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Night shift work surrounding pregnancy and offspring risk of atopic disease.

夜班工作围绕怀孕和后代的特应性疾病的风险。

  • 影响因子:3.02
  • DOI:10.1371/journal.pone.0231784
  • 作者列表:"Rada S","Strohmaier S","Drucker AM","Eliassen AH","Schernhammer ES
  • 发表时间:2020-04-16
Abstract

BACKGROUND:Night shift work surrounding pregnancy may contribute to the risk of developing atopic diseases in offspring due to alterations in the prenatal environment, from stress. OBJECTIVE:To examine the association of maternal night shift work surrounding pregnancy and offspring risk of developing atopic diseases from childhood to adolescence. METHODS:We examined the association between night shift work before and during pregnancy among 4,044 mothers in the Nurses' Health Study II (NHSII) and atopic dermatitis, asthma and hay fever risk in 4,813 of their offspring enrolled in the Growing Up Today Study (GUTS). Mothers reported whether GUTS participants had ever been diagnosed with atopic dermatitis, asthma or hay fever in the GUTS Mothers' questionnaire. Generalized estimating equation regression models were used to estimate multivariable adjusted odds ratios (OR) and 95% confidence intervals (CIs). RESULTS:There were no significant associations between pre-conception maternal night shift work and risk of atopic dermatitis, asthma or hay fever in their offspring. Among 545 mothers with information on night shift work during pregnancy, shift work also was not associated with atopic dermatitis, asthma or hay fever in the offspring. Stratified analyses by history of parental atopy and maternal chronotype showed some statistically significant findings, but they were inconsistent and no significant interaction was seen with increasing duration of night shift work. CONCLUSION:In this study, night shift work before and during pregnancy did not increase offspring risk of developing atopic dermatitis, asthma or hay fever.

摘要

背景: 怀孕期间的夜班工作可能会导致后代发生特应性疾病的风险,因为产前环境的改变,压力。 目的: 研究母亲在怀孕期间的夜班工作与后代从儿童期到青春期发生特应性疾病的风险之间的关系。 方法: 我们调查了护士健康研究II (NHSII) 中4,044名母亲怀孕前和怀孕期间的夜班工作与4,813名参加今日成长研究 (GUTS) 的后代的特应性皮炎、哮喘和花粉发热风险之间的关系。母亲在GUTS母亲的问卷中报告了GUTS参与者是否曾被诊断患有特应性皮炎,哮喘或花粉发热。广义估计方程回归模型用于估计多变量调整后的比值比 (OR) 和95% 置信区间 (ci)。 结果: 孕前母亲夜班工作与其后代患特应性皮炎、哮喘或花粉发热的风险之间没有显著关联。在怀孕期间有夜班工作信息的545名母亲中,轮班工作也与后代的特应性皮炎,哮喘或花粉发热无关。根据父母特应性病史和母亲时间类型进行分层分析,结果显示有一些统计学意义,但不一致,并且没有观察到与夜班工作时间延长有显著交互作用。 结论: 在这项研究中,怀孕前和怀孕期间的夜班工作不会增加后代患特应性皮炎,哮喘或花粉发热的风险。

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来源期刊:Pulmonology
DOI:10.1016/j.pulmoe.2018.10.009
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鼻部疾病包括外鼻、鼻前庭、鼻腔和鼻窦的疾病。可分为感染、出血、变态反应、肿瘤、外伤、异物、先天性畸形和结构异常等。

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