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The prevalence of hepatitis C virus in hemodialysis patients in Pakistan: A systematic review and meta-analysis.

巴基斯坦血液透析患者丙型肝炎病毒的患病率: 系统综述和荟萃分析。

  • 影响因子:3.02
  • DOI:10.1371/journal.pone.0232931
  • 作者列表:"Akhtar S","Nasir JA","Usman M","Sarwar A","Majeed R","Billah B
  • 发表时间:2020-05-14
Abstract

BACKGROUND:Hepatitis C virus (HCV) infection is one of the most common bloodborne viral infections reported in Pakistan. Frequent dialysis treatment of hemodialysis patients exposes them to a high risk of HCV infection. The main purpose of this paper is to quantify the prevalence of HCV in hemodialysis patients through a systematic review and meta-analysis. METHODS:We systematically searched PubMed, Medline, EMBASE, Pakistani Journals Online and Web of Science to identify studies published between 1 January 1995 and 30 October 2019, reporting on the prevalence of HCV infection in hemodialysis patients. Meta-analysis was performed using a random-effects model to obtain pooled estimates. A funnel plot was used in conjunction with Egger's regression test for asymmetry and to assess publication bias. Meta-regression and subgroup analyses were used to identify potential sources of heterogeneity among the included studies. This review was registered on PROSPERO (registration number CRD42019159345). RESULTS:Out of 248 potential studies, 19 studies involving 3446 hemodialysis patients were included in the meta-analysis. The pooled prevalence of HCV in hemodialysis patients in Pakistan was 32.33% (95% CI: 25.73-39.30; I2 = 94.3%, p < 0.01). The subgroup analysis showed that the prevalence of HCV among hemodialysis patients in Punjab was significantly higher (37.52%; 95% CI: 26.66-49.03; I2 = 94.5, p < 0.01) than 34.42% (95% CI: 14.95-57.05; I2 = 91.3%, p < 0.01) in Baluchistan, 27.11% (95% CI: 15.81-40.12; I2 = 94.5, p < 0.01) in Sindh and 22.61% (95% CI: 17.45-28.2; I2 = 78.6, p < 0.0117) in Khyber Pukhtoonkhuwa. CONCLUSIONS:In this study, we found a high prevalence (32.33%) of HCV infection in hemodialysis patients in Pakistan. Clinically, hemodialysis patients require more attention and resources than the general population. Preventive interventions are urgently needed to decrease the high risk of HCV infection in hemodialysis patients in Pakistan.

摘要

背景: 丙型肝炎病毒 (HCV) 感染是巴基斯坦报道的最常见的血源性病毒感染之一。血液透析患者的频繁透析治疗使他们暴露于HCV感染的高风险。本文的主要目的是通过系统回顾和荟萃分析来量化血液透析患者中HCV的患病率。 方法: 我们系统地检索了PubMed、Medline、EMBASE、巴基斯坦在线期刊和Web of Science,以确定1995年1月1日至20 19年10月30日期间发表的关于血液透析患者HCV感染流行率的研究。使用随机效应模型进行荟萃分析以获得汇总估计。漏斗图与Egger回归检验结合使用,用于不对称和评估发表偏倚。使用Meta回归和亚组分析确定纳入研究中异质性的潜在来源。本次审查在PROSPERO (注册号CRD42019159345) 上注册。 结果: 在248个潜在研究中,19个研究包括3446名血液透析患者被纳入荟萃分析。巴基斯坦血液透析患者中HCV的合并患病率为32.33% (95% CI: 25.73-39.30; I2 = 94.3%,p <0.01)。亚组分析显示,旁遮普省血液透析患者中HCV患病率 (37.52%; 95% CI: 26.66-49.03; I2 = 94.5,p <0.01) 显著高于俾路支省的34.42% (95% CI: 14.95-57.05; I2 = 91.3%,p <0.01),27.11% (95% CI: 15.81-40.12;I2 = 94.5,p <0.01) 在信德省和22.61% (95% CI: 17.45-28.2; I2 = 78.6,p <0.0117) 在Khyber Pukhtoonkhuwa。 结论: 在这项研究中,我们发现在巴基斯坦的血液透析患者中HCV感染的高患病率 (32.33%)。临床上,血液透析患者比普通人群需要更多的关注和资源。迫切需要预防性干预措施来降低巴基斯坦血液透析患者HCV感染的高风险。

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影响因子:1.44
发表时间:2020-01-01
DOI:10.1111/nep.13588
作者列表:["Yeh EL","Chen CH","Huang SC","Huang YC"]

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