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Retroperitoneal lymphatic malformation in a dog.

狗腹膜后淋巴管畸形。

  • 影响因子:1.58
  • DOI:10.1186/s13028-020-0506-9
  • 作者列表:"Driessen F","Cushing T","Baines SJ
  • 发表时间:2020-02-01
Abstract

BACKGROUND:Lymphatic vascular malformations are rare findings in canine patients with six reports available in veterinary literature. Retroperitoneal cystic lymphatic malformations have not been described previously in canine patients and neither has the use of immunohistochemistry to determine their origin, i.e. vascular versus lymphatic. CASE PRESENTATION:An 8-year-old neutered female Cocker spaniel was referred for pollakiuria, dysuria and a painful abdomen. Computed tomography scanning of the abdomen showed a fluid filled structure adjacent to the urinary bladder. During surgical exploration, a thin walled cystic structure with sero-haemorrhagic fluid was found, extending from the retroperitoneal space into the abdomen. The mass was excised and submitted for histopathology, revealing a cystic mass lined by a fibrovascular capsule within the retroperitoneal/mesenteric adipose tissue. The inner surface of the cyst was lined by a single layer of bland, flattened spindle cells. Intramural blood vessels were well differentiated, with perivascular haemorrhage. On recurrence 11 months later, the mass was excised for the second time and a PleuralPort (Norfolk Animal products) was placed. Fifteen months after initial presentation, progression occurred with haemorrhagic fluid in the cystic space, pleural- and abdominal cavities and the owners opted for euthanasia. Histopathology and positive immunohistochemistry for lymphatic markers lymphatic vessel endothelial hyaluronic acid receptor-1 (LYVE-1) and prospero homeobox protein-1 (PROX-1) confirmed a lymphatic vascular origin of the cystic structure. CONCLUSIONS:To our experience, a definitive diagnosis of retroperitoneal cystic malformation of lymphatic origin could be done only by combining the clinical presentation, advanced imaging, histopathology and LYVE-1 and PROX-1 immunohistochemistry. This is the first report of a vascular malformation in a dog where immunohistochemistry was used to make a final diagnosis. A lymphatic malformation, even if rare, should be added on the list of the differential diagnosis in a patient with a retroperitoneal cystic structure containing serohaemorrhagic fluid. Results of this case report can aid in diagnosis of future cases, however, further studies on therapy and management are needed to provide additional information about optimal treatment of these patients.

摘要

背景: 淋巴管畸形在犬患者中是罕见的,兽医文献中有6篇报道。以前没有在犬患者中描述过腹膜后囊性淋巴管畸形,也没有使用免疫组织化学来确定它们的起源,即血管与淋巴。 病例介绍: 一只8岁的雌性可卡犬因尿频、排尿困难和腹部疼痛而被转介。腹部的计算机断层扫描显示邻近膀胱的充满液体的结构。在手术探查时,发现一薄壁囊性结构,有血清出血液,从腹膜后间隙延伸到腹部。切除肿块并进行组织病理学检查,揭示腹膜后/肠系膜脂肪组织内纤维血管被膜衬里的囊性肿块。囊肿的内表面由一层平淡、扁平的梭形细胞排列。壁内血管分化良好,血管周围出血。在11个月后复发时,第二次切除肿块并放置胸膜移植 (诺福克动物产品)。初次就诊后15个月,囊性腔、胸腔和腹腔出现出血液体,病情进展,所有者选择安乐死。组织病理学和淋巴标记物阳性免疫组织化学淋巴管内皮透明质酸受体-1 (LYVE-1) 和prospero同源盒蛋白-1 (PROX-1) 证实了囊性结构的淋巴管起源。 结论: 根据我们的经验,只有结合临床表现、先进的影像学、组织病理学和LYVE-1和PROX-1免疫组织化学,才能明确诊断淋巴来源的腹膜后囊性畸形。这是第一个报告的血管畸形的狗,其中免疫组织化学进行了最后的诊断。如果患者腹膜后囊性结构中含有血清出血液,则应将淋巴管畸形列入鉴别诊断疾病。该病例报告的结果可以帮助诊断未来的病例,然而,需要进一步的治疗和管理研究,以提供关于这些患者的最佳治疗的额外信息。

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影响因子:3.60
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DOI:10.1245/s10434-019-07425-5
作者列表:["Ali YM","Sweeney J","Shen P","Votanopoulos KI","McQuellon R","Duckworth K","Perry KC","Russell G","Levine EA"]

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影响因子:3.60
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DOI:10.1245/s10434-019-07385-w
作者列表:["Bayat Z","Taylor EL","Bischof DA","McCart JA","Govindarajan A"]

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腹部肿瘤方向

腹部肿瘤主要包括腹壁肿瘤、胃癌、大肠癌、小肠肿瘤、肝癌、胆肿瘤、胰腺肿瘤、脾肿瘤、腹膜及腹膜后肿瘤、胃肠胰神经内分泌系统肿瘤等。

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