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Relationship of chest CT score with clinical characteristics of 108 patients hospitalized with COVID-19 in Wuhan, China.

武汉市COVID-19 108例住院患者胸部CT评分与临床特征的关系 [j].

  • 影响因子:3.68
  • DOI:10.1186/s12931-020-01440-x
  • 作者列表:"Zhang J","Meng G","Li W","Shi B","Dong H","Su Z","Huang Q","Gao P
  • 发表时间:2020-07-14
Abstract

BACKGROUND:In December 2019, the outbreak of a disease subsequently termed COVID-19 occurred in Wuhan, China. The number of cases increased rapidly and spread to six continents. However, there is limited information on the chest computed tomography (CT) results of affected patients. Chest CT can assess the severity of COVID-19 and has sufficient sensitivity to assess changes in response to glucocorticoid therapy. OBJECTIVE:Analyze COVID-19 patients to determine the relationships of clinical characteristics, chest CT score, and levels of inflammatory mediators. METHODS:This retrospective, single-center case series of 108 consecutive hospitalized patients with confirmed COVID-19 at Tongji Hospital, Tongji Medical College of HUST (Wuhan, China) examined patients admitted from January 28 to February 20, 2020. Patient demographics, comorbidities, clinical findings, chest CT results, and CT scores of affected lung parenchyma were recorded. The relationships between chest CT score with levels of systemic inflammatory mediators were determined. RESULTS:All patients exhibited signs of significant systemic inflammation, including increased levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), procalcitonin, chest CT score, and a decreased lymphocyte (LY) count. Chest CT score had positive associations with white blood cell (WBC) count, CRP, ESR, procalcitonin, and abnormal coagulation function, and a negative association with LY count. Treatment with a glucocorticoid increased the LY count, reduced the CT score and CRP level, and improved coagulation function. CONCLUSIONS:COVID-19 infection is characterized by a systemic inflammatory response that affects the lungs, blood, digestive system, and circulatory systems. The chest CT score is a good indicator of the extent of systemic inflammation. Glucocorticoid treatment appears to reduce systemic inflammation in these patients.

摘要

背景: 2019年12月,在中国武汉爆发了一种后来称为COVID-19的疾病。病例数迅速增加,并蔓延至六大洲。然而,关于受影响患者的胸部计算机断层扫描 (CT) 结果的信息有限。胸部CT可以评估COVID-19的严重程度,并且具有足够的灵敏度来评估对糖皮质激素治疗的反应变化。 目的: 分析COVID-19例患者临床特征、胸部CT评分与炎症介质水平的关系。 方法: 回顾性、单中心病例系列研究了COVID-19在华中科技大学同济医学院附属同济医院 (中国武汉) 确诊的108例连续住院患者,检查了2020年1月28日至2月20日收治的患者。记录患者人口统计学、合并症、临床发现、胸部CT结果和受累肺实质的CT评分。测定胸部CT评分与全身炎症介质水平之间的关系。 结果: 所有患者均表现出明显的全身性炎症体征,包括C反应蛋白 (CRP) 、红细胞沉降率 (ESR) 、降钙素原、胸部CT评分和淋巴细胞 (LY) 计数水平升高。胸部CT评分与白细胞 (WBC) 计数、CRP、ESR、降钙素原和凝血功能异常呈正相关,与LY计数呈负相关。糖皮质激素治疗增加了LY计数,降低了CT评分和CRP水平,改善了凝血功能。 结论: COVID-19感染以影响肺、血液、消化系统和循环系统的全身性炎症反应为特征。胸部CT评分是反映全身炎症程度的良好指标。糖皮质激素治疗似乎减少了这些患者的全身性炎症。

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影响因子:0.85
发表时间:2020-01-02
来源期刊:Laboratory medicine
DOI:10.1093/labmed/lmz025
作者列表:["Tang J","Jiang Y","Ge Z","Wu H","Chen H","Dai J","Gu Y","Mao X","Lu J"]

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影响因子:3.23
发表时间:2020-02-01
DOI:10.5858/arpa.2019-0045-CP
作者列表:["Barkan GA","Tabatabai ZL","Kurtycz DFI","Padmanabhan V","Souers RJ","Nayar R","Sturgis CD"]

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临床化学检测方向

临床化学检测,用于诊断或治疗疾病的实验室检测,常用的检查物有:血液、尿液、组织和体液等。

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