗最常见的内分泌疾病,在许多品种中已被证明具有遗传性。以前的研究已经证明,实验性甲状腺功能减退的母狗的生育力下降,出生时的活力下降,围产期死亡率增加,甲状腺功能减退的狗出生的幼崽的出生体重下降。甲状腺功能减退的妇女在整个妊娠期间对外源性甲状腺素的需求增加,以维持甲状腺激素的正常血浆浓度并产生神经心理正常的儿童。进行这项研究是为了确定妊娠是否引起狗对增加左旋甲状腺素剂量以维持甲状腺功能正常状态的类似需要。从接受标准甲状腺激素替代疗法的6只实验性甲状腺功能减退症母狗和4只甲状腺功能正常对照母狗的血液中收集血清。对这些样品进行的甲状腺功能测试包括总甲状腺素 (T4) 、游离T4 (fT4) 、促甲状腺激素 (TSH) 和3,5,3 '-三碘甲状腺原氨酸 (T3)。甲状腺功能测试从排卵到妊娠结束进行测量。所有的婊子都是正常的垃圾。甲状腺功能正常的母犬在整个妊娠期间其激素浓度没有显著变化。在整个研究中,补充的甲状腺功能减退母犬都没有甲状腺功能减退的临床症状。在补充的狗的妊娠期间,与多个样本点处的排卵相比,T4和fT4的血清浓度升高。这项研究的结果表明,在实验诱导的甲状腺功能减退犬中,标准左旋甲状腺素补充足以维持妊娠期间的甲状腺功能正常。此外,没有证据表明正常甲状腺狗的犬甲状腺特征在妊娠期间发生了改变。

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DOI:10.1159/000496502
作者列表:["Nishino M","Krane JF"]

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影响因子:2.32
发表时间:2020-01-01
来源期刊:The Laryngoscope
DOI:10.1002/lary.27947
作者列表:["Ji T","Chen J","Mou J","Ni X","Guo Y","Zhang J","Wang S","Wang W","Zhang X","Tai J"]

METHODS:OBJECTIVES/HYPOTHESIS:The definition of large-volume pathologic N1 metastases has been changed in the 2017 version 2 of the National Comprehensive Cancer Network guidelines, leading to a controversy over the optimal surgical approach selection for patients with biopsy-proven papillary thyroid carcinoma (PTC). The aim of this study was to investigate the therapeutic efficacy of total thyroidectomy (TT) and thyroid lobectomy (TL) for these patients. STUDY DESIGN:Retrospective population-based database analysis. METHODS:A total of 906 consecutive PTC patients with pathologic N1 metastases (>5 involved nodes with metastases ≤5 mm in the largest dimension) were retrieved from the Surveillance, Epidemiology, and End Results database, and divided into two groups (≤2 mm, >2-5 mm) based on the size of the extent of disease. Overall survival (OS) was then compared between patients treated with TT and TL, followed by Cox proportional hazards regression analysis to explore multiple prognostic factors. RESULTS:OS favored TT compared with TL in patients with more than five involved nodes and metastases >2 to 5 mm in the largest dimension (P < .05). Cox analysis showed that the TL was not an independent factor associated with poorer OS than TT in these patients (P > .05). CONCLUSIONS:TT showed better survival than TL for patients with more than five involved nodes and metastases >2 to 5 mm in the largest dimension. For patients with more than five involved nodes and metastases ≤2 mm in the largest dimension, either TT or TL can be recommended because there was no difference in survival. LEVEL OF EVIDENCE:NA Laryngoscope, 130:269-273, 2020.

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影响因子:2.09
发表时间:2020-01-01
DOI:10.2174/1573399815666190417145440
作者列表:["Goes LG","da Luz Eltchechem C","Wouk J","Malfatti CRM","da Silva LA"]

METHODS:BACKGROUND:Obesity, diabetes mellitus may be related to the health, the relationship and the physiological capacity of the production of thyroid hormones (TH), triiodothyronine (T3) and thyroxine (T4). OBJECTIVES:The main aims of this review are to describe the relationship between obesity, appetite, weight management, hormonal mechanisms of diabetes mellitus and hypothyroidism post-bariatric surgery. METHODOLOGY:An in-depth literature search was conducted to identify scientific studies, which analyzed the correlation between diabetes mellitus and hypothyroidism post-bariatric surgery. RESULTS:Bariatric surgery decreases hypothyroidism, reduces the need for pharmacological action (such as levothyroxine), controls the weight and body fat and increases the sensitivity to leptin and insulin. CONCLUSION:The reduction of the stomach and intestine by bariatric surgery is an evolutionary and beneficial action, because it may lead to a drastic decrease on numbers of conditions such as diabetes, obesity, hypothyroidism, and others. Thus, new studies should also focus on patients' post-operatory conditions, such as lifetime, regulation and functioning of organs after reduced nutrition, and consumption and delivery of nutrients to health maintenance.

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甲状腺疾病方向

主要分为内科治疗的甲状腺疾病和外科治疗的甲状腺疾病两大类。内科治疗的甲状腺疾病主要包括甲状腺功能亢进症和甲状腺炎症。外科治疗的甲状腺疾病包括甲状腺肿和甲状腺肿瘤。

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