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Environmental exposure to lead and cadmium and hearing loss in Chinese adults: A case-control study.

中国成人环境铅和镉暴露与听力损失: 一项病例对照研究。

  • 影响因子:3.02
  • DOI:10.1371/journal.pone.0233165
  • 作者列表:"Wang DH","Xu H","Zheng YH","Gu DS","Zhu YJ","Ren Y","Wang SC","Yang L","Xu LW
  • 发表时间:2020-05-20
Abstract

:Hearing loss is the second most common nonfatal problem affecting the Chinese population. Historical studies have suggested an association between exposure to heavy metals, such as cadmium and lead, and hearing loss. Few studies have investigated this relationship in the general population in China. We conducted a case-control study with 1008 pairs of participants from a cross-sectional epidemiological survey conducted in Zhejiang Province. A self-designed questionnaire was adopted to collect information on demographics, chronic diseases, lifestyles and environmental noise. Pure-tone averages of hearing thresholds at frequencies of 0.5, 1, 2, and 4 kHz were computed. Blood lead and cadmium levels were analyzed with an atomic absorption spectrometer. After adjusting for all other potential confounding factors, compared with the lowest blood cadmium quartile (0.00-0.53 μg/L), blood cadmium quartile 2 (0.54-0.92 μg/L), quartile 3 (0.93-1.62 μg/L) and quartile 4 (1.63-57.81 μg/L) exhibited significantly elevated risks for hearing loss, with odds ratios of 1.932 (95% CI: 1.356-2.751), 2.036 (95% CI: 1.423-2.914) and 1.495 (95% CI: 1.048-2.133), respectively (P-trend<0.001). However, an association of lead with hearing loss was not found. Young age (less than 60 years), male sex and current smoking were associated with increased blood cadmium concentration. Additionally, a positive association between blood cadmium and lead concentrations was found. Therefore, we conclude that exposure to environmental cadmium may be a risk factor for hearing loss among the general population in China.

摘要

: 听力损失是影响中国人群的第二大常见非致命性问题。历史研究表明,重金属 (如镉和铅) 暴露与听力损失之间存在关联。很少有研究在中国普通人群中调查这种关系。我们对来自浙江省横断面流行病学调查的1008对参与者进行了病例对照研究。采用自行设计的调查问卷,收集人口统计学、慢性病、生活方式、环境噪声等信息。计算频率为0.5、1、2和4 kHz时的纯音听阈平均值。用原子吸收光谱仪分析血铅和镉水平。在调整所有其他潜在混杂因素后,与最低血镉四分位数 (0.00-0.53 μ g/L) 、血镉四分位数2 (0.54-0.92 μ g/L) 、四分位数3 (0.93-1.62 μ g/L) 和四分位数4 (1.63-57.81 μ g/L) 相比表现出显著升高的听力损失风险,比值比为1.932 (95% CI: 1.356-2.751),分别为2.036 (95% CI: 1.423-2.914) 和1.495 (95% CI: 1.048-2.133) (P趋势 <0.001)。然而,没有发现铅与听力损失的关联。年轻 (小于60岁) 、男性和目前吸烟与血镉浓度升高有关。此外,发现血镉和铅浓度之间呈正相关。因此,我们认为环境镉暴露可能是中国普通人群听力损失的危险因素。

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影响因子:2.05
发表时间:2020-02-01
DOI:10.1136/archdischild-2018-315866
作者列表:["Butcher E","Dezateux C","Knowles RL"]

METHODS:OBJECTIVE:While several perinatal risk factors for permanent childhood hearing impairment (PCHI) are known, association with gestational length remains unclear. We hypothesised that shorter gestational length predicts higher PCHI risk. DESIGN:19 504 participants from the UK Millennium Cohort Study (born 2000-2002, prior to newborn screening). METHODS:Multivariable discrete-time survival analysis to examine associations between parent-reported PCHI by age 11 years and gestational length, plus other prespecified factors. RESULTS:PCHI affected 2.1 per 1000 children (95% CI 1.5 to 3.0) by age 11; however, gestational length did not predict PCHI risk (HR, 95% CI 1.00, 0.98 to 1.03 per day increase). Risk was increased in those with neonatal illness, with or without admission to neonatal care (6.33, 2.27 to 17.63 and 2.62, 1.15 to 5.97, respectively), of Bangladeshi or Pakistani ethnicity (2.78, 1.06 to 7.31) or born to younger mothers (0.92, 0.87 to 0.97 per year). CONCLUSION:Neonatal illness, rather than gestational length, predicts PCHI risk. Further research should explore associations with ethnicity.

关键词: 耳聋 流行病学
翻译标题与摘要 下载文献
影响因子:1.09
发表时间:2020-01-01
DOI:10.1016/j.bjorl.2018.10.007
作者列表:["Öçal R","Akın Öçal FC","Güllüev M","Alataş N"]

METHODS:INTRODUCTION:Sudden hearing loss is a significant otologic emergency. Previous studies have revealed a coexistence of sudden hearing loss with chronic inflammation. The predictive importance of C-reactive protein/albumin values as a prognostic factor has been shown in various inflammatory and tumoral conditions. OBJECTIVES:The aim of this study was to determine whether the C-reactive protein/albumin ratio in sudden hearing loss can be used for prognostic purposes and whether there is a relationship between the neutrophil/lymphocyte ratio and the C-reactive protein/albumin ratio. METHODS:A retrospective examination was made of 40 patients diagnosed with idiopathic sudden hearing loss and a control group of 45 healthy subjects. The pure tone averages of all the patients were determined on first presentation and repeated at 3 months after the treatment. The patients were separated into 2 groups according to the response to treatment. The neutrophil/lynphocyte ratio and the C-reactive protein/albumin ratios were calculated from the laboratory tests. RESULTS:The patients included 16 females and 24 males with a mean age of 44.1±14.2 years and the control group was composed of 23 females and 22 males with a mean age of 42.2±13.8 years. The mean C-reactive protein/albumin ratio was 0.95±0.47 in the patient group and 0.74±0.13 in the control group. The difference was statistically significant (p=0.009). The mean C-reactive protein/albumin ratio was 0.79±0.12 in the response to treatment group and 1.27±0.72 in the non-response group, with no significant difference determined between the groups (p=0.418). The mean neutrophil/lymphocyte ratio was 3.52±3.00 in the response to treatment group and 4.90±4.60 in the non-response group, with no statistically significant difference determined between the groups (p=0.261). CONCLUSION:C-reactive/albumin ratio was significantly higher in patients with sudden hearing loss than in the control group. Although C-reactive protein/albumin ratio was found to be lower in sudden hearing loss patients who responded to treatment compared to those who did not, the difference between two groups was not statistically significant.

影响因子:1.09
发表时间:2020-01-01
DOI:10.1016/j.bjorl.2018.10.006
作者列表:["Scarabello EM","Lamônica DAC","Morettin-Zupelari M","Tanamati LF","Campos PD","Alvarenga KF","Moret ALM"]

METHODS:INTRODUCTION:The cochlear implant is an effective device for children with severe and/or profound prelingual hearing loss, since it provides considerable improvement in oral language acquisition through the auditory pathway. The use of a cochlear implant contributes to the development of auditory perception, favoring the acquisition of the linguistic processes related to communication skills, which might have a positive effect on other areas of development. OBJECTIVE:The aim of this study was to verify the performance of children using cochlear implants for expressive and receptive oral language. METHODS:This was a prospective cross-sectional study that used the following tests: Child language test in the phonology, vocabulary, fluency and pragmatics areas, and the Peabody picture vocabulary test. Thirty children participated in this study, of both genders, aged between 36 and 72 months, with severe and/or profound bilateral sensorineural hearing loss, without other impairments and users of unilateral cochlear implant with full electrode insertion for a minimum of 12 months. RESULTS:The longer duration of the cochlear implant use, the younger age at surgery and the better performance in the auditory perception of speech influenced the performance in expressive and receptive oral language. Even though when compared to the normative language acquisition process, the results showed that these children had patterns of linguistic skills that are below their chronological age; the results indicate that these children are developing expressive and receptive oral language skills, and this is the outcome that should be taken into account in this study. CONCLUSION:The longer duration of the cochlear implant use, the younger age at surgery and the better performance in the auditory perception of speech influenced the performance in expressive and receptive oral language skills, but not in all the studied semantic categories.

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