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A Public Health Laboratory Response to the Pandemic.

公共卫生实验室应对大流行。

  • 影响因子:3.65
  • DOI:10.1128/JCM.01110-20
  • 作者列表:"Pabbaraju K","Wong AA","Douesnard M","Ma R","Gill K","Dieu P","Fonseca K","Zelyas N","Tipples GA
  • 发表时间:2020-07-23
Abstract

:An outbreak of coronavirus disease 2019 (COVID-19) caused by a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) began in Wuhan, Hubei, China, in December 2019 and spread rapidly worldwide. The response by the Alberta Precision Laboratories, Public Health Laboratory (ProvLab), AB, Canada, included the development and implementation of nucleic acid detection-based assays and dynamic changes in testing protocols for the identification of cases as the epidemic curve increased exponentially. This rapid response was essential to slow down and contain transmission and provide valuable time to the local health authorities to prepare appropriate response strategies. As of May 24, 2020, 236,077 specimens were tested, with 6,475 (2.74%) positives detected in the province of Alberta, Canada. Several commercial assays are now available; however, the response from commercial vendors to develop and market validated tests is a time-consuming process. In addition, the massive global demand made it difficult to secure a reliable commercial supply of testing kits and reagents. A public health laboratory serves a unique and important role in the delivery of health care. One of its functions is to anticipate and prepare for novel emerging pathogens with a plan for pandemic preparedness. Here, we outline the response that involved the development and deployment of testing methodologies that evolved as SARS-CoV-2 spread worldwide, the challenges encountered, and mitigation strategies. We also provide insight into the organizational structure of how a public health response is coordinated in Alberta, Canada, and its benefits.

摘要

: 由新型冠状病毒肺炎冠状病毒 (新型冠状病毒冠状病毒2 [新型冠状病毒]) 引起的2019 (SARS-CoV-2) 冠状病毒病疫情始于2019年12月中国湖北武汉,并在全球迅速蔓延。加拿大艾伯塔省精准实验室公共卫生实验室 (ProvLab) 的回应包括开发和实施基于核酸检测的检测方法,以及随着流行病曲线呈指数增长,用于识别病例的检测方案的动态变化。这种快速反应对于减缓和遏制传播至关重要,并为地方卫生当局准备适当的应对战略提供宝贵时间。截至2020年5月24日,检测了236,077份标本,在加拿大阿尔伯塔省检测到6,475份 (2.74%) 阳性。现在有几种商业测定法可用; 然而,商业供应商对开发和市场验证测试的响应是一个耗时的过程。此外,巨大的全球需求使得难以确保检测试剂盒和试剂的可靠商业供应。公共卫生实验室在提供卫生保健方面发挥着独特而重要的作用。其功能之一是预测和准备新出现的病原体,并制定大流行防备计划。在这里,我们概述了随着SARS-CoV-2在世界范围内传播而演变的测试方法的开发和部署,遇到的挑战和缓解策略。我们还深入了解加拿大艾伯塔省如何协调公共卫生应对措施的组织结构及其好处。

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DOI:10.1093/labmed/lmz030
作者列表:["Yang R","Zhang R","Zhang Y","Huang Y","Liang H","Gui G","Gong S","Wang H","Xu M","Fan J"]

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影响因子:4.51
发表时间:2020-01-01
DOI:10.1016/j.cmi.2019.05.010
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分子诊断技术方向

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