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Comparison of clinical features of acute lower respiratory tract infections in infants with RSV/HRV infection, and incidences of subsequent wheezing or asthma in childhood.

RSV/HRV感染婴儿急性下呼吸道感染的临床特征比较,以及随后儿童期喘息或哮喘的发生率。

  • 影响因子:2.79
  • DOI:10.1186/s12879-020-05094-4
  • 作者列表:"Ding Q","Xu L","Zhu Y","Xu B","Chen X","Duan Y","Xie Z","Shen K
  • 发表时间:2020-05-30
Abstract

BACKGROUND:To compare the clinical characteristics of acute lower respiratory tract infections (ALRTIs) caused by respiratory syncytial virus (RSV) and human rhinovirus (HRV) and to explore the relationship between the development of recurrent wheezing/asthma and RSV/ HRV infections in infancy. METHODS:Retrospective study was conducted to compare the clinical characteristics of acute lower respiratory tract infections (ALRTIs). Hospitalized patients with ALRTIs from March 2007 to December 2016 were screened. Single RSV cases (s-RSV), single HRV cases (s-HRV), and cases who had co-infection with the two viruses were enrolled. Follow-up was performed to determine whether either specific respiratory virus infection was related to subsequent development of recurrent wheezing/asthma. RESULTS:The s-RSV children were the youngest (P = 0.021), they experienced the most serious condition (P < 0.001) and respiratory failure (P < 0.001), they also required highest demand of oxygen therapy (P < 0.001). And in s-RSV group, the incidence of development of recurrent wheezing was significantly higher in subgroup with the family history of wheezing than that without (P < 0.001). CONCLUSION:The s-RSV cases suffered from the worst severity of illness, respiratory failure and required highest demand of oxygen therapy. Recurrent wheezing was more common in s-RSV group with family history of wheezing than those without.

摘要

背景: 比较呼吸道合胞病毒 (RSV) 和人鼻病毒 (HRV) 所致急性下呼吸道感染 (ALRTIs) 的临床特点,探讨婴幼儿反复喘息/哮喘的发生与RSV/ HRV感染的关系。 方法: 回顾性分析比较急性下呼吸道感染 (ALRTIs).筛选2007年3月至2016年12月住院的alrti患者。纳入单一RSV病例 (s-rsv) 、单一HRV病例 (s-hrv) 和两种病毒共感染的病例。随访,以确定是否特异性呼吸道病毒感染有关的后续发展反复喘息/哮喘. 结果: s-rsv患儿年龄最小 (p <0.021),病情最严重 (p <0.001),呼吸衰竭 (p <0.001),对氧疗的需求最高 (p <0.001)。在s-RSV组中,有喘息家族史的亚组反复喘息的发生率明显高于无喘息家族史的亚组 (p <0.001)。 结论: s-rsv病例病情最严重,呼吸衰竭,需用氧量最高。有喘息家族史的s-rsv组反复喘息较无喘息史者多见。

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呼吸过敏性疾病方向

当空气中的花粉、细菌等过敏原通过呼吸作用进入到肺部,就容易引起鼻子、咽喉、气管等部位出现不适的症状,可能引发多种呼吸过敏性疾病的发作。其中主要包括外源性过敏性肺泡炎、变应性支气管肺曲霉菌病、哮喘及过敏性鼻炎。

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