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Imipenem/cilastatin sodium/relebactam fixed combination to treat urinary infections and complicated intra-abdominal bacterial infections.

亚胺培南/西司他丁钠/雷巴坦固定组合治疗泌尿系感染和复杂的腹腔内细菌感染。

  • 影响因子:1.08
  • DOI:10.1358/dot.2020.56.4.3075796
  • 作者列表:"Thakare R","Dasgupta A","Chopra S
  • 发表时间:2020-04-01
Abstract

:Imipenem/cilastatin sodium/relebactam is a combination of imipenem/cilastatin, a U.S. Food and Drug Administration (FDA)-approved antibiotic, and β-lactamase inhibitor relebactam which has been developed for the treatment of complicated urinary tract infection (cUTI) and complicated intra-abdominal infection (cIAI) due to drug-resistant bacterial pathogens. The combination (Recarbrio) has been designated as a qualified infectious disease product (QIDP) and obtained FDA approval in 2019 for the treatment of cUTI and cIAI caused by susceptible Gram-negative microorganisms in adult patients with limited or no alternative treatment options. The product was also approved by the European Medicines Agency (EMA) in 2020 for the treatment of infections due to aerobic Gram-negative organisms in adults with limited treatment options.

摘要

: 亚胺培南/西司他丁钠/雷巴坦是美国食品药品监督管理局 (FDA) 批准的抗生素亚胺培南/西司他丁与 β-内酰胺酶抑制剂雷巴坦的组合,已被开发用于治疗复杂性尿路感染 (cUTI) 和复杂性腹腔感染 (cIAI) 由于耐药的细菌病原体。该组合 (Recarbrio) 已被指定为合格的传染病产品 (QIDP),并于2019年获得FDA批准,用于治疗由易感革兰氏阴性微生物引起的cUTI和cIAI成年患者,其替代治疗方案有限或没有替代治疗方案。该产品还在2020年被欧洲药品管理局 (EMA) 批准用于治疗由成人需氧革兰氏阴性微生物引起的感染,治疗选择有限。

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影响因子:1.46
发表时间:2020-01-01
来源期刊:The Journal of urology
DOI:10.1097/JU.0000000000000521
作者列表:["Parizi JLG","Leal da Cruz M","Andrade MC","Garrone G","Ottoni SL","Cavalheiro S","Moron A","Macedo A Jr"]

METHODS:PURPOSE:In utero myelomeningocele closure is a valid alternative to postnatal repair with unclear benefits to bladder function. We compared bladder status in patients who underwent fetal myelomeningocele surgery versus postnatal repair. MATERIALS AND METHODS:We retrospectively reviewed our database, with group 1 consisting of in utero surgery and group 2 consisting of postnatal repair. Group 3 was a subgroup of group 2, including patients initially presenting at age less than 12 months. We recorded medical history, radiological investigation with renal ultrasonography, voiding cystourethrography, urodynamic evaluation and clinical outcome of the bladder pattern after treatment. RESULTS:We identified 88 patients in group 1, 86 in group 2 and 38 in group 3. The incidence of urinary tract infection was higher in the postnatal period (45% vs 20%). Hydronephrosis occurred in 20.7%, 22.6% and 28.9% of patients in groups 1, 2 and 3, respectively. Vesicoureteral reflux was diagnosed in 15% in all groups. Urodynamic data showed a higher prevalence of detrusor overactivity in group 1 and no difference in other urodynamic parameters. The high risk bladder pattern at initial evaluation occurred in 56%, 50% and 46% of patients in groups 1, 2 and 3, respectively. There was a trend to decrease the percentages of the high risk bladder pattern and to increase the normal pattern after treatment in all groups. CONCLUSIONS:In utero repair did not improve urological parameters compared to repair in the postnatal period.

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影响因子:2.09
发表时间:2020-04-01
DOI:10.1016/j.jiph.2019.08.014
作者列表:["Kayode A","Okunrounmu P","Olagbende A","Adedokun O","Hassan AW","Atilola G"]

METHODS::The development and evolution of antimicrobial resistance (AMR) in pathogens has been reported to be one of the major issues confronting the global health community. The aim of this study was to examine the period prevalence of antibiotic resistance, as well as the trends and patterns in sensitivity profile of enteric bacteria isolated from urine samples of patients with UTIs in a teaching Hospital in south west Nigeria. Urine samples were collected from 77 patients with UTIs from February 2017 to October 2018. Standard laboratory methods were used for urine sample culture and bacterial identification. The Kirby-Bauer disk diffusion method was used to evaluate antimicrobial sensitivity. Predominant enteric bacteria isolates were Escherichia coli (24, 39.3%), Salmonella species (12, 19.7%), Klebsiella species (4, 6.6%), Providencia species (6, 9.8%), Proteus species (8, 13.1%), Serratia species (2, 3.3%), Yersinia species (1, 1.6%) and Morganella species (4, 6.6%). A large proportion (90.2%) of isolates obtained were multi-drug resistant. High resistance in amoxycillin-clavulanate (98%), cefuroxime (92%), erythromycin (90%) and ceftazidime (84%) were recorded. These results emphasize the importance of continuous screening and surveillance programmes for detection of AMR in enteric bacteria of public health importance.

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影响因子:1.09
发表时间:2020-01-01
DOI:10.1097/CIN.0000000000000562
作者列表:["Park JI","Bliss DZ","Chi CL","Delaney CW","Westra BL"]

METHODS::Massive generation of health-related data has been key in enabling the big data science initiative to gain new insights in healthcare. Nursing can benefit from this era of big data science, as there is a growing need for new discoveries from large quantities of nursing data to provide evidence-based care. However, there are few nursing studies using big data analytics. The purpose of this article is to explain a knowledge discovery and data mining approach that was employed to discover knowledge about hospital-acquired catheter-associated urinary tract infections from multiple data sources, including electronic health records and nurse staffing data. Three different machine learning techniques are described: decision trees, logistic regression, and support vector machines. The decision tree model created rules to interpret relationships among associated factors of hospital-acquired catheter-associated urinary tract infections. The logistic regression model showed what factors were related to a higher risk of hospital-acquired catheter-associated urinary tract infections. The support vector machines model was included to compare performance with the other two interpretable models. This article introduces the examples of cutting-edge machine learning approaches that will advance secondary use of electronic health records and integration of multiple data sources as well as provide evidence necessary to guide nursing professionals in practice.

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翻译标题与摘要 下载文献
尿路感染方向

尿路感染又称泌尿系统感染,是尿路上皮对细菌侵入导致的炎症反应,通常伴随有菌尿和脓尿。尿路感染根据感染部位分为上尿路感染和下尿路感染。

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