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Kidney function in minority children and adolescents with metabolically healthy and unhealthy obesity.

代谢健康和不健康肥胖的少数民族儿童和青少年的肾功能。

  • 影响因子:1.55
  • DOI:10.1111/cob.12345
  • 作者列表:"Arora S","Dunkley L","Waldman LM","Chin VL","Umpaichitra V
  • 发表时间:2020-02-01
Abstract

:Metabolic syndrome and/or body mass index (BMI) ≥40 kg/m2 are risk factors for kidney function decline in the general population. To compare creatinine (Cr), estimated glomerular filtration rate (eGFR) and blood urea nitrogen (BUN) between minority children and adolescents with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO), a chart review was conducted on subjects aged 4 to 20 years with BMI ≥95th percentile from July 2014 to April 2017. They were stratified into MHO and MUO groups. Cr, eGFR and BUN were studied. Total n = 277: MHO n = 105 vs MUO n = 172. Cr was higher and BUN was lower in MUO whereas eGFR did not differ between the groups. Using general linear model, we found that metabolic status predicted BUN (P = .009) but not Cr or eGFR. When age, sex and Tanner stage matched, BUN, Cr and eGFR were similar between the groups. Higher BUN in MHO could be due to higher dietary protein intake. Subjects were divided into BMI ≥40 vs <40 kg/m2 , BUN and eGFR were not different. A trend towards higher Cr in those with BMI ≥40 kg/m2 (P = .054) was found; the group being older and taller. After age and height matching, all outcomes were not different. Higher Cr was found in those with elevated blood pressures vs the MHO (P = .047). Those with diastolic blood pressure (DBP) ≥90th percentile had higher Cr than those with systolic blood pressure ≥90th percentile (P = .017). Children and adolescents with MUO, and those with BMI ≥40 kg/m2 did not appear to have early diminished kidney function. Higher Cr, although in normal range, occurred in those with abnormal DBP.

摘要

: 代谢综合征和/或体重指数 (BMI) ≥ 40千克kg/m2是普通人群肾功能下降的危险因素。为了比较代谢健康肥胖 (MHO) 和代谢不健康肥胖 (MUO) 的少数民族儿童和青少年之间的肌酐 (Cr),估计肾小球滤过率 (eGFR) 和血尿素氮 (BUN),从2014年7月至2017年4月,对4至20岁BMI ≥ 第95百分位数的受试者进行图表审查。将他们分为MHO组和MUO组。研究Cr、eGFR和BUN。总n = 277: MHO n = 105对MUO n = 172。MUO中的Cr较高且BUN较低,而eGFR在各组之间没有差异。使用一般线性模型,我们发现代谢状态预测BUN (P = .009) 而不是Cr或eGFR。当年龄、性别和Tanner分期匹配时,各组之间的BUN、Cr和eGFR相似。MHO中较高的BUN可能是由于较高的膳食蛋白质摄入量。受试者分为BMI ≥ 40 vs <40千克kg/m2,BUN和eGFR无差异。发现BMI ≥ 40千克kg/m2 (P = .054) 的患者有更高Cr的趋势; 该组年龄较大和较高。在年龄和身高匹配后,所有结果没有差异。血压升高者Cr高于MHO (P = .047)。舒张压 (DBP) ≥ 90百分位数者Cr高于收缩压 ≥ 90百分位数者 (P = .017)。患有MUO的儿童和青少年以及BMI ≥ 40千克kg/m2的儿童和青少年似乎没有早期肾功能减退。虽然在正常范围内,但在DBP异常者中发生较高的Cr。

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影响因子:0.85
发表时间:2020-01-02
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DOI:10.1093/labmed/lmz025
作者列表:["Tang J","Jiang Y","Ge Z","Wu H","Chen H","Dai J","Gu Y","Mao X","Lu J"]

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